MLL duplication in a pediatric patient with B-cell lymphoblastic lymphoma.


Journal Article

Lymphoblastic lymphoma is the second most common type of non-Hodgkin lymphoma seen in children. Approximately, 90% of lymphoblastic lymphomas arise from T cells, with the remaining 10% being B-cell-lineage derived. Although T-cell lymphoblastic lymphoma most frequently occurs in the anterior mediastinum (thymus), B-cell lymphoblastic lymphoma (B-LBL) predominates in extranodal sites such as skin and bone. Here, we describe a pediatric B-LBL patient who presented with extensive abdominal involvement and whose lymphoma cells displayed segmental duplication of the mixed lineage leukemia (MLL) gene. MLL duplication/amplification has been described primarily in acute myeloid leukemia and myelodysplastic syndrome with no published reports of discrete MLL duplication/amplification events in B-LBL. The MLL gene duplication noted in this case may represent a novel mechanism for tumorigenesis in B-LBL.

Full Text

Duke Authors

Cited Authors

  • Mater, DV; Goodman, BK; Wang, E; Gaca, AM; Wechsler, DS

Published Date

  • April 2012

Published In

Volume / Issue

  • 34 / 3

Start / End Page

  • e120 - e123

PubMed ID

  • 22052166

Pubmed Central ID

  • 22052166

Electronic International Standard Serial Number (EISSN)

  • 1536-3678

Digital Object Identifier (DOI)

  • 10.1097/MPH.0b013e3182273b57


  • eng

Conference Location

  • United States