Interleukin-28B gene polymorphisms do not influence the susceptibility to HIV-infection or CD4 cell decline.

Journal Article (Journal Article)

The critical role of interleukin-28B (IL28B)/interferon-λ3 (IFN-λ3) polymorphisms on the susceptibility to hepatitis C virus infection and the response to peginterferon-ribavirin therapy has encouraged exploration of similar effects on other viruses. Given that IFN-λ mediates anti-HIV-1 activity, the protective role of IL28B polymorphisms was examined in 29 seronegative individuals at risk for HIV-infection and in 68 HIV-positive carriers with and without rapid progression of immunodeficiency. No protective role of IL28B polymorphism was found examining both HIV-disease progression and HIV-protection.

Full Text

Duke Authors

Cited Authors

  • Rallon, NI; Restrepo, C; Naggie, S; Lopez, M; Del Romero, J; Goldstein, D; McHutchison, J; Soriano, V; Benito, JM

Published Date

  • January 14, 2011

Published In

Volume / Issue

  • 25 / 2

Start / End Page

  • 269 - 271

PubMed ID

  • 21099665

Electronic International Standard Serial Number (EISSN)

  • 1473-5571

Digital Object Identifier (DOI)

  • 10.1097/QAD.0b013e328341b84e


  • eng

Conference Location

  • England