Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., University of Minnesota, Twin Cities 1980
• 

  Duke Appointment History

  • Associate Professor of Pediatrics, Pediatrics, Clinical Science Departments 2006 - 2015
  • Assistant Clinical Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2001 - 2006
  • Assistant Clinical Professor of Pediatrics, Pediatrics, Clinical Science Departments 1994 - 2006
• Research
• 

  Selected Grants

  • Alcobra AL014 Fraglie X Study awarded by Alcobra Ltd. 2014 - 2015
  • Candidate Gene Analysis of Persistent AD/HD awarded by National Institutes of Health 2004 - 2010
  • What about adolescence? Living with genetic risk awarded by National Institutes of Health 2004 - 2007
  • Phenotypic Markers in Females with Fragile X Premutation awarded by National Institutes of Health 2001 - 2003
• Publications & Artistic Works
• 

  Selected Publications

  • Journal Articles

    • Kidd, SA, Lachiewicz, A, Barbouth, D, Blitz, RK, Delahunty, C, McBrien, D, Visootsak, J, and Berry-Kravis, E. "Fragile X syndrome: a review of associated medical problems." Pediatrics 134, no. 5 (November 2014): 995-1005. (Review)  Full Text
    • Sansone, SM, Widaman, KF, Hall, SS, Reiss, AL, Lightbody, A, Kaufmann, WE, Berry-Kravis, E, Lachiewicz, A, Brown, EC, and Hessl, D. "Psychometric study of the aberrant behavior checklist in fragile X syndrome and implications for targeted treatment." Journal of Autism and Developmental Disorders 42, no. 7 (2012): 1377-1392.  Full Text
    • Lachiewicz, A, Dawson, D, Spiridigliozzi, G, Cuccaro, M, Lachiewicz, M, and McConkie-Rosell, A. "Indicators of anxiety and depression in women with the fragile X premutation: assessment of a clinical sample." J Intellect Disabil Res 54, no. 7 (July 2010): 597-610.  Full Text  Link to Item
    • Markunas, CA, Quinn, KS, Collins, AL, Garrett, ME, Lachiewicz, AM, Sommer, JL, Morrissey-Kane, E, Kollins, SH, Anastopoulos, AD, and Ashley-Koch, AE. "Genetic variants in SLC9A9 are associated with measures of attention-deficit/hyperactivity disorder symptoms in families." Psychiatric Genetics 20, no. 2 (April 2010): 73-81.  Full Text
    • Kollins, SH, Garrett, ME, McClernon, FJ, Lachiewicz, AM, Morrissey-Kane, E, FitzGerald, D, Collins, AL, Anastopoulos, AD, and Ashley-Koch, AE. "Effects of postnatal parental smoking on parent and teacher ratings of ADHD and oppositional symptoms." The Journal of Nervous and Mental Disease 197, no. 6 (June 2009): 442-449.  Full Text
    • Hagerman, RJ, Berry-Kravis, E, Kaufmann, WE, Ono, MY, Tartaglia, N, Lachiewicz, A, Kronk, R, Delahunty, C, Hessl, D, Visootsak, J, Picker, J, Gane, L, and Tranfaglia, M. "Advances in the treatment of fragile X syndrome." Pediatrics 123, no. 1 (January 2009): 378-390. (Review)  Full Text
    • Kollins, SH, Anastopoulos, AD, Lachiewicz, AM, FitzGerald, D, Morrissey-Kane, E, Garrett, ME, Keatts, SL, and Ashley-Koch, AE. "SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families." Am J Med Genet B Neuropsychiatr Genet 147B, no. 8 (December 5, 2008): 1580-1588.  Full Text  Link to Item
    • Lachiewicz, AM, Berwick, M, Wiggins, CL, and Thomas, NE. "Epidemiologic support for melanoma heterogeneity using the surveillance, epidemiology, and end results program." J Invest Dermatol 128, no. 5 (May 2008): 1340-1342. (Letter)  Full Text  Link to Item
    • Lachiewicz, AM, Berwick, M, Wiggins, CL, and Thomas, NE. "Survival differences between patients with scalp or neck melanoma and those with melanoma of other sites in the Surveillance, Epidemiology, and End Results (SEER) program." Archives of Dermatology 144, no. 4 (April 2008): 515-521.  Full Text
    • McConkie-Rosell, A, Spiridigliozzi, GA, Melvin, E, Dawson, DV, and Lachiewicz, AM. "Living with genetic risk: effect on adolescent self-concept." American Journal of Medical Genetics. Part C, Seminars in Medical Genetics 148C, no. 1 (February 2008): 56-69.  Full Text
