Development of topical microbicides for prevention of human immunodeficiency virus and herpes simplex virus.


Journal Article (Review)

Topical microbicides, designed for vaginal or rectal administration, are needed to prevent human immunodeficiency virus (HIV) and other sexually transmitted infections (STI). Presently marketed topical microbicides are cytotoxic and damage the vaginal epithelium with frequent use. Rational development of new candidate compounds should build on knowledge of the pathways of microbial invasion. The establishment of assays and models that predict efficacy and safety is critical. Comprehensive pre-clinical evaluation of promising microbicides should include rigorous assessment of the effects of repeated application of topical agents on mucosal inflammatory cells, cytokines, and the genital tract virus population. These studies will lay the groundwork for future clinical trials.

Full Text

Duke Authors

Cited Authors

  • Keller, MJ; Klotman, ME; Herold, BC

Published Date

  • May 2003

Published In

Volume / Issue

  • 49 / 5

Start / End Page

  • 279 - 284

PubMed ID

  • 12854732

Pubmed Central ID

  • 12854732

International Standard Serial Number (ISSN)

  • 1046-7408

Digital Object Identifier (DOI)

  • 10.1034/j.1600-0897.2003.00044.x


  • eng

Conference Location

  • Denmark