Jack Donald Keene | Scholars@Duke

Jack Donald Keene
James B. Duke Professor of Molecular Genetics and Microbiology

The Keene Laboratory has a long-term interest in the structure and function of viral and mammalian genomes. Having determined the first genomic sequences for rabies, Ebola, Marburg and vesicular stomatitis virus, and discerned the origins of defective interfering viruses, interests shifted to the cloning of six human genes involved in autoimmune reactivity. This resulted in the identification of numerous autoimmune RRM-type RNA-binding proteins the discovery of the RRM, and the RNA targets to which they bind. The current interests of the lab surround the functions of the human RRM-ELAV/Hu proteins that are bound to a subset of cellular mRNAs involved in growth regulation neuronal plasticiyt and cancer. The laboratory demonstrated that ELAV/Hu proteins bind and regulate the expression of early response gene transcripts such as those encoding the protooncogene and cytokine proteins.

In addition, it was shown that while stabilizing these mRNAs and/or activating their translation, the ELAV/Hu proteins participate in cellular , differentiation and carcinogenesis. More recently, the laboratory has examined dozens of RNA-binding proteins in order to identify large numbers of structurally
and/or functionally related mRNAs that cluster in vivo based upon their binding to these proteins. This has been termed ribonomics because it involves parallel analysis of mRNA subsets en masse based upon their presence in messenger ribonucleoprotein complexes. This new approach to functional genomics is being applied to virus-infected cells, tumors and cells treated with various agents. Ribonomics has led to the identification of mRNA clusters that are posttranscriptionally regulated, and represent the organizational state of genetic information between the genome and the proteome. Dr. Keen has propsed the existence of post-transcriptional operons based upon the association of structurally and functionally-linked mRNAs in vivo.

Current Appointments & Affiliations

James B. Duke Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 1997
Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 1989
Associate Professor in Medicine, Medicine, Rheumatology and Immunology, Medicine 2006
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1979

Contact Information

207 Research Drive, 414 Jones Box 3020, Durham, NC 27717
Duke Box 3020, Durham, NC 27710
keene001@mc.duke.edu (919) 684-5138

Background
Education, Training, & Certifications
- Ph.D., University of Washington 1974
Duke Appointment History
- Associate Research Professor in Medicine, Medicine, Rheumatology and Immunology, Medicine 1999 - 2006
- Director, Center for RNA Biology, Molecular Genetics and Microbiology, Basic Science Departments 2002 - 2006
- Director of Basic Science Research, Comprehensive Cancer Center, Duke Cancer Institute, Institutes and Centers 1995 - 2003
- Chair, Department of Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 1994 - 2002
- Associate Research Professor in Medicine, Medicine, Clinical Science Departments 1994 - 1999
Recognition
Awards & Honors
Research
Selected Grants
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
- Transfusion Medicine and Hematology awarded by National Institutes of Health 1975 - 2021
- Interdisciplinary Research Training Program in AIDS awarded by National Institutes of Health 2010 - 2020
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Viral Oncology Training Grant awarded by National Institutes of Health 1980 - 2019
- Post-transcriptional RNA regulation in mammalian neural stem cells awarded by National Institutes of Health 2017 - 2019
- Mechanisms of neural progenitor division in the developing brain awarded by National Institutes of Health 2013 - 2018
- Targeting Translation Control in Malignant Glioma awarded by National Institutes of Health 2007 - 2018
- Post-transcriptional coordination by HuR and microRNAs during tumorigenesis awarded by National Institutes of Health 2014 - 2017
- RNA Dynamics of Transient Macromolecular Complexes in Cancer Cells awarded by National Institutes of Health 2011 - 2017
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- Clinical Oncology Research Career Development Program awarded by National Institutes of Health 2009 - 2015
- Regulation of Germ Cell Pluripotency Through The RNA-Binding Protein, DND1 awarded by National Institutes of Health 2010 - 2014
- RNA Operons In Coordinated Gene Expression and Horizontal Transfer awarded by National Science Foundation 2009 - 2012
- Mucin Gene Regulation by Elastase and Oxidants awarded by National Institutes of Health 2005 - 2010
- Development And Persistence Of Immunity In SCID Chimeras awarded by National Institutes of Health 1998 - 2010
- Posttranscriptional regulation of the Wnt pathway by HuR and microRNAs awarded by National Institutes of Health 2007 - 2009
- Endothelial Cell Molecular Alterations in Cancer awarded by National Institutes of Health 2002 - 2008
- Posttranscriptional Gene Regulation in T Cell Activation awarded by National Institutes of Health 2000 - 2007
- Stem Cell Mechanism in the Murine Germline awarded by National Institutes of Health 2002 - 2006
- Function of Mammalian ELAV RNA-Binding Proteins awarded by National Institutes of Health 1999 - 2006
- Regulation of Mucin Gene Expression by Elastase awarded by National Institutes of Health 2000 - 2005
- Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
- Comprehensive Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
- Comprehensive Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
