Molecular biology of nuclear autoantigens.

Journal Article (Review)

This article provides a historical overview of the application of molecular and immunologic techniques to the analysis of autoantigenic structure and function, as well as to autoantibody recognition of protein and nucleic acid autoantigens. Examples presented here illustrate the role of autoantibodies as tools in the elucidation of the autoimmune components of cellular ribonucleoproteins. In turn, the subsequent molecular dissection of autoantigenic ribonucleoproteins has advanced understanding of autoantibody specificities. The nature of autoantibodies reactive with various proteins and nucleic acids will be the subject of the following articles in this issue. Taken together, these studies of antibody-antigen interactions that arise during the autoimmune response have revealed novel mechanisms of molecular recognition within the RNP autoantigens. These findings are of general importance for understanding basic cellular processes and have contributed to our knowledge of the underlying mechanisms of immunoregulatory abnormalities that arise in autoimmune diseases.

Full Text

Duke Authors

Cited Authors

  • Saitta, MR; Keene, JD

Published Date

  • May 1992

Published In

Volume / Issue

  • 18 / 2

Start / End Page

  • 283 - 310

PubMed ID

  • 1626070

International Standard Serial Number (ISSN)

  • 0889-857X

Language

  • eng

Conference Location

  • United States