Molecular genetics and genomics of heart failure.

Journal Article (Journal Article;Review)

Heart failure is a major disease burden worldwide, and its incidence continues to increase as premature deaths from other cardiovascular conditions decline. Although the overall molecular portrait of this multifactorial disease remains incomplete, molecular and genetic studies have implicated, in recent decades, various pathways and genes that participate in the pathophysiology of heart failure. Here, we highlight the current understanding of the molecular and genetic basis of heart failure and show how recently developed genomic tools are providing a new perspective on this complex disease.

Full Text

Duke Authors

Cited Authors

  • Liew, C-C; Dzau, VJ

Published Date

  • November 2004

Published In

Volume / Issue

  • 5 / 11

Start / End Page

  • 811 - 825

PubMed ID

  • 15520791

International Standard Serial Number (ISSN)

  • 1471-0056

Digital Object Identifier (DOI)

  • 10.1038/nrg1470


  • eng

Conference Location

  • England