- Determinants Of Specificity In Protein-Rna Interactions awarded by National Institutes of Health 1993 - 1998
- Peptide Immunogens For Mucosal & Systemic Hiv Vaccines Nat awarded by National Institutes of Health 1993 - 1997
- Molecular Biology Of The Ro-Rnp Autoantigen awarded by National Institutes of Health 1993 - 1994
- Replicative Mechanisms Of The Negative Strand Viruses awarded by National Institutes of Health 1992 - 1993
- Replicative Mechanisms Of The Negative Strand Viruses awarded by National Institutes of Health 1991 - 1993
- Replicative Mechanisms Of The Negative Strant Viruses awarded by National Institutes of Health 1990 - 1993
- Replicative Mechnaisms Of The Negative Strand Viruses awarded by National Institutes of Health 1986 - 1988
Publications & Artistic Works
Selected Publications
- Book Sections
  - Keene, JD. "Preface." January 1, 2013. Full Text
- Journal Articles
  - Bisogno, LS, and Keene, JD. "RNA regulons in cancer and inflammation." Current opinion in genetics & development 48 (February 2018): 97-103. (Review) Full Text
  - Bisogno, LS, and Keene, JD. "Analysis of post-transcriptional regulation during cancer progression using a donor-derived isogenic model of tumorigenesis." Methods (San Diego, Calif.) 126 (August 2017): 193-200. Full Text
  - Nicholson, CO, Friedersdorf, MB, Bisogno, LS, and Keene, JD. "DO-RIP-seq to quantify RNA binding sites transcriptome-wide." Methods (San Diego, Calif.) 118-119 (April 2017): 16-23. Full Text
  - Nicholson, CO, Friedersdorf, M, and Keene, JD. "Quantifying RNA binding sites transcriptome-wide using DO-RIP-seq." RNA (New York, N.Y.) 23, no. 1 (January 2017): 32-46. Full Text
  - Smola, MJ, Christy, TW, Inoue, K, Nicholson, CO, Friedersdorf, M, Keene, JD, Lee, DM, Calabrese, JM, and Weeks, KM. "SHAPE reveals transcript-wide interactions, complex structural domains, and protein interactions across the Xist lncRNA in living cells." Proceedings of the National Academy of Sciences of the United States of America 113, no. 37 (September 2016): 10322-10327. Full Text
  - Blackinton, JG, and Keene, JD. "Functional coordination and HuR-mediated regulation of mRNA stability during T cell activation." Nucleic acids research 44, no. 1 (January 2016): 426-436. Full Text Open Access Copy
  - Moon, SL, Blackinton, JG, Anderson, JR, Dozier, MK, Dodd, BJT, Keene, JD, Wilusz, CJ, Bradrick, SS, and Wilusz, J. "XRN1 stalling in the 5' UTR of Hepatitis C virus and Bovine Viral Diarrhea virus is associated with dysregulated host mRNA stability." PLoS pathogens 11, no. 3 (March 6, 2015): e1004708-. Full Text
  - Jiang, H, Xu, L, Wang, Z, Keene, J, and Gu, Z. "Coordinating expression of RNA binding proteins with their mRNA targets." Scientific reports 4 (November 24, 2014): 7175-. Full Text
  - Blackinton, JG, and Keene, JD. "Post-transcriptional RNA regulons affecting cell cycle and proliferation." Seminars in cell & developmental biology 34 (October 2014): 44-54. (Review) Full Text
  - Blackinton, JG, and Keene, JD. "Post-transcriptional RNA regulons affecting cell cycle and proliferation." Seminars in Cell and Developmental Biology 34 (October 1, 2014): 44-54. (Review) Full Text
  - Payne, TL, Blackinton, J, Frisbee, A, Pickeral, J, Sawant, S, Vandergrift, NA, Freel, SA, Ferrari, G, Keene, JD, and Tomaras, GD. "Transcriptional and posttranscriptional regulation of cytokine gene expression in HIV-1 antigen-specific CD8+ T cells that mediate virus inhibition." Journal of virology 88, no. 17 (September 2014): 9514-9528. Full Text
  - Keene, JD. "The globalization of messenger RNA regulation." National science review 1, no. 2 (June 2014): 184-186. Full Text
  - Friedersdorf, MB, and Keene, JD. "Advancing the functional utility of PAR-CLIP by quantifying background binding to mRNAs and lncRNAs. (Published online)" Genome Biol 15, no. 1 (January 7, 2014): R2-. Full Text Link to Item
  - Simone, LE, and Keene, JD. "Mechanisms coordinating ELAV/Hu mRNA regulons." Curr Opin Genet Dev 23, no. 1 (February 2013): 35-43. (Review) Full Text Link to Item
  - Keene, JD. "Preface." Advances in Experimental Medicine and Biology 768 (2013): v-vi. Full Text
  - Simone, LE, and Keene, JD. "Mechanisms coordinating ELAV/Hu mRNA regulons." Current Opinion in Genetics and Development 23, no. 1 (2013): 35-43. Full Text
  - Mansfield, KD, and Keene, JD. "Neuron-specific ELAV/Hu proteins suppress HuR mRNA during neuronal differentiation by alternative polyadenylation." Nucleic Acids Res 40, no. 6 (March 2012): 2734-2746. Full Text Link to Item
  - Corcoran, DL, Georgiev, S, Mukherjee, N, Gottwein, E, Skalsky, RL, Keene, JD, and Ohler, U. "PARalyzer: definition of RNA binding sites from PAR-CLIP short-read sequence data. (Published online)" Genome Biol 12, no. 8 (August 18, 2011): R79-. Full Text Link to Item
  - Mukherjee, N, Corcoran, DL, Nusbaum, JD, Reid, DW, Georgiev, S, Hafner, M, Ascano, M, Tuschl, T, Ohler, U, and Keene, JD. "Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability." Mol Cell 43, no. 3 (August 5, 2011): 327-339. Full Text Link to Item
  - Mazan-Mamczarz, K, Hagner, PR, Zhang, Y, Dai, B, Lehrmann, E, Becker, KG, Keene, JD, Gorospe, M, Liu, Z, and Gartenhaus, RB. "ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes." Blood 117, no. 8 (2011): 2441-2450. Full Text
  - Neplioueva, V, Dobrikova, EY, Mukherjee, N, Keene, JD, and Gromeier, M. "Tissue type-specific expression of the dsRNA-binding protein 76 and genome-wide elucidation of its target mRNAs. (Published online)" PLoS One 5, no. 7 (July 23, 2010): e11710-. Full Text Open Access Copy Link to Item