    • Lachiewicz, AM, Berwick, M, Wiggins, CL, and Thomas, NE. "Epidemiologic support for melanoma heterogeneity using the Surveillance, Epidemiology, and End Results Program." The Journal of Investigative Dermatology 128, no. 1 (January 2008): 243-245. (Letter)  Full Text
    • Lachiewicz, AM, and Lachiewicz, PF. "Weight and activity change in overweight and obese patients after primary total knee arthroplasty." J Arthroplasty 23, no. 1 (January 2008): 33-40.  Full Text  Link to Item
    • Lachiewicz, AM, Wilkinson, TM, Groben, P, Ollila, DW, and Thomas, NE. "Muir-Torre syndrome." Am J Clin Dermatol 8, no. 5 (2007): 315-319.  Link to Item
    • Lachiewicz, AM, Dawson, DV, Spiridigliozzi, GA, and McConkie-Rosell, A. "Arithmetic difficulties in females with the fragile X premutation." Am J Med Genet A 140, no. 7 (April 1, 2006): 665-672.  Full Text  Link to Item
    • McConkie-Rosell, A, Spiridigliozzi, GA, Sullivan, JA, Dawson, DV, and Lachiewicz, AM. "Carrier testing in fragile X syndrome: when to tell and test." Am J Med Genet 110, no. 1 (June 1, 2002): 36-44.  Full Text  Link to Item
    • McConkie-Rosell, A, Spiridigliozzi, GA, Sullivan, JA, Dawson, DV, and Lachiewicz, AM. "Longitudinal study of the carrier testing process for fragile X syndrome: perceptions and coping." Am J Med Genet 98, no. 1 (January 1, 2001): 37-45.  Link to Item
    • Tassone, F, Hagerman, RJ, Loesch, DZ, Lachiewicz, A, Taylor, AK, and Hagerman, PJ. "Fragile X males with unmethylated, full mutation trinucleotide repeat expansions have elevated levels of FMR1 messenger RNA." American journal of medical genetics 94, no. 3 (September 2000): 232-236.  Full Text
    • McConkie-Rosell, A, Spiridigliozzi, GA, Sullivan, JA, Dawson, DV, and Lachiewicz, AM. "Carrier testing in fragile X syndrome: effect on self-concept." Am J Med Genet 92, no. 5 (June 19, 2000): 336-342.  Link to Item
    • Lachiewicz, AM, Dawson, DV, and Spiridigliozzi, GA. "Physical characteristics of young boys with fragile X syndrome: reasons for difficulties in making a diagnosis in young males." American Journal of Medical Genetics 92, no. 4 (June 2000): 229-236.  Full Text
    • Tassone, F, Hagerman, RJ, Loesch, DZ, Lachiewicz, A, Taylor, AK, and Hagerman, PJ. "Fragile X males with unmethylated, full mutation trinucleotide repeat expansions have elevated levels of FMR1 messenger RNA." American Journal of Medical Genetics 94, no. 3 (2000): 232-236.  Full Text
    • McConkie-Rosell, A, Spiridigliozzi, GA, Rounds, K, Dawson, DV, Sullivan, JA, Burgess, D, and Lachiewicz, AM. "Parental attitudes regarding carrier testing in children at risk for fragile X syndrome." Am J Med Genet 82, no. 3 (January 29, 1999): 206-211.  Link to Item
    • Hatton, DD, Buckley, E, Lachiewicz, A, and Roberts, J. "Ocular status of boys with fragile X syndrome: A prospective study." Journal of AAPOS 2, no. 5 (1998): 298-302.
    • McConkie-Rosell, A, Spiridigliozzi, GA, Iafolla, T, Tarleton, J, and Lachiewicz, AM. "Carrier testing in the fragile X syndrome: attitudes and opinions of obligate carriers." American Journal of Medical Genetics 68, no. 1 (January 1997): 62-69.  Full Text
    • Lachiewicz, AM, Spiridigliozzi, GA, McConkie-Rosell, A, Burgess, D, Feng, Y, Warren, ST, and Tarleton, J. "A fragile X male with a broad smear on Southern blot analysis representing 100-500 CGG repeats and no methylation at the EagI site of the FMR-1 gene." American Journal of Medical Genetics 64, no. 2 (August 1996): 278-282.  Full Text
    • Dykens, E, Ort, S, Cohen, I, Finucane, B, Spiridigliozzi, G, Lachiewicz, A, Reiss, A, Freund, L, Hagerman, R, and O'Connor, R. "Trajectories and profiles of adaptive behavior in males with fragile X syndrome: Multicenter studies." Journal of Autism and Developmental Disorders 26, no. 3 (1996): 287-301.  Full Text
    • Van Hove, JL, Kishnani, P, Muenzer, J, Wenstrup, RJ, Summar, ML, Brummond, MR, Lachiewicz, AM, Millington, DS, and Kahler, SG. "Benzoate therapy and carnitine deficiency in non-ketotic hyperglycinemia." Am J Med Genet 59, no. 4 (December 4, 1995): 444-453.  Full Text  Link to Item
