RNA recognition: towards identifying determinants of specificity.

Published

Journal Article

Members of a family of proteins containing a conserved approximately 80-amino acid RNA recognition motif (RRM) bind specifically to a wide variety of RNA molecules. Structural studies, in combination with sequence alignments, indicate the structural context of both conserved and non-conserved elements in the motif. These analyses suggest that all RRM proteins share a common fold and a similar protein-RNA interface, and that non-conserved residues contribute additional contacts for sequence-specific RNA recognition.

Full Text

Duke Authors

Cited Authors

  • Kenan, DJ; Query, CC; Keene, JD

Published Date

  • June 1991

Published In

Volume / Issue

  • 16 / 6

Start / End Page

  • 214 - 220

PubMed ID

  • 1716386

Pubmed Central ID

  • 1716386

International Standard Serial Number (ISSN)

  • 0968-0004

Digital Object Identifier (DOI)

  • 10.1016/0968-0004(91)90088-d

Language

  • eng

Conference Location

  • England