  - Keene, JD. "The global dynamics of RNA stability orchestrates responses to cellular activation. (Published online)" BMC Biol 8 (July 8, 2010): 95-. Full Text Link to Item
  - Keene, JD. "Minireview: global regulation and dynamics of ribonucleic Acid." Endocrinology 151, no. 4 (April 2010): 1391-1397. (Review) Full Text Link to Item
  - Morris, AR, Mukherjee, N, and Keene, JD. "Systematic analysis of posttranscriptional gene expression." Wiley Interdiscip Rev Syst Biol Med 2, no. 2 (March 2010): 162-180. (Review) Full Text Link to Item
  - Graner, MW, Alzate, O, Dechkovskaia, AM, Keene, JD, Sampson, JH, Mitchell, DA, and Bigner, DD. "Proteomic and immunologic analyses of brain tumor exosomes." FASEB J 23, no. 5 (May 2009): 1541-1557. Full Text Link to Item
  - Mansfield, KD, and Keene, JD. "The ribonome: a dominant force in co-ordinating gene expression." Biol Cell 101, no. 3 (March 2009): 169-181. (Review) Full Text Link to Item
  - Mukherjee, N, Lager, PJ, Friedersdorf, MB, Thompson, MA, and Keene, JD. "Coordinated posttranscriptional mRNA population dynamics during T-cell activation." Mol Syst Biol 5 (2009): 288-. Full Text Link to Item
  - Papadaki, O, Milatos, S, Grammenoudi, S, Mukherjee, N, Keene, JD, and Kontoyiannis, DL. "Control of thymic T cell maturation, deletion and egress by the RNA-binding protein HuR." Journal of Immunology 182, no. 11 (2009): 6779-6788. Full Text
  - Tiruchinapalli, DM, Caron, MG, and Keene, JD. "Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain." J Neurochem 107, no. 6 (December 2008): 1529-1543. Full Text Link to Item
  - Tiruchinapalli, DM, Ehlers, MD, and Keene, JD. "Activity-dependent expression of RNA binding protein HuD and its association with mRNAs in neurons." RNA Biol 5, no. 3 (July 2008): 157-168. Link to Item
  - Morris, AR, Mukherjee, N, and Keene, JD. "Ribonomic analysis of human Pum1 reveals cis-trans conservation across species despite evolution of diverse mRNA target sets." Mol Cell Biol 28, no. 12 (June 2008): 4093-4103. Full Text Link to Item
  - Pyhtila, B, Zheng, T, Lager, PJ, Keene, JD, Reedy, MC, and Nicchitta, CV. "Signal sequence- and translation-independent mRNA localization to the endoplasmic reticulum." RNA 14, no. 3 (March 2008): 445-453. Full Text Link to Item
  - Beach, DL, and Keene, JD. "Ribotrap: Targeted purification of RNA-specific RNPs from cell lysates through immunoaffinity precipitation to identify regulatory proteins and RNAs." Methods in Molecular Biology 419 (2008): 69-91. Full Text
  - Mazan-Mamczarz, K, Hagner, PR, Corl, S, Srikantan, S, Wood, WH, Becker, KG, Gorospe, M, Keene, JD, Levenson, AS, and Gartenhaus, RB. "Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype." Oncogene 27, no. 47 (2008): 6151-6163. Full Text
  - Mazroui, R, Marco, SD, Clair, E, Roretz, CV, Tenenbaum, SA, Keene, JD, Saleh, M, and Gallouzi, I-E. "Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis." Journal of Cell Biology 180, no. 1 (2008): 113-127. Full Text
  - Keene, JD. "RNA regulons: coordination of post-transcriptional events." Nat Rev Genet 8, no. 7 (July 2007): 533-543. (Review) Full Text Link to Item
  - Keene, JD. "Biological clocks and the coordination theory of RNA operons and regulons." Cold Spring Harb Symp Quant Biol 72 (2007): 157-165. (Review) Full Text Link to Item
  - Konopka, JL, Penalva, LO, Thompson, JM, White, LJ, Beard, CW, Keene, JD, and Johnston, RE. "A two-phase innate host response to alphavirus infection identified by mRNP-tagging in vivo." PLoS pathogens 3, no. 12 (2007): e199-. Full Text
  - Konopka, JL, Penalva, LO, Thompson, JM, White, LJ, Beard, CW, Keene, JD, and Johnston, RE. "A two-phase innate host response to alphavirus infection identified by mRNP-tagging in vivo." PLoS Pathogens 3, no. 12 (2007): 2038-2051. Full Text
  - Keene, JD, Komisarow, JM, and Friedersdorf, MB. "Erratum: RIP-Chip: The isolation and identification of mRNAs, microRNAS and protein components of ribonucleoprotein complexes from cell extracts (Nature Protocols (2006) vol. 1 (302-307) 10.1038/nprot.2006.47)." Nature Protocols 1, no. 1 (2006).
  - Keene, JD, Komisarow, JM, and Friedersdorf, MB. "RIP-Chip: the isolation and identification of mRNAs, microRNAs and protein components of ribonucleoprotein complexes from cell extracts." Nat Protoc 1, no. 1 (2006): 302-307. Full Text Link to Item
  - Stephens, SB, Dodd, RD, Brewer, JW, Lager, PJ, Keene, JD, and Nicchitta, CV. "Stable ribosome binding to the endoplasmic reticulum enables compartment-specific regulation of mRNA translation." Mol Biol Cell 16, no. 12 (December 2005): 5819-5831. Full Text Link to Item
  - Keene, JD, and Lager, PJ. "Erratum: Posttranscriptional operons and regulons coordinating gene expression (Chromosome Research (2005) 13:3 (327-337))." Chromosome Research 13, no. 4 (2005): 424--.
  - Keene, JD, and Lager, PJ. "Post-transcriptional operons and regulons co-ordinating gene expression." Chromosome Res 13, no. 3 (2005): 327-337. (Review) Full Text Link to Item
  - Penalva, LOF, and Keene, JD. "Biotinylated tags for recovery and characterization of ribonucleoprotein complexes." Biotechniques 37, no. 4 (October 2004): 604-610. Link to Item
  - Penalva, LOF, Burdick, MD, Lin, SM, Sutterluety, H, and Keene, JD. "RNA-binding proteins to assess gene expression states of co-cultivated cells in response to tumor cells. (Published online)" Mol Cancer 3 (September 7, 2004): 24-. Full Text Link to Item
  - Hallett, M, II, LHP, Schomer, DL, and Massey, JM. "Preface." Supplements to Clinical Neurophysiology 57, no. C (2004): v-. Full Text
  - Keene, JD. "Microbiology and Molecular Biology Reviews: Note from the editor in chief." Microbiology and Molecular Biology Reviews 68, no. 2 (2004): i-.
