Epithelial stem/progenitor cells in lung postnatal growth, maintenance, and repair.

Journal Article (Journal Article;Review)

The adult lung consists of a trachea leading into a system of branched airways ending in millions of alveolar sacs. It contains many different epithelial cell types arranged in precise patterns along the proximodistal axis. Each region of the lung has the capacity to repair through the proliferation of different epithelial cell types. However, the precise identity of the cells mediating repair is not fully resolved. To address this problem, we are using genetic lineage-labeling techniques in the mouse. The tools we have made will also be useful for understanding how progenitor cell behavior is regulated under normal and pathological conditions.

Full Text

Duke Authors

Cited Authors

  • Rawlins, EL; Okubo, T; Que, J; Xue, Y; Clark, C; Luo, X; Hogan, BLM

Published Date

  • 2008

Published In

Volume / Issue

  • 73 /

Start / End Page

  • 291 - 295

PubMed ID

  • 19028985

Electronic International Standard Serial Number (EISSN)

  • 1943-4456

Digital Object Identifier (DOI)

  • 10.1101/sqb.2008.73.037


  • eng

Conference Location

  • United States