Psychometric study of the Aberrant Behavior Checklist in Fragile X Syndrome and implications for targeted treatment.

Journal Article (Journal Article)

Animal studies elucidating the neurobiology of fragile X syndrome (FXS) have led to multiple controlled trials in humans, with the Aberrant Behavior Checklist-Community (ABC-C) commonly adopted as a primary outcome measure. A multi-site collaboration examined the psychometric properties of the ABC-C in 630 individuals (ages 3-25) with FXS using exploratory and confirmatory factor analysis. Results support a six-factor structure, with one factor unchanged (Inappropriate Speech), four modified (Irritability, Hyperactivity, Lethargy/Withdrawal, and Stereotypy), and a new Social Avoidance factor. A comparison with ABC-C data from individuals with general intellectual disability and a list of commonly endorsed items are also reported. Reformulated ABC-C scores based on this FXS-specific factor structure may provide added outcome measure specificity and sensitivity in FXS clinical trials.

Full Text

Duke Authors

Cited Authors

  • Sansone, SM; Widaman, KF; Hall, SS; Reiss, AL; Lightbody, A; Kaufmann, WE; Berry-Kravis, E; Lachiewicz, A; Brown, EC; Hessl, D

Published Date

  • July 2012

Published In

Volume / Issue

  • 42 / 7

Start / End Page

  • 1377 - 1392

PubMed ID

  • 21972117

Pubmed Central ID

  • PMC3290710

Electronic International Standard Serial Number (EISSN)

  • 1573-3432

Digital Object Identifier (DOI)

  • 10.1007/s10803-011-1370-2


  • eng

Conference Location

  • United States