  - Kenan, DJ, and Keene, JD. "La gets its wings." Nature Structural and Molecular Biology 11, no. 4 (2004): 303-305. Full Text
  - Mesarovic, MD, Sreenath, SN, and Keene, JD. "Search for organising principles: understanding in systems biology." Systems biology 1, no. 1 (2004): 19-27. Full Text
  - Penalva, LOF, Tenenbaum, SA, and Keene, JD. "Gene expression analysis of messenger RNP complexes." Methods Mol Biol 257 (2004): 125-134. Full Text Link to Item
  - Keene, JD. "Posttranscriptional generation of macromolecular complexes." Mol Cell 12, no. 6 (December 2003): 1347-1349. Link to Item
  - Tenenbaum, SA, Carson, CC, Atasoy, U, and Keene, JD. "Genome-wide regulatory analysis using en masse nuclear run-ons and ribonomic profiling with autoimmune sera." Gene 317, no. 1-2 (October 23, 2003): 79-87. Link to Item
  - Lerner, RS, Seiser, RM, Zheng, T, Lager, PJ, Reedy, MC, Keene, JD, and Nicchitta, CV. "Partitioning and translation of mRNAs encoding soluble proteins on membrane-bound ribosomes." RNA 9, no. 9 (September 2003): 1123-1137. Link to Item
  - Intine, RV, Tenenbaum, SA, Sakulich, AL, Keene, JD, and Maraia, RJ. "Differential phosphorylation and subcellular localization of La RNPs associated with precursor tRNAs and translation-related mRNAs." Molecular Cell 12, no. 5 (2003): 1301-1307. Full Text
  - Keene, JD. "Organizing mRNA export." Nature Genetics 33, no. 2 (2003): 111-112. Full Text
  - Mazan-Mamczarz, K, Galbán, S, Silanes, ILD, Martindale, JL, Atasoy, U, Keene, JD, and Gorospe, M. "RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation." Proceedings of the National Academy of Sciences of the United States of America 100, no. 14 (2003): 8354-8359. Full Text
  - Keene, JD, and Tenenbaum, SA. "Eukaryotic mRNPs may represent posttranscriptional operons." Mol Cell 9, no. 6 (June 2002): 1161-1167. Link to Item
  - Lipes, BD, and Keene, JD. "Autoimmune epitopes in messenger RNA." RNA 8, no. 6 (June 2002): 762-771. Link to Item
  - Tenenbaum, SA, Lager, PJ, Carson, CC, and Keene, JD. "Ribonomics: identifying mRNA subsets in mRNP complexes using antibodies to RNA-binding proteins and genomic arrays." Methods 26, no. 2 (February 2002): 191-198. Full Text Link to Item
  - Eystathioy, T, Chan, EKL, Tenenbaum, SA, Keene, JD, Griffith, K, and Fritzler, MJ. "A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles." Molecular Biology of the Cell 13, no. 4 (2002): 1338-1351. Full Text
  - Keene, JD. "Ribonucleoprotein infrastructure regulating the flow of genetic information between the genome and the proteome." Proc Natl Acad Sci U S A 98, no. 13 (June 19, 2001): 7018-7024. (Review) Full Text Link to Item
  - Brown, V, Jin, P, Ceman, S, Darnell, JC, O'Donnell, WT, Tenenbaum, SA, Jin, X, Feng, Y, Wilkinson, KD, Keene, JD, Darnell, RB, and Warren, ST. "Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome." Cell 107, no. 4 (2001): 477-487. Full Text
  - Tenenbaum, SA, Carson, CC, Lager, PJ, and Keene, JD. "Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays." Proc Natl Acad Sci U S A 97, no. 26 (December 19, 2000): 14085-14090. Full Text Link to Item
  - Nagai, Y, Tucker, T, Ren, H, Kenan, DJ, Henderson, BS, Keene, JD, Strittmatter, WJ, and Burke, JR. "Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening." J Biol Chem 275, no. 14 (April 7, 2000): 10437-10442. Link to Item
  - Ali, N, Pruijn, GJM, Kenan, DJ, Keene, JD, and Siddiqui, A. "Human La antigen is required for the hepatitis C virus internal ribosome entry site-mediated translation." Journal of Biological Chemistry 275, no. 36 (2000): 27531-27540. Full Text
  - Antic, D, Lu, N, and Keene, JD. "ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells." Genes Dev 13, no. 4 (February 15, 1999): 449-461. Link to Item
  - Keene, JD. "Why is Hu where? Shuttling of early-response-gene messenger RNA subsets." Proc Natl Acad Sci U S A 96, no. 1 (January 5, 1999): 5-7. Link to Item
  - Andrews, LG, and Keene, JD. "Identification of specific protein-RNA target sites using libraries of natural sequences." Methods in molecular biology (Clifton, N.J.) 118 (1999): 233-244.
  - Ford, LP, Watson, J, Keene, JD, and Wilusz, J. "ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system." Genes and Development 13, no. 2 (1999): 188-201.
  - Kenan, DJ, and Keene, JD. "In vitro selection of aptamers from RNA libraries." Methods Mol Biol 118 (1999): 217-231. Full Text Link to Item
  - Atasoy, U, Watson, J, Patel, D, and Keene, JD. "ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation." J Cell Sci 111 ( Pt 21) (November 1998): 3145-3156. Link to Item
  - Antic, D, and Keene, JD. "Messenger ribonucleoprotein complexes containing human ELAV proteins: interactions with cytoskeleton and translational apparatus." J Cell Sci 111 ( Pt 2) (January 1998): 183-197. Link to Item
  - Antic, D, and Keene, JD. "Embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression." Am J Hum Genet 61, no. 2 (August 1997): 273-278. (Review) Full Text Link to Item
  - Jain, RG, Andrews, LG, McGowan, KM, Pekala, PH, and Keene, JD. "Ectopic expression of Hel-N1, an RNA-binding protein, increases glucose transporter (GLUT1) expression in 3T3-L1 adipocytes." Molecular and Cellular Biology 17, no. 2 (1997): 954-962.
