Ave Maria Lachiewicz | Scholars@Duke

Ave Maria Lachiewicz
Associate Professor Emeritus of Pediatrics

Clinician for children with developmental concerns such as ADHD, autism, apraxia, fragile X syndrome.

Current Appointments & Affiliations

Associate Professor Emeritus of Pediatrics, Pediatrics, Neurology, Pediatrics 2022

Contact Information

3000 Erwin Rd, Trent Dr., Durham, NC 27705
Box 3364 Med Ctr, Durham, NC 27710
ave.lachiewicz@duke.edu (919) 668-4468

Background
Education, Training, & Certifications
- M.D., University of Minnesota, Twin Cities 1980
Previous Appointments & Affiliations
- Associate Professor of Pediatrics, Pediatrics, Neurology, Pediatrics 2015 - 2022
- Assistant Professor in Psychiatry and Behavioral Sciences, Psychiatry, Child & Family Mental Health & Community Psychiatry, Psychiatry & Behavioral Sciences 2021 - 2022
- Assistant Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2020 - 2021
- Assistant Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2006 - 2020
- Associate Professor of Pediatrics, Pediatrics, Clinical Science Departments 2006 - 2015
- Assistant Clinical Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2001 - 2006
- Assistant Clinical Professor of Pediatrics, Pediatrics, Clinical Science Departments 1994 - 2006
Recognition
Awards & Honors
- North Carolina's Top Doctors. Business North Carolina. July 2021
Expertise
Subject Headings
- Fragile X Syndrome
Research
Selected Grants
- Using Longitudinal Data to Characterize the Natural History of Fragile X Syndrome - Component A awarded by National Fragile X Foundation 2020 - 2021
- A 6-Week, Randomized, Multicenter, Double-Blind, Parallel, Flexed- and Fixed-dose Study of MG01CI (Metadoxine Extended-Release) 700 Mg and 1400 Mg Compared with Placebo in Adults and Adolescents with Fragile X Syndrome awarded by Alcobra Ltd. 2014 - 2015
- Candidate Gene Analysis of Persistent AD/HD awarded by National Institutes of Health 2004 - 2010
- What about adolescence? Living with genetic risk awarded by National Institutes of Health 2004 - 2007
- Phenotypic Markers in Females with Fragile X Premutation awarded by National Institutes of Health 2001 - 2003
External Relationships
- Curio Sciences
- DWA Healthcare Communications
- Gerson Lehrman Group
- Guidepoint Global
- Innomed
- none
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Kaufmann, Walter E., Melissa Raspa, Carla M. Bann, Julia M. Gable, Holly K. Harris, Dejan B. Budimirovic, Reymundo Lozano, and Reymundo FORWARD Consortium. “Latent Class Analysis Identifies Distinctive Behavioral Subtypes in Children with Fragile X Syndrome.” J Autism Dev Disord, November 28, 2022. https://doi.org/10.1007/s10803-022-05821-7.
    Full Text Link to Item
  - Berry-Kravis, Elizabeth, Sharon A. Kidd, Ave M. Lachiewicz, Tse Hwei Choo, Nicole Tartaglia, Devadrita Talapatra, Christina Aguirre-Kolb, Howard Andrews, and Karen Riley. “Toilet Training in Fragile X Syndrome.” J Dev Behav Pediatr 40, no. 9 (December 2019): 751–61. https://doi.org/10.1097/DBP.0000000000000735.
    Full Text Link to Item
  - Kidd, Sharon A., Ave Lachiewicz, Deborah Barbouth, Robin K. Blitz, Carol Delahunty, Dianne McBrien, Jeannie Visootsak, and Elizabeth Berry-Kravis. “Fragile X syndrome: a review of associated medical problems.” Pediatrics 134, no. 5 (November 2014): 995–1005. https://doi.org/10.1542/peds.2013-4301.
    Full Text Link to Item
  - Sansone, Stephanie M., Keith F. Widaman, Scott S. Hall, Allan L. Reiss, Amy Lightbody, Walter E. Kaufmann, Elizabeth Berry-Kravis, Ave Lachiewicz, Elaine C. Brown, and David Hessl. “Psychometric study of the Aberrant Behavior Checklist in Fragile X Syndrome and implications for targeted treatment.” J Autism Dev Disord 42, no. 7 (July 2012): 1377–92. https://doi.org/10.1007/s10803-011-1370-2.
