Skip to main content
Journal cover image

[3H]-flunitrazepam-labeled benzodiazepine binding sites in the hippocampal formation in autism: a multiple concentration autoradiographic study.

Publication ,  Journal Article
Guptill, JT; Booker, AB; Gibbs, TT; Kemper, TL; Bauman, ML; Blatt, GJ
Published in: J Autism Dev Disord
May 2007

Increasing evidence indicates that the GABAergic system in cerebellar and limbic structures is affected in autism. We extended our previous study that found reduced [(3)H]flunitrazepam-labeled benzodiazepine sites in the autistic hippocampus to determine whether this reduction was due to a decrease in binding site number (B (max)) or altered affinity (K (d)) to bind to the ligand. Quantitation of hippocampal lamina demonstrated a 20% reduction in B (max) indicating a trend toward a decreased number of benzodiazepine binding sites in the autistic group but normal K (d) values. A reduction in the number of hippocampal benzodiazepine binding sites suggests alterations in the modulation of GABA(A) receptors in the presence of GABA in the autistic brain, possibly resulting in altered inhibitory functioning of hippocampal circuitry.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Autism Dev Disord

DOI

ISSN

0162-3257

Publication Date

May 2007

Volume

37

Issue

5

Start / End Page

911 / 920

Location

United States

Related Subject Headings

  • Receptors, GABA
  • Nissl Bodies
  • Nerve Net
  • Male
  • Humans
  • Hippocampus
  • GABA Modulators
  • Flunitrazepam
  • Developmental & Child Psychology
  • Cerebellum
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Guptill, J. T., Booker, A. B., Gibbs, T. T., Kemper, T. L., Bauman, M. L., & Blatt, G. J. (2007). [3H]-flunitrazepam-labeled benzodiazepine binding sites in the hippocampal formation in autism: a multiple concentration autoradiographic study. J Autism Dev Disord, 37(5), 911–920. https://doi.org/10.1007/s10803-006-0226-7
Guptill, Jeffrey T., Anne B. Booker, Terrell T. Gibbs, Thomas L. Kemper, Margaret L. Bauman, and Gene J. Blatt. “[3H]-flunitrazepam-labeled benzodiazepine binding sites in the hippocampal formation in autism: a multiple concentration autoradiographic study.J Autism Dev Disord 37, no. 5 (May 2007): 911–20. https://doi.org/10.1007/s10803-006-0226-7.
Guptill JT, Booker AB, Gibbs TT, Kemper TL, Bauman ML, Blatt GJ. [3H]-flunitrazepam-labeled benzodiazepine binding sites in the hippocampal formation in autism: a multiple concentration autoradiographic study. J Autism Dev Disord. 2007 May;37(5):911–20.
Guptill, Jeffrey T., et al. “[3H]-flunitrazepam-labeled benzodiazepine binding sites in the hippocampal formation in autism: a multiple concentration autoradiographic study.J Autism Dev Disord, vol. 37, no. 5, May 2007, pp. 911–20. Pubmed, doi:10.1007/s10803-006-0226-7.
Guptill JT, Booker AB, Gibbs TT, Kemper TL, Bauman ML, Blatt GJ. [3H]-flunitrazepam-labeled benzodiazepine binding sites in the hippocampal formation in autism: a multiple concentration autoradiographic study. J Autism Dev Disord. 2007 May;37(5):911–920.
Journal cover image

Published In

J Autism Dev Disord

DOI

ISSN

0162-3257

Publication Date

May 2007

Volume

37

Issue

5

Start / End Page

911 / 920

Location

United States

Related Subject Headings

  • Receptors, GABA
  • Nissl Bodies
  • Nerve Net
  • Male
  • Humans
  • Hippocampus
  • GABA Modulators
  • Flunitrazepam
  • Developmental & Child Psychology
  • Cerebellum