  - Keene, JD. "RNA surfaces as functional mimetics of proteins." Chem Biol 3, no. 7 (July 1996): 505-513. (Review) Link to Item
  - Gao, FB, and Keene, JD. "Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation." J Cell Sci 109 ( Pt 3) (March 1996): 579-589. Link to Item
  - Das, S, Kenan, DJ, Bocskai, D, Keene, JD, and Dasgupta, A. "Sequences within a small yeast RNA required for inhibition of internal initiation of translation: Interaction with La and other cellular proteins influences its inhibitory activity." Journal of Virology 70, no. 3 (1996): 1624-1632.
  - Keene, JD. "Letters." Scientist 10, no. 16 (1996).
  - Keene, JD. "RNA recognition by autoantigens and autoantibodies." Mol Biol Rep 23, no. 3-4 (1996): 173-181. (Review) Link to Item
  - Keene, JD. "Randomization and selection of RNA to identify targets for RRM RNA-binding proteins and antibodies." Methods Enzymol 267 (1996): 367-383. Link to Item
  - Méthot, N, Pickett, G, Keene, JD, and Sonenberg, N. "In vitro RNA selection identifies RNA ligands that specifically bind to eukaryotic translation initiation factor 4B: The role of the RNA recognition motif." RNA 2, no. 1 (1996): 38-50.
  - Romac, JM, and Keene, JD. "Overexpression of the arginine-rich carboxy-terminal region of U1 snRNP 70K inhibits both splicing and nucleocytoplasmic transport of mRNA." Genes Dev 9, no. 11 (June 1, 1995): 1400-1410. Link to Item
  - Chang, Y-N, Kenan, DJ, Keene, JD, Gatignol, A, and Jeang, K-T. "Erratum: Direct interactions between autoantigen La and human immunodeficiency virus leader RNA (Journal of Virology 68:11 (7014))." Journal of Virology 69, no. 1 (1995): 618-619.
  - Jain, RG, Andrews, LG, McGowan, KM, Gao, F, Keene, JD, and Pekala, PP. "Hel-N1, an RNA-binding protein, is a ligand for an A + U rich region of the GLUT1 3' UTR." Nucleic acids symposium series , no. 33 (1995): 209-211.
  - Gao, FB, Carson, CC, Levine, T, and Keene, JD. "Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1." Proc Natl Acad Sci U S A 91, no. 23 (November 8, 1994): 11207-11211. Link to Item
  - Romac, JM, Graff, DH, and Keene, JD. "The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear localization signal in the RNA-binding domain." Mol Cell Biol 14, no. 7 (July 1994): 4662-4670. Link to Item
  - Saitta, MR, Arnett, FC, and Keene, JD. "60-kDa Ro protein autoepitopes identified using recombinant polypeptides." J Immunol 152, no. 8 (April 15, 1994): 4192-4202. Link to Item
  - Kelekar, A, Saitta, MR, and Keene, JD. "Molecular composition of Ro small ribonucleoprotein complexes in human cells. Intracellular localization of the 60- and 52-kD proteins." J Clin Invest 93, no. 4 (April 1994): 1637-1644. Full Text Link to Item
  - King, PH, Levine, TD, Fremeau, RT, and Keene, JD. "Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor." J Neurosci 14, no. 4 (April 1994): 1943-1952. Link to Item
  - Kenan, DJ, Tsai, DE, and Keene, JD. "Exploring molecular diversity with combinatorial shape libraries." Trends Biochem Sci 19, no. 2 (February 1994): 57-64. (Review) Full Text Link to Item
  - Chang, Y-N, Kenan, DJ, Keene, JD, Gatignol, A, and Jeang, K-T. "Direct interactions between autoantigen La and human immunodeficiency virus leader RNA." Journal of Virology 68, no. 11 (1994): 7008-7020.
  - Maraia, RJ, Kenan, DJ, and Keene, JD. "Eukaryotic transcription termination factor La mediates transcript release and facilitates reinitiation by RNA polymerase III." Molecular and Cellular Biology 14, no. 3 (1994): 2147-2158.
  - Levine, TD, Gao, F, King, PH, Andrews, LG, and Keene, JD. "Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs." Mol Cell Biol 13, no. 6 (June 1993): 3494-3504. Link to Item
  - Tsai, DE, and Keene, JD. "In vitro selection of RNA epitopes using autoimmune patient serum." J Immunol 150, no. 3 (February 1, 1993): 1137-1145. Link to Item
  - Meerovitch, K, Svitkin, YV, Lee, HS, Lejbkowicz, F, Kenan, DJ, Chan, EKL, Agol, VI, Keene, JD, and Sonenberg, N. "La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate." Journal of Virology 67, no. 7 (1993): 3798-3807.
