Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy.

Journal Article (Journal Article)

The phenotype of HIV-1 gp120 envelope derived from renal epithelium and peripheral blood mononuclear cells (PBMC) of patients with HIV-associated nephropathy was investigated in vitro. Chimeric viruses were derived from kidney or blood and used to infect primary CD4+T cells, cell lines expressing single co-receptors and a renal epithelial cell line HPT-1. HIV-1 variants derived from renal epithelium were dual tropic whereas simultaneously derived viruses from PBMC were R5-tropic. Utilization of alternative co-receptors CCR3, BONZO and BOB, also differed.

Full Text

Duke Authors

Cited Authors

  • Zerhouni-Layachi, B; Husain, M; Ross, MJ; Marras, D; Sunamoto, M; Liu, X; Klotman, PE; Klotman, ME

Published Date

  • February 28, 2006

Published In

Volume / Issue

  • 20 / 4

Start / End Page

  • 621 - 624

PubMed ID

  • 16470129

International Standard Serial Number (ISSN)

  • 0269-9370

Digital Object Identifier (DOI)

  • 10.1097/01.aids.0000210618.68083.8e


  • eng

Conference Location

  • England