Presence of diverse human immunodeficiency virus type 1 viral variants in Cameroon.

Published

Journal Article

Phylogenetic analysis of the gp41 region of 123 HIV-1-seropositive specimens from Cameroon showed that 89 were subtype A (71% of these sequences were IbNg-like), 12 (10%) were subtype D, 11 (9%) were subtype G, 5 (4%; closely related to subtype F2) were subtype F, 1 was subtype H, 2 (1.6%) remained unclassifiable, while 3 were group O. Further analysis of the two unclassifiable specimens in gag(p24), pol(prot), and env (C2V3 or gp41) showed that one (98CM19) was a complex mosaic between subtype A in p24 and subtype J prot, and unclassifiable in env (C2V3 or gp41). The second, 98CM63, clustered distinctly from all known subtypes in p24, prot, C2V3, or gp41. 98CM63 clustered with a specimen from Cyprus and these two geographically and epidemiologically unlinked specimens, with their distinct clustering pattern, may represent a new subcluster of subtype A. In conclusion, these findings confirm the high HIV-1 genetic variability and further suggest the continuous appearance of new viral strains in this population.

Full Text

Duke Authors

Cited Authors

  • Fonjungo, PN; Mpoudi, EN; Torimiro, JN; Alemnji, GA; Eno, LT; Nkengasong, JN; Gao, F; Rayfield, M; Folks, TM; Pieniazek, D; Lal, RB

Published Date

  • September 1, 2000

Published In

Volume / Issue

  • 16 / 13

Start / End Page

  • 1319 - 1324

PubMed ID

  • 10957729

Pubmed Central ID

  • 10957729

International Standard Serial Number (ISSN)

  • 0889-2229

Digital Object Identifier (DOI)

  • 10.1089/08892220050117087

Language

  • eng

Conference Location

  • United States