Skip to main content

Interleukin-28B gene polymorphisms do not influence the susceptibility to HIV-infection or CD4 cell decline.

Publication ,  Journal Article
Rallon, NI; Restrepo, C; Naggie, S; Lopez, M; Del Romero, J; Goldstein, D; McHutchison, J; Soriano, V; Benito, JM
Published in: AIDS
January 14, 2011

The critical role of interleukin-28B (IL28B)/interferon-λ3 (IFN-λ3) polymorphisms on the susceptibility to hepatitis C virus infection and the response to peginterferon-ribavirin therapy has encouraged exploration of similar effects on other viruses. Given that IFN-λ mediates anti-HIV-1 activity, the protective role of IL28B polymorphisms was examined in 29 seronegative individuals at risk for HIV-infection and in 68 HIV-positive carriers with and without rapid progression of immunodeficiency. No protective role of IL28B polymorphism was found examining both HIV-disease progression and HIV-protection.

Duke Scholars

Published In

AIDS

DOI

EISSN

1473-5571

Publication Date

January 14, 2011

Volume

25

Issue

2

Start / End Page

269 / 271

Location

England

Related Subject Headings

  • Virology
  • Viral Load
  • Risk Assessment
  • RNA, Viral
  • Polymorphism, Single Nucleotide
  • Male
  • Interleukins
  • Interferons
  • Humans
  • HIV-1
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rallon, N. I., Restrepo, C., Naggie, S., Lopez, M., Del Romero, J., Goldstein, D., … Benito, J. M. (2011). Interleukin-28B gene polymorphisms do not influence the susceptibility to HIV-infection or CD4 cell decline. AIDS, 25(2), 269–271. https://doi.org/10.1097/QAD.0b013e328341b84e
Rallon, Norma I., Clara Restrepo, Susanna Naggie, Mariola Lopez, Jorge Del Romero, David Goldstein, John McHutchison, Vincent Soriano, and Jose M. Benito. “Interleukin-28B gene polymorphisms do not influence the susceptibility to HIV-infection or CD4 cell decline.AIDS 25, no. 2 (January 14, 2011): 269–71. https://doi.org/10.1097/QAD.0b013e328341b84e.
Rallon NI, Restrepo C, Naggie S, Lopez M, Del Romero J, Goldstein D, et al. Interleukin-28B gene polymorphisms do not influence the susceptibility to HIV-infection or CD4 cell decline. AIDS. 2011 Jan 14;25(2):269–71.
Rallon, Norma I., et al. “Interleukin-28B gene polymorphisms do not influence the susceptibility to HIV-infection or CD4 cell decline.AIDS, vol. 25, no. 2, Jan. 2011, pp. 269–71. Pubmed, doi:10.1097/QAD.0b013e328341b84e.
Rallon NI, Restrepo C, Naggie S, Lopez M, Del Romero J, Goldstein D, McHutchison J, Soriano V, Benito JM. Interleukin-28B gene polymorphisms do not influence the susceptibility to HIV-infection or CD4 cell decline. AIDS. 2011 Jan 14;25(2):269–271.

Published In

AIDS

DOI

EISSN

1473-5571

Publication Date

January 14, 2011

Volume

25

Issue

2

Start / End Page

269 / 271

Location

England

Related Subject Headings

  • Virology
  • Viral Load
  • Risk Assessment
  • RNA, Viral
  • Polymorphism, Single Nucleotide
  • Male
  • Interleukins
  • Interferons
  • Humans
  • HIV-1