    Full Text Link to Item
  - Lachiewicz, Ave, D. Dawson, G. Spiridigliozzi, M. Cuccaro, M. Lachiewicz, and A. McConkie-Rosell. “Indicators of anxiety and depression in women with the fragile X premutation: assessment of a clinical sample.” J Intellect Disabil Res 54, no. 7 (July 2010): 597–610. https://doi.org/10.1111/j.1365-2788.2010.01290.x.
    Full Text Link to Item
  - Markunas, Christina A., Kaia S. Quinn, Ann L. Collins, Melanie E. Garrett, Ave M. Lachiewicz, Jennifer L. Sommer, Erin Morrissey-Kane, Scott H. Kollins, Arthur D. Anastopoulos, and Allison E. Ashley-Koch. “Genetic variants in SLC9A9 are associated with measures of attention-deficit/hyperactivity disorder symptoms in families.” Psychiatr Genet 20, no. 2 (April 2010): 73–81. https://doi.org/10.1097/YPG.0b013e3283351209.
    Full Text Link to Item
  - Kollins, Scott H., Melanie E. Garrett, F Joseph McClernon, Ave M. Lachiewicz, Erin Morrissey-Kane, David FitzGerald, Ann L. Collins, Arthur D. Anastopoulos, and Allison E. Ashley-Koch. “Effects of postnatal parental smoking on parent and teacher ratings of ADHD and oppositional symptoms.” J Nerv Ment Dis 197, no. 6 (June 2009): 442–49. https://doi.org/10.1097/NMD.0b013e3181a61d9e.
    Full Text Link to Item
  - Hagerman, Randi J., Elizabeth Berry-Kravis, Walter E. Kaufmann, Michele Y. Ono, Nicole Tartaglia, Ave Lachiewicz, Rebecca Kronk, et al. “Advances in the treatment of fragile X syndrome.” Pediatrics 123, no. 1 (January 2009): 378–90. https://doi.org/10.1542/peds.2008-0317.
    Full Text Link to Item
  - Kollins, S. H., A. D. Anastopoulos, A. M. Lachiewicz, D. FitzGerald, E. Morrissey-Kane, M. E. Garrett, S. L. Keatts, and A. E. Ashley-Koch. “SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families.” Am J Med Genet B Neuropsychiatr Genet 147B, no. 8 (December 5, 2008): 1580–88. https://doi.org/10.1002/ajmg.b.30876.
    Full Text Link to Item
  - Lachiewicz, Anne M., Marianne Berwick, Charles L. Wiggins, and Nancy E. Thomas. “Epidemiologic support for melanoma heterogeneity using the surveillance, epidemiology, and end results program.” J Invest Dermatol 128, no. 5 (May 2008): 1340–42. https://doi.org/10.1038/jid.2008.18.
    Full Text Link to Item
  - Lachiewicz, Anne M., Marianne Berwick, Charles L. Wiggins, and Nancy E. Thomas. “Survival differences between patients with scalp or neck melanoma and those with melanoma of other sites in the Surveillance, Epidemiology, and End Results (SEER) program.” Arch Dermatol 144, no. 4 (April 2008): 515–21. https://doi.org/10.1001/archderm.144.4.515.
    Full Text Link to Item
  - McConkie-Rosell, Allyn, Gail A. Spiridigliozzi, Elizabeth Melvin, Deborah V. Dawson, and Ave M. Lachiewicz. “Living with genetic risk: effect on adolescent self-concept.” Am J Med Genet C Semin Med Genet 148C, no. 1 (February 15, 2008): 56–69. https://doi.org/10.1002/ajmg.c.30161.
    Full Text Link to Item
  - Lachiewicz, Anne M., Marianne Berwick, Charles L. Wiggins, and Nancy E. Thomas. “Epidemiologic support for melanoma heterogeneity using the Surveillance, Epidemiology, and End Results Program.” J Invest Dermatol 128, no. 1 (January 2008): 243–45. https://doi.org/10.1038/sj.jid.5701028.
    Full Text Link to Item
  - Lachiewicz, Anne M., and Paul F. Lachiewicz. “Weight and activity change in overweight and obese patients after primary total knee arthroplasty.” J Arthroplasty 23, no. 1 (January 2008): 33–40. https://doi.org/10.1016/j.arth.2007.01.023.