  - Tsai, DE, Kenan, DJ, and Keene, JD. "In vitro selection of an RNA epitope immunologically cross-reactive with a peptide." Proc Natl Acad Sci U S A 89, no. 19 (October 1, 1992): 8864-8868. Link to Item
  - Harper, DS, Fresco, LD, and Keene, JD. "RNA binding specificity of a Drosophila snRNP protein that shares sequence homology with mammalian U1-A and U2-B" proteins." Nucleic Acids Res 20, no. 14 (July 25, 1992): 3645-3650. Link to Item
  - Saitta, MR, and Keene, JD. "Molecular biology of nuclear autoantigens." Rheum Dis Clin North Am 18, no. 2 (May 1992): 283-310. (Review) Link to Item
  - Tsai, DE, Harper, DS, and Keene, JD. "U1-snRNP-A protein selects a ten nucleotide consensus sequence from a degenerate RNA pool presented in various structural contexts." Nucleic Acids Res 19, no. 18 (September 25, 1991): 4931-4936. Link to Item
  - Kenan, DJ, Query, CC, and Keene, JD. "RNA recognition: towards identifying determinants of specificity." Trends Biochem Sci 16, no. 6 (June 1991): 214-220. Link to Item
  - Bentley, RC, and Keene, JD. "Recognition of U1 and U2 small nuclear RNAs can be altered by a 5-amino-acid segment in the U2 small nuclear ribonucleoprotein particle (snRNP) B" protein and through interactions with U2 snRNP-A' protein." Mol Cell Biol 11, no. 4 (April 1991): 1829-1839. Link to Item
  - Hoffman, DW, Query, CC, Golden, BL, White, SW, and Keene, JD. "RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins." Proc Natl Acad Sci U S A 88, no. 6 (March 15, 1991): 2495-2499. Link to Item
  - St Clair, EW, Kenan, D, Burch, JA, Keene, JD, and Pisetsky, DS. "Anti-La antibody production by MRL-1pr/1pr mice. Analysis of fine specificity." J Immunol 146, no. 6 (March 15, 1991): 1885-1892. Link to Item
  - Fresco, LD, Harper, DS, and Keene, JD. "Leucine periodicity of U2 small nuclear ribonucleoprotein particle (snRNP) A' protein is implicated in snRNP assembly via protein-protein interactions." Mol Cell Biol 11, no. 3 (March 1991): 1578-1589. Link to Item
  - Keene, JD, and Query, CC. "Nuclear RNA-binding proteins." Prog Nucleic Acid Res Mol Biol 41 (1991): 179-202. (Review) Link to Item
  - Tamura, H-O, Kohchi, C, Yamada, R, Ikeda, T, Koiwai, O, Patterson, E, Keene, JD, Okada, K, Kjeldsen, E, Nishikawa, K, and Andoh, T. "Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites." Nucleic Acids Research 19, no. 1 (1991): 69-75.
  - Lutz-Freyermuth, C, Query, CC, and Keene, JD. "Quantitative determination that one of two potential RNA-binding domains of the A protein component of the U1 small nuclear ribonucleoprotein complex binds with high affinity to stem-loop II of U1 RNA." Proc Natl Acad Sci U S A 87, no. 16 (August 1990): 6393-6397. Link to Item
  - St Clair, EW, Kenan, D, Burch, JA, Keene, JD, and Pisetsky, DS. "The fine specificity of anti-La antibodies induced in mice by immunization with recombinant human La autoantigen." J Immunol 144, no. 10 (May 15, 1990): 3868-3876. Link to Item
  - St Clair, EW, Burch, JA, Ward, MM, Keene, JD, and Pisetsky, DS. "Temporal correlation of antibody responses to different epitopes of the human La autoantigen." J Clin Invest 85, no. 2 (February 1990): 515-521. Full Text Link to Item
  - St Clair, EW, Query, CC, Bentley, R, Keene, JD, Polisson, RP, Allen, NB, Caldwell, DS, Rice, JR, Cox, C, and Pisetsky, DS. "Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus." Clin Immunol Immunopathol 54, no. 2 (February 1990): 266-280. Link to Item
  - Harper, DS, Fresco, LD, and Keene, JD. "Characterization of a Drosophila U snRNP RNA-binding protein." Mol Biol Rep 14, no. 2-3 (1990): 163-. Link to Item
  - James, JA, Dickey, WD, Fujisaku, A, O'Brien, CA, Deutscher, SL, Keene, JD, and Harley, JB. "Antigenicity of a recombinant Ro (SS-A) fusion protein." Arthritis and Rheumatism 33, no. 1 (1990): 102-106. Full Text
  - Kelekar, A, and Keene, JD. "Downregulation of RNA polymerase III transcription of the hY3 gene in vitro." Mol Biol Rep 14, no. 2-3 (1990): 173-174. Link to Item
  - Sunde, L, Kjeldsen, E, Andoh, T, Keene, JD, and Bolund, L. "A three allele TaqI polymorphism at TOP1 gene." Nucleic Acids Research 18, no. 19 (1990): 5919--.
