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Sample size for a two-group comparison of repeated binary measurements using GEE.

Publication ,  Journal Article
Jung, S-H; Ahn, CW
Published in: Stat Med
September 15, 2005

Controlled clinical trials often randomize subjects to two treatment groups and repeatedly evaluate them at baseline and intervals across a treatment period of fixed duration. A popular primary objective in these trials is to compare the change rates in the repeated measurements between treatment groups. Repeated measurements usually involve missing data and a serial correlation within each subject. The generalized estimating equation (GEE) method has been widely used to fit the time trend in repeated measurements because of its robustness to random missing and mispecification of the true correlation structure. In this paper, we propose a closed form sample size formula for comparing the change rates of binary repeated measurements using GEE for a two-group comparison. The sample size formula is derived incorporating missing patterns, such as independent missing and monotone missing, and correlation structures, such as AR(1) model. We also propose an algorithm to generate correlated binary data with arbitrary marginal means and a Markov dependency and use it in simulation studies.

Duke Scholars

Published In

Stat Med

DOI

ISSN

0277-6715

Publication Date

September 15, 2005

Volume

24

Issue

17

Start / End Page

2583 / 2596

Location

England

Related Subject Headings

  • Statistics & Probability
  • Scleroderma, Systemic
  • Sample Size
  • Randomized Controlled Trials as Topic
  • Pulmonary Fibrosis
  • Models, Statistical
  • Longitudinal Studies
  • Humans
  • Computer Simulation
  • Algorithms
 

Citation

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Jung, S.-H., & Ahn, C. W. (2005). Sample size for a two-group comparison of repeated binary measurements using GEE. Stat Med, 24(17), 2583–2596. https://doi.org/10.1002/sim.2136
Jung, Sin-Ho, and Chul W. Ahn. “Sample size for a two-group comparison of repeated binary measurements using GEE.Stat Med 24, no. 17 (September 15, 2005): 2583–96. https://doi.org/10.1002/sim.2136.
Jung S-H, Ahn CW. Sample size for a two-group comparison of repeated binary measurements using GEE. Stat Med. 2005 Sep 15;24(17):2583–96.
Jung, Sin-Ho, and Chul W. Ahn. “Sample size for a two-group comparison of repeated binary measurements using GEE.Stat Med, vol. 24, no. 17, Sept. 2005, pp. 2583–96. Pubmed, doi:10.1002/sim.2136.
Jung S-H, Ahn CW. Sample size for a two-group comparison of repeated binary measurements using GEE. Stat Med. 2005 Sep 15;24(17):2583–2596.
Journal cover image

Published In

Stat Med

DOI

ISSN

0277-6715

Publication Date

September 15, 2005

Volume

24

Issue

17

Start / End Page

2583 / 2596

Location

England

Related Subject Headings

  • Statistics & Probability
  • Scleroderma, Systemic
  • Sample Size
  • Randomized Controlled Trials as Topic
  • Pulmonary Fibrosis
  • Models, Statistical
  • Longitudinal Studies
  • Humans
  • Computer Simulation
  • Algorithms