    Full Text Link to Item
  - Lachiewicz, Anne M., Todd M. Wilkinson, Pamela Groben, David W. Ollila, and Nancy E. Thomas. “Muir-Torre syndrome.” Am J Clin Dermatol 8, no. 5 (2007): 315–19. https://doi.org/10.2165/00128071-200708050-00008.
    Full Text Link to Item
  - Lachiewicz, Ave M., Deborah V. Dawson, Gail A. Spiridigliozzi, and Allyn McConkie-Rosell. “Arithmetic difficulties in females with the fragile X premutation.” Am J Med Genet A 140, no. 7 (April 1, 2006): 665–72. https://doi.org/10.1002/ajmg.a.31082.
    Full Text Link to Item
  - McConkie-Rosell, Allyn, Gail A. Spiridigliozzi, Jennifer A. Sullivan, Deborah V. Dawson, and Ave M. Lachiewicz. “Carrier testing in fragile X syndrome: when to tell and test.” Am J Med Genet 110, no. 1 (June 1, 2002): 36–44. https://doi.org/10.1002/ajmg.10396.
    Full Text Link to Item
  - McConkie-Rosell, A., G. A. Spiridigliozzi, J. A. Sullivan, D. V. Dawson, and A. M. Lachiewicz. “Longitudinal study of the carrier testing process for fragile X syndrome: perceptions and coping.” Am J Med Genet 98, no. 1 (January 1, 2001): 37–45.
    Link to Item
  - Tassone, F., R. J. Hagerman, D. Z. Loesch, A. Lachiewicz, A. K. Taylor, and P. J. Hagerman. “Fragile X males with unmethylated, full mutation trinucleotide repeat expansions have elevated levels of FMR1 messenger RNA.” Am J Med Genet 94, no. 3 (September 18, 2000): 232–36. https://doi.org/10.1002/1096-8628(20000918)94:3<232::aid-ajmg9>3.0.co;2-h.
    Full Text Link to Item
  - McConkie-Rosell, A., G. A. Spiridigliozzi, J. A. Sullivan, D. V. Dawson, and A. M. Lachiewicz. “Carrier testing in fragile X syndrome: effect on self-concept.” Am J Med Genet 92, no. 5 (June 19, 2000): 336–42. https://doi.org/10.1002/1096-8628(20000619)92:5<336::aid-ajmg8>3.0.co;2-l.
    Full Text Link to Item
  - Lachiewicz, A. M., D. V. Dawson, and G. A. Spiridigliozzi. “Physical characteristics of young boys with fragile X syndrome: reasons for difficulties in making a diagnosis in young males.” Am J Med Genet 92, no. 4 (June 5, 2000): 229–36. https://doi.org/10.1002/(sici)1096-8628(20000605)92:4<229::aid-ajmg1>3.0.co;2-k.
    Full Text Link to Item
  - McConkie-Rosell, A., G. A. Spiridigliozzi, K. Rounds, D. V. Dawson, J. A. Sullivan, D. Burgess, and A. M. Lachiewicz. “Parental attitudes regarding carrier testing in children at risk for fragile X syndrome.” Am J Med Genet 82, no. 3 (January 29, 1999): 206–11.
    Link to Item
  - Hatton, D. D., E. Buckley, A. Lachiewicz, and J. Roberts. “Ocular status of boys with fragile X syndrome: a prospective study.” J Aapos 2, no. 5 (October 1998): 298–302. https://doi.org/10.1016/s1091-8531(98)90087-8.
    Full Text Link to Item
  - McConkie-Rosell, A., G. A. Spiridigliozzi, T. Iafolla, J. Tarleton, and A. M. Lachiewicz. “Carrier testing in the fragile X syndrome: attitudes and opinions of obligate carriers.” Am J Med Genet 68, no. 1 (January 10, 1997): 62–69. https://doi.org/10.1002/(sici)1096-8628(19970110)68:1<62::aid-ajmg12>3.0.co;2-m.
    Full Text Link to Item
  - Lachiewicz, A. M., G. A. Spiridigliozzi, A. McConkie-Rosell, D. Burgess, Y. Feng, S. T. Warren, and J. Tarleton. “A fragile X male with a broad smear on Southern blot analysis representing 100-500 CGG repeats and no methylation at the EagI site of the FMR-1 gene.” Am J Med Genet 64, no. 2 (August 9, 1996): 278–82. https://doi.org/10.1002/(SICI)1096-8628(19960809)64:2<278::AID-AJMG9>3.0.CO;2-Q.
    Full Text Link to Item