  - Query, CC, Bentley, RC, and Keene, JD. "A specific 31-nucleotide domain of U1 RNA directly interacts with the 70K small nuclear ribonucleoprotein component." Mol Cell Biol 9, no. 11 (November 1989): 4872-4881. Link to Item
  - Crone, DE, and Keene, JD. "Viral transcription is necessary and sufficient for vesicular stomatitis virus to inhibit maturation of small nuclear ribonucleoproteins." J Virol 63, no. 10 (October 1989): 4172-4180. Link to Item
  - Frielle, DW, Kim, PB, and Keene, JD. "Inhibitory effects of vesicular stomatitis virus on cellular and influenza viral RNA metabolism and protein synthesis." Virology 172, no. 1 (September 1989): 274-284. Link to Item
  - Keene, JD. "Molecular structure of the La and Ro autoantigens and their use in autoimmune diagnostics." J Autoimmun 2, no. 4 (August 1989): 329-334. (Review) Link to Item
  - St Clair, EW, Talal, N, Moutsopoulos, HM, Ballester, A, Zerva, L, Keene, JD, and Pisetsky, DS. "Epitope specificity of anti-La antibodies from patients with Sjögren's syndrome." J Autoimmun 2, no. 4 (August 1989): 335-344. Link to Item
  - Lutz-Freyermuth, C, and Keene, JD. "The U1 RNA-binding site of the U1 small nuclear ribonucleoprotein (snRNP)-associated A protein suggests a similarity with U2 snRNPs." Mol Cell Biol 9, no. 7 (July 1989): 2975-2982. Link to Item
  - Query, CC, Bentley, RC, and Keene, JD. "A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein." Cell 57, no. 1 (April 7, 1989): 89-101. Link to Item
  - St Clair, EW, Pisetsky, DS, Reich, CF, and Keene, JD. "Analysis of autoantibody binding to different regions of the human La antigen expressed in recombinant fusion proteins." J Immunol 141, no. 12 (December 15, 1988): 4173-4180. Link to Item
  - Chambers, JC, Kenan, D, Martin, BJ, and Keene, JD. "Genomic structure and amino acid sequence domains of the human La autoantigen." J Biol Chem 263, no. 34 (December 5, 1988): 18043-18051. Link to Item
  - Deutscher, SL, Harley, JB, and Keene, JD. "Molecular analysis of the 60-kDa human Ro ribonucleoprotein." Proc Natl Acad Sci U S A 85, no. 24 (December 1988): 9479-9483. Link to Item
  - Deutscher, SL, and Keene, JD. "A sequence-specific conformational epitope on U1 RNA is recognized by a unique autoantibody." Proc Natl Acad Sci U S A 85, no. 10 (May 1988): 3299-3303. Link to Item
  - St Clair, EW, Pisetsky, DS, Reich, CF, Chambers, JC, and Keene, JD. "Quantitative immunoassay of anti-La antibodies using purified recombinant La antigen." Arthritis Rheum 31, no. 4 (April 1988): 506-514. Link to Item
  - Query, CC, and Keene, JD. "A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen." Cell 51, no. 2 (October 23, 1987): 211-220. Link to Item
  - Chambers, JC, and Keene, JD. "Association between autoimmune epitopes and RNA binding domains of the human Lupus La protein." Molecular Biology Reports 12, no. 3 (1987): 241--. Full Text
  - Deutscher, SL, Harley, JB, and Keene, JD. "Molecular characterization of the Ro small cytoplasmic RNPS." Molecular Biology Reports 12, no. 3 (1987): 242--. Full Text
  - Fresco, LD, Kurilla, MG, and Keene, JD. "Rapid inhibition of processing and assembly of small nuclear ribonucleoproteins after infection with vesicular stomatitis virus." Molecular and Cellular Biology 7, no. 3 (1987): 1148-1155.
  - Fresco, LD, and Keene, JD. "Molecular analysis of the U2 snRNP unique protein A′." Molecular Biology Reports 12, no. 3 (1987): 155--. Full Text
  - Keene, JD, Deutscher, SL, Kenan, D, and Kelekar, A. "Nature of the la and ro RNPs." Molecular Biology Reports 12, no. 3 (1987): 235-238. Full Text
  - Query, CC, and Keene, JD. "The U1 RNA-specific 70K protein: RNA-binding studies and autoimmune cross-reactivity with type-C retroviruses." Molecular Biology Reports 12, no. 3 (1987): 158--. Full Text
  - Kiley, MP, Wilusz, J, Cormick, JBM, and Keene, JD. "Conservation of the 3′ terminal nucleotide sequences of Ebola and Marburg virus." Virology 149, no. 2 (1986): 251-254.
  - Wilusz, J, and Keene, JD. "Autoantibodies specific for U1 RNA and initiator methionine tRNA." Journal of Biological Chemistry 261, no. 12 (1986): 5467-5472.
  - Pisetsky, DS, Hoch, SO, Klatt, CL, O'Donnell, MA, and Keene, JD. "Specificity and idiotypic analysis of a monoclonal anti-Sm antibody with anti-DNA activity." J Immunol 135, no. 6 (December 1985): 4080-4085. Link to Item
  - Keene, JD. "Interactions between small viral RNAs of vesicular stomatitis virus and components of cellular gene expression." Microbiol Sci 2, no. 5 (May 1985): 152-156. (Review) Link to Item
  - Chambers, JC, and Keene, JD. "Isolation and analysis of cDNA clones expressing human lupus La antigen." Proceedings of the National Academy of Sciences of the United States of America 82, no. 7 (1985): 2115-2119.
  - Kole, R, Fresco, LD, Keene, JD, Cohen, PL, Eisenberg, RA, and Andrews, PG. "Alu RNA-protein complexes formed in vitro react with a novel lupus autoantibody." Journal of Biological Chemistry 260, no. 21 (1985): 11781-11786.
  - Kurilla, MG, Stone, HO, and Keene, JD. "RNA sequence and transcriptional properties of the 3′ end of the Newcastle disease virus genome." Virology 145, no. 2 (1985): 203-212.
  - Piwnica-Worms, H, and Keene, JD. "Replication of the vesicular stomatitis virus genome in permissive and nonpermissive host cells." Journal of Biological Chemistry 260, no. 19 (1985): 10503-10511.
  - Wilusz, J, Youngner, JS, and Keene, JD. "Base mutations in the terminal noncoding regions of the genome of vesicular stomatitis virus isolated from persistent infections of L cells." Virology 140, no. 2 (1985): 249-256.
  - Kurilla, MG, Cabradilla, CD, Holloway, BP, and Keene, JD. "Nucleotide sequence and host La protein interactions of rabies virus leader RNA." Journal of Virology 50, no. 3 (1984): 773-778.
  - Meier, E, Harmison, GG, Keene, JD, and Schubert, M. "Sites of copy choice replication involved in generation of vesicular stomatitis virus defective-interfering particle RNAs." Journal of Virology 51, no. 2 (1984): 515-521.
  - Wilusz, J, and Keene, JD. "Interactions of plus and minus strand leader RNAs of the New Jersey serotype of vesicular stomatitis virus with the cellular La protein." Virology 135, no. 1 (1984): 65-73.
  - Chambers, JC, Kurilla, MG, and Keene, JD. "Association between the 7 S RNA and the lupus La protein varies among cell types." Journal of Biological Chemistry 258, no. 19 (1983): 11438-11441.
  - Kurilla, MG, and Keene, JD. "The leader RNA of vesicular stomatitis virus is bound by a cellular protein reactive with anti-La lupus antibodies." Cell 34, no. 3 (1983): 837-845.
