Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses.

Published

Journal Article

Cryptochromes are photoactive pigments in the eye that have been proposed to function as circadian photopigments. Mice lacking the cryptochrome 2 blue-light photoreceptor gene (mCry2) were tested for circadian clock-related functions. The mutant mice had a lower sensitivity to acute light induction of mPer1 in the suprachiasmatic nucleus (SCN) but exhibited normal circadian oscillations of mPer1 and mCry1 messenger RNA in the SCN. Behaviorally, the mutants had an intrinsic circadian period about 1 hour longer than normal and exhibited high-amplitude phase shifts in response to light pulses administered at circadian time 17. These data are consistent with the hypothesis that CRY2 protein modulates circadian responses in mice and suggest that cryptochromes have a role in circadian photoreception in mammals.

Full Text

Duke Authors

Cited Authors

  • Thresher, RJ; Vitaterna, MH; Miyamoto, Y; Kazantsev, A; Hsu, DS; Petit, C; Selby, CP; Dawut, L; Smithies, O; Takahashi, JS; Sancar, A

Published Date

  • November 1998

Published In

Volume / Issue

  • 282 / 5393

Start / End Page

  • 1490 - 1494

PubMed ID

  • 9822380

Pubmed Central ID

  • 9822380

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.282.5393.1490

Language

  • eng