    • Lachiewicz, AM. "Females with fragile X syndrome: A review of the effects of an abnormal FMR1 gene." Mental Retardation and Developmental Disabilities Research Reviews 1, no. 4 (1995): 292-297.  Full Text
    • Mazzocco, MMM, Lachiewicz, AM, Kovar, CG, Freund, LS, Baumgardner, TL, and Dykens, E. "Psychological and emotional studies of the fragile X mutation. A workshop summary." Developmental Brain Dysfunction 8, no. 4-6 (1995): 396-404.
    • Albright, SG, Lachiewicz, AM, Tarleton, JC, Rao, KW, Schwartz, CE, Richie, R, Tennison, MB, and Aylsworth, AS. "Fragile X phenotype in a patient with a large de novo deletion in Xq27-q28." Am J Med Genet 51, no. 4 (July 15, 1994): 294-297.  Full Text  Link to Item
    • Lachiewicz, AM, and Dawson, DV. "Behavior problems of young girls with fragile X syndrome: factor scores on the Conners' Parent's Questionnaire." Am J Med Genet 51, no. 4 (July 15, 1994): 364-369.  Full Text  Link to Item
    • Lachiewicz, AM, and Dawson, DV. "Do young boys with fragile X syndrome have macroorchidism?." Pediatrics 93, no. 6 Pt 1 (June 1994): 992-995.  Link to Item
    • Lachiewicz, AM, Spiridigliozzi, GA, Gullion, CM, Ransford, SN, and Rao, K. "Aberrant behaviors of young boys with fragile X syndrome." Am J Ment Retard 98, no. 5 (March 1994): 567-579.  Link to Item
    • Lachiewicz, AM, and Dawson, DV. "Do young boys with fragile X syndrome have macroorchidism?." Pediatrics 93, no. 6 I (1994): 992-995.
    • Tarleton, J, Richie, R, Schwartz, C, Rao, K, Aylsworth, AS, and Lachiewicz, A. "An extensive de novo deletion removing FMR1 in a patient with mental retardation and the fragile X syndrome phenotype." Human Molecular Genetics 2, no. 11 (November 1993): 1973-1974.  Full Text
    • McConkie-Rosell, A, Lachiewicz, AM, Spiridigliozzi, GA, Tarleton, J, Schoenwald, S, Phelan, MC, Goonewardena, P, Ding, X, and Brown, WT. "Evidence that methylation of the FMR-I locus is responsible for variable phenotypic expression of the fragile X syndrome." Am J Hum Genet 53, no. 4 (October 1993): 800-809.  Link to Item
    • Lachiewicz, AM. "Abnormal behaviors of young girls with fragile X syndrome." Am J Med Genet 43, no. 1-2 (April 15, 1992): 72-77.  Link to Item
    • Reiss, AL, Cianchetti, C, Cohen, IL, DeVries, B, Hagerman, R, Hinton, V, Froster, U, Lachiewicz, A, Mazzocco, M, Sobesky, W, and Sudhalter, V. "Brief screening questionnaire for determining affected state in fragile X syndrome: A consensus recommendation." American Journal of Medical Genetics 43, no. 1-2 (1992): 61-64.  Full Text
    • Lachiewicz, AM, Hoegerman, SF, Holmgren, G, Holmberg, E, and Arinbjarnarson, K. "Association of the Robin sequence with the fragile X syndrome." Am J Med Genet 41, no. 3 (December 1, 1991): 275-278.  Full Text  Link to Item
    • Cameron, TH, Lachiewicz, AM, and Aylsworth, AS. "Townes-Brocks syndrome in two mentally retarded youngsters." Am J Med Genet 41, no. 1 (October 1, 1991): 1-4.  Full Text  Link to Item
    • Hodapp, RM, Dykens, EM, Hagerman, RJ, Schreiner, R, Lachiewicz, AM, and Leckman, JF. "Developmental implications of changing trajectories of IQ in males with fragile X syndrome." Journal of the American Academy of Child and Adolescent Psychiatry 29, no. 2 (March 1990): 214-219.  Full Text
    • Lachiewicz, A, Harrison, C, Spiridigliozzi, GA, Callanan, NP, and Livermore, J. "What is the fragile X syndrome?." N C Med J 49, no. 4 (April 1988): 203-208. (Review)  Link to Item
    • Lachiewicz, AM, Gullion, CM, Spiridigliozzi, GA, and Aylsworth, AS. "Declining IQs of young males with the fragile X syndrome." American Journal of Mental Retardation : Ajmr 92, no. 3 (November 1987): 272-278.
    • Lachiewicz, AM, Sibley, R, and Michael, AF. "Hereditary renal disease and preauricular pits: report of a kindred." J Pediatr 106, no. 6 (June 1985): 948-950.  Link to Item
    • Lachiewicz, AM, Kogan, SJ, Levitt, SB, and Weiner, RL. "Concurrent agenesis of the corpus callosum and ureteroceles in siblings." Pediatrics 75, no. 5 (May 1985): 904-907.  Link to Item

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