SAMMA, a mandelic acid condensation polymer, inhibits dendritic cell-mediated HIV transmission.

Published

Journal Article

SAMMA, a mandelic acid condensation polymer, exhibits a broad antimicrobial activity against several sexually transmitted pathogens including human immunodeficiency virus (HIV). Here we demonstrated that SAMMA suppressed HIV transmission by dendritic cells (DCs), one of the first target cells for primary infection. The greatest inhibitory effect was achieved when SAMMA was present during the co-culture with target cells. The inhibitory effect of SAMMA on DC-mediated HIV transmission was not due to cytotoxicity. Analysis of the level of DC-associated HIV p24 antigen revealed that SAMMA prevented HIV internalization by DCs when the virus was pre-incubated with the compound. In contrast, pre-incubation of DCs with SAMMA followed by wash-off did not affect the amount of cell-associated HIV p24 antigen. In addition, SAMMA blocked HIV glycoprotein-mediated cell-cell fusion. This study suggests that SAMMA prevents HIV infection through multiple mechanisms.

Full Text

Duke Authors

Cited Authors

  • Chang, TL; Teleshova, N; Rapista, A; Paluch, M; Anderson, RA; Waller, DP; Zaneveld, LJD; Granelli-Piperno, A; Klotman, ME

Published Date

  • October 2, 2007

Published In

Volume / Issue

  • 581 / 24

Start / End Page

  • 4596 - 4602

PubMed ID

  • 17825297

Pubmed Central ID

  • 17825297

International Standard Serial Number (ISSN)

  • 0014-5793

Digital Object Identifier (DOI)

  • 10.1016/j.febslet.2007.08.048

Language

  • eng

Conference Location

  • England