  - Piwnica-Worms, H, and Keene, JD. "Sequential synthesis of small capped RNA transcripts in Vitro by vesicular stomatitis virus." Virology 125, no. 1 (1983): 206-218.
  - Wilusz, J, Kurilla, MG, and Keene, JD. "A host protein (La) binds to a unique species of minus-sense leader RNA during replication of vesicular stomatitis virus." Proceedings of the National Academy of Sciences of the United States of America 80, no. 19 I (1983): 5827-5831.
  - Gaillard, RK, Li, JK, Keene, JD, and Joklik, WK. "The sequence at the termini of four genes of the three reovirus serotypes." Virology 121, no. 2 (September 1982): 320-326. Link to Item
  - Isaac, CL, and Keene, JD. "RNA polymerase-associated interactions near template promoter sequences of defective interfering particles of vesicular stomatitis virus." Journal of Virology 43, no. 1 (1982): 241-249.
  - Kurilla, MG, Piwnica-Worms, H, and Keene, JD. "Rapid and transient localization of the leader RNA of vesicular stomatitis virus in the nuclei of infected cells." Proceedings of the National Academy of Sciences of the United States of America 79, no. 17 I (1982): 5240-5244.
  - Lazzarini, RA, Chien, I, Yang, F, and Keene, JD. "The metabolic fate of independently initiated VSV mRNA transcripts." Journal of General Virology 58, no. 2 (1982): 429-441.
  - Schmidt, EV, Keene, JD, Linial, M, and Smith, RE. "Association of 3′ terminal RNA sequences with avian leukosis viruses causing a high incidence of osteopetrosis." Virology 116, no. 1 (1982): 163-180.
  - Isaac, CL, and Keene, JD. "Transfer RNAs associated with vesicular stomatitis virus." Journal of General Virology 56, no. 1 (1981): 141-151.
  - Keene, JD, Chien, IM, and Lazzarini, RA. "Vesicular stomatitis virus defective interfering particle containing a muted internal leader RNA gene." Proceedings of the National Academy of Sciences of the United States of America 78, no. 4 II (1981): 2090-2094.
  - Keene, JD, Thornton, BJ, and Emerson, SU. "Sequence-specific contacts between the RNA polymerase of vesicular stomatitis virus and the leader RNA gene." Proceedings of the National Academy of Sciences of the United States of America 78, no. 10 I (1981): 6191-6195.
  - Lazzarini, RA, Keene, JD, and Schubert, M. "The origins of defective interfering particles of the negative-strand RNA viruses." Cell 26, no. 2 PART 2 (January 1, 1981): 145-154. (Review) Full Text
  - Lazzarini, RA, Keene, JD, and Schubert, M. "The origins of defective interfering particles of the negative-strand RNA viruses." Cell 26, no. 2 PART 2 (1981): 145-154.
  - Li, JK, Keene, JD, Scheible, PP, and Joklik, WK. "Nature of the 3'-terminal sequences of the plus and minus strands of the S1 gene of reovirus serotypes 1, 2 and 3." Virology 105, no. 1 (August 1980): 41-51. Link to Item
  - Li, JK, Scheible, PP, Keene, JD, and Joklik, WK. "The plus strand of reovirus gene S2 is identical with its in vitro transcript." Virology 105, no. 1 (August 1980): 282-286. Link to Item
  - Herman, RC, Schubert, M, Keene, JD, and Lazzarini, RA. "Polycistronic vesicular stomatitis virus RNA transcripts." Proceedings of the National Academy of Sciences of the United States of America 77, no. 8 (1980): 4662-4665.
  - Keene, JD, Schubert, M, and Lazzarini, RA. "Intervening sequence between the leader region and the nucleocapsid gene of vesicular stomatitis virus RNA." Journal of Virology 33, no. 2 (1980): 789-794.
  - Schubert, M, Keene, JD, Herman, RC, and Lazzarini, RA. "Site on the vesicular stomatitis virus genome specifying polyadenylation and the end of the L gene mRNA." Journal of Virology 34, no. 2 (1980): 550-559.
  - Keene, JD, Schubert, M, and Lazzarini, RA. "Terminal sequences of vesicular stomatitis virus RNA are both complementary and conserved." Journal of Virology 32, no. 1 (1979): 167-174.
  - Schubert, M, Keene, JD, and Lazzarini, RA. "A specific internal RNA polymerase recognition site of VSV RNA is involved in the generation of DI particles." Cell 18, no. 3 (1979): 749-757.
  - Keene, JD, Schubert, M, Lazzarini, RA, and Rosenberg, M. "Nucleotide sequence homology at the 3' termini of RNA from vesicular stomatitis virus and its defective interfering particles." Proceedings of the National Academy of Sciences of the United States of America 75, no. 7 (1978): 3225-3229.
  - Schubert, M, Keene, JD, Lazzarini, RA, and Emerson, SU. "The complete sequence of a unique rna species synthesized by a DI particle of VSV." Cell 15, no. 1 (1978): 103-112.
  - Colonno, RJ, Lazzarini, RA, Keene, JD, and Banerjee, AK. "In vitro synthesis of messenger RNA by a defective interfering particle of vesicular stomatitis virus." Proceedings of the National Academy of Sciences of the United States of America 74, no. 5 (1977): 1884-1888.
  - Keene, JD, Rosenberg, M, and Lazzarini, RA. "Characterization of the 3' terminus of RNA isolated from vesicular stomatitis virus and from its defective interfering particles." Proceedings of the National Academy of Sciences of the United States of America 74, no. 4 (1977): 1353-1357.
  - Keene, JD, and Lazzarini, RA. "A comparison of the extents of methylation of vesicular stomatitis virus messenger RNA." Virology 69, no. 1 (1976): 364-367.
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- Duke University. Provost's Committee on Named Professorships. 2003 - 2006 2003 - 2006
- Duke Comprehensive Cancer Center. Director of Basic Science. 1995 - 2003 1995 - 2003
- Departmental Chair. Administrative. Duke University Medical Center. 1992 - 2002 1992 - 2002

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