Transcription as a source of genome instability.

Journal Article (Journal Article;Review)

Alterations in genome sequence and structure contribute to somatic disease, affect the fitness of subsequent generations and drive evolutionary processes. The crucial roles of highly accurate replication and efficient repair in maintaining overall genome integrity are well-known, but the more localized stability costs that are associated with transcribing DNA into RNA molecules are less appreciated. Here we review the diverse ways in which the essential process of transcription alters the underlying DNA template and thereby modifies the genetic landscape.

Full Text

Duke Authors

Cited Authors

  • Kim, N; Jinks-Robertson, S

Published Date

  • February 14, 2012

Published In

Volume / Issue

  • 13 / 3

Start / End Page

  • 204 - 214

PubMed ID

  • 22330764

Pubmed Central ID

  • PMC3376450

Electronic International Standard Serial Number (EISSN)

  • 1471-0064

Digital Object Identifier (DOI)

  • 10.1038/nrg3152


  • eng

Conference Location

  • England