Wild-type p53: tumors can't stand it.

Journal Article (Journal Article;Review)

Most malignant tumors disrupt the p53 signaling pathway in order to grow and survive. Although many genes in addition to p53 are mutated in tumors, recent studies by Ventura et al. (2007) and Xue et al. (2007) suggest that restoring p53 function alone is sufficient to cause regression of several different tumor types in mice and thus might represent a potent therapeutic strategy to treat certain human cancers. Martins et al. (2006) also demonstrate that restoration of p53 activity results in tumor regression but add the sobering caveat that tumors may be able to quickly generate resistance by finding other ways to disrupt the p53 pathway.

Full Text

Duke Authors

Cited Authors

  • Kastan, MB

Published Date

  • March 9, 2007

Published In

Volume / Issue

  • 128 / 5

Start / End Page

  • 837 - 840

PubMed ID

  • 17350571

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2007.02.022


  • eng

Conference Location

  • United States