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MLL duplication in a pediatric patient with B-cell lymphoblastic lymphoma.

Publication ,  Journal Article
Mater, DV; Goodman, BK; Wang, E; Gaca, AM; Wechsler, DS
Published in: J Pediatr Hematol Oncol
April 2012

Lymphoblastic lymphoma is the second most common type of non-Hodgkin lymphoma seen in children. Approximately, 90% of lymphoblastic lymphomas arise from T cells, with the remaining 10% being B-cell-lineage derived. Although T-cell lymphoblastic lymphoma most frequently occurs in the anterior mediastinum (thymus), B-cell lymphoblastic lymphoma (B-LBL) predominates in extranodal sites such as skin and bone. Here, we describe a pediatric B-LBL patient who presented with extensive abdominal involvement and whose lymphoma cells displayed segmental duplication of the mixed lineage leukemia (MLL) gene. MLL duplication/amplification has been described primarily in acute myeloid leukemia and myelodysplastic syndrome with no published reports of discrete MLL duplication/amplification events in B-LBL. The MLL gene duplication noted in this case may represent a novel mechanism for tumorigenesis in B-LBL.

Duke Scholars

Published In

J Pediatr Hematol Oncol

DOI

EISSN

1536-3678

Publication Date

April 2012

Volume

34

Issue

3

Start / End Page

e120 / e123

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
  • Oncology & Carcinogenesis
  • Myeloid-Lymphoid Leukemia Protein
  • Male
  • Humans
  • Histone-Lysine N-Methyltransferase
  • Gene Duplication
  • Flow Cytometry
  • Cytogenetic Analysis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mater, D. V., Goodman, B. K., Wang, E., Gaca, A. M., & Wechsler, D. S. (2012). MLL duplication in a pediatric patient with B-cell lymphoblastic lymphoma. J Pediatr Hematol Oncol, 34(3), e120–e123. https://doi.org/10.1097/MPH.0b013e3182273b57
Mater, David Van, Barbara K. Goodman, Endi Wang, Ana M. Gaca, and Daniel S. Wechsler. “MLL duplication in a pediatric patient with B-cell lymphoblastic lymphoma.J Pediatr Hematol Oncol 34, no. 3 (April 2012): e120–23. https://doi.org/10.1097/MPH.0b013e3182273b57.
Mater DV, Goodman BK, Wang E, Gaca AM, Wechsler DS. MLL duplication in a pediatric patient with B-cell lymphoblastic lymphoma. J Pediatr Hematol Oncol. 2012 Apr;34(3):e120–3.
Mater, David Van, et al. “MLL duplication in a pediatric patient with B-cell lymphoblastic lymphoma.J Pediatr Hematol Oncol, vol. 34, no. 3, Apr. 2012, pp. e120–23. Pubmed, doi:10.1097/MPH.0b013e3182273b57.
Mater DV, Goodman BK, Wang E, Gaca AM, Wechsler DS. MLL duplication in a pediatric patient with B-cell lymphoblastic lymphoma. J Pediatr Hematol Oncol. 2012 Apr;34(3):e120–e123.

Published In

J Pediatr Hematol Oncol

DOI

EISSN

1536-3678

Publication Date

April 2012

Volume

34

Issue

3

Start / End Page

e120 / e123

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
  • Oncology & Carcinogenesis
  • Myeloid-Lymphoid Leukemia Protein
  • Male
  • Humans
  • Histone-Lysine N-Methyltransferase
  • Gene Duplication
  • Flow Cytometry
  • Cytogenetic Analysis