The TGF-β-related signalling system in mouse development

Journal Article (Journal Article)

Secreted polypeptide signalling molecules of the TGF- superfamily play critical roles during mouse development. There are 20 known members of this diverse family in the mouse, including the TGF-s, inhibin/activins, BMPs, GDFs, and nodal. Mutations in genes for some of these ligands have been identified or created by targeted mutagenesis. A complex network of binding proteins, proteases, and receptors is involved in the processing, presentation and biological activity of TGF-β-related ligands. It is likely that variations in these modifying factors will explain how different genetic backgrounds can influence the severity and penetrance of mutant phenotypes. © 1995 Academic Press Ltd.

Full Text

Duke Authors

Cited Authors

  • Hogan, BLM

Published Date

  • January 1, 1995

Published In

Volume / Issue

  • 6 / 4

Start / End Page

  • 257 - 265

International Standard Serial Number (ISSN)

  • 1044-5781

Digital Object Identifier (DOI)

  • 10.1016/S1044-5781(06)80051-4

Citation Source

  • Scopus