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The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate.

Publication ,  Journal Article
Wilm, B; James, RG; Schultheiss, TM; Hogan, BLM
Published in: Dev Biol
July 1, 2004

During vertebrate embryogenesis, the newly formed mesoderm is allocated to the paraxial, intermediate, and lateral domains, each giving rise to different cell and tissue types. Here, we provide evidence that the forkhead genes, Foxc1 and Foxc2, play a role in the specification of mesoderm to paraxial versus intermediate fates. Mouse embryos lacking both Foxc1 and Foxc2 show expansion of intermediate mesoderm markers into the paraxial domain, lateralization of somite patterning, and ectopic and disorganized mesonephric tubules. In gain of function studies in the chick embryo, Foxc1 and Foxc2 negatively regulate intermediate mesoderm formation. By contrast, their misexpression in the prospective intermediate mesoderm appears to drive cells to acquire paraxial fate, as revealed by expression of the somite markers Pax7 and Paraxis. Taken together, the data indicate that Foxc1 and Foxc2 regulate the establishment of paraxial versus intermediate mesoderm cell fates in the vertebrate embryo.

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Published In

Dev Biol

DOI

ISSN

0012-1606

Publication Date

July 1, 2004

Volume

271

Issue

1

Start / End Page

176 / 189

Location

United States

Related Subject Headings

  • Transcription Factors
  • Somites
  • PAX7 Transcription Factor
  • Mice
  • Mesoderm
  • In Situ Hybridization
  • Immunohistochemistry
  • Homeodomain Proteins
  • Gene Expression Regulation, Developmental
  • Forkhead Transcription Factors
 

Citation

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Wilm, B., James, R. G., Schultheiss, T. M., & Hogan, B. L. M. (2004). The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate. Dev Biol, 271(1), 176–189. https://doi.org/10.1016/j.ydbio.2004.03.034
Wilm, Bettina, Richard G. James, Thomas M. Schultheiss, and Brigid L. M. Hogan. “The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate.Dev Biol 271, no. 1 (July 1, 2004): 176–89. https://doi.org/10.1016/j.ydbio.2004.03.034.
Wilm B, James RG, Schultheiss TM, Hogan BLM. The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate. Dev Biol. 2004 Jul 1;271(1):176–89.
Wilm, Bettina, et al. “The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate.Dev Biol, vol. 271, no. 1, July 2004, pp. 176–89. Pubmed, doi:10.1016/j.ydbio.2004.03.034.
Wilm B, James RG, Schultheiss TM, Hogan BLM. The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate. Dev Biol. 2004 Jul 1;271(1):176–189.
Journal cover image

Published In

Dev Biol

DOI

ISSN

0012-1606

Publication Date

July 1, 2004

Volume

271

Issue

1

Start / End Page

176 / 189

Location

United States

Related Subject Headings

  • Transcription Factors
  • Somites
  • PAX7 Transcription Factor
  • Mice
  • Mesoderm
  • In Situ Hybridization
  • Immunohistochemistry
  • Homeodomain Proteins
  • Gene Expression Regulation, Developmental
  • Forkhead Transcription Factors