  - Dykens, E., S. Ort, I. Cohen, B. Finucane, G. Spiridigliozzi, A. Lachiewicz, A. Reiss, L. Freund, R. Hagerman, and R. O’Connor. “Trajectories and profiles of adaptive behavior in males with fragile X syndrome: multicenter studies.” J Autism Dev Disord 26, no. 3 (June 1996): 287–301. https://doi.org/10.1007/BF02172475.
    Full Text Link to Item
  - Van Hove, J. L., P. Kishnani, J. Muenzer, R. J. Wenstrup, M. L. Summar, M. R. Brummond, A. M. Lachiewicz, D. S. Millington, and S. G. Kahler. “Benzoate therapy and carnitine deficiency in non-ketotic hyperglycinemia.” Am J Med Genet 59, no. 4 (December 4, 1995): 444–53. https://doi.org/10.1002/ajmg.1320590410.
    Full Text Link to Item
  - Mazzocco, M. M. M., A. M. Lachiewicz, C. G. Kovar, L. S. Freund, T. L. Baumgardner, and E. Dykens. “Psychological and emotional studies of the fragile X mutation. A workshop summary.” Developmental Brain Dysfunction 8, no. 4–6 (December 1, 1995): 396–404.
  - Lachiewicz, A. M. “Females with fragile X syndrome: A review of the effects of an abnormal FMR1 gene.” Mental Retardation and Developmental Disabilities Research Reviews 1, no. 4 (January 1, 1995): 292–97. https://doi.org/10.1002/mrdd.1410010411.
    Full Text
  - Albright, S. G., A. M. Lachiewicz, J. C. Tarleton, K. W. Rao, C. E. Schwartz, R. Richie, M. B. Tennison, and A. S. Aylsworth. “Fragile X phenotype in a patient with a large de novo deletion in Xq27-q28.” Am J Med Genet 51, no. 4 (July 15, 1994): 294–97. https://doi.org/10.1002/ajmg.1320510403.
    Full Text Link to Item
  - Lachiewicz, A. M., and D. V. Dawson. “Behavior problems of young girls with fragile X syndrome: factor scores on the Conners' Parent's Questionnaire.” Am J Med Genet 51, no. 4 (July 15, 1994): 364–69. https://doi.org/10.1002/ajmg.1320510413.
    Full Text Link to Item
  - LACHIEWICZ, A. M., and D. V. DAWSON. “DO YOUNG BOYS WITH FRAGILE-X-SYNDROME HAVE MACROORCHIDISM.” Pediatrics 93, no. 6 (June 1, 1994): 992–95.
    Link to Item
  - Lachiewicz, A. M., and D. V. Dawson. “Do young boys with fragile X syndrome have macroorchidism?” Pediatrics 93, no. 6 Pt 1 (June 1994): 992–95.
    Link to Item
  - Lachiewicz, A. M., G. A. Spiridigliozzi, C. M. Gullion, S. N. Ransford, and K. Rao. “Aberrant behaviors of young boys with fragile X syndrome.” Am J Ment Retard 98, no. 5 (March 1994): 567–79.
    Link to Item
  - Lachiewicz, A. M., and D. V. Dawson. “Do young boys with fragile X syndrome have macroorchidism?” Pediatrics 93, no. 6 I (January 1, 1994): 992–95.
  - Tarleton, J., R. Richie, C. Schwartz, K. Rao, A. S. Aylsworth, and A. Lachiewicz. “An extensive de novo deletion removing FMR1 in a patient with mental retardation and the fragile X syndrome phenotype.” Hum Mol Genet 2, no. 11 (November 1993): 1973–74. https://doi.org/10.1093/hmg/2.11.1973.
    Full Text Link to Item
  - McConkie-Rosell, A., A. M. Lachiewicz, G. A. Spiridigliozzi, J. Tarleton, S. Schoenwald, M. C. Phelan, P. Goonewardena, X. Ding, and W. T. Brown. “Evidence that methylation of the FMR-I locus is responsible for variable phenotypic expression of the fragile X syndrome.” Am J Hum Genet 53, no. 4 (October 1993): 800–809.
    Link to Item
  - Lachiewicz, A. M. “Abnormal behaviors of young girls with fragile X syndrome.” Am J Med Genet 43, no. 1–2 (April 15, 1992): 72–77. https://doi.org/10.1002/ajmg.1320430111.
    Full Text Link to Item
  - Reiss, A. L., C. Cianchetti, I. L. Cohen, B. DeVries, R. Hagerman, V. Hinton, U. Froster, A. Lachiewicz, M. Mazzocco, and W. Sobesky. “Brief screening questionnaire for determining affected state in fragile X syndrome: a consensus recommendation.” Am J Med Genet 43, no. 1–2 (April 15, 1992): 61–64. https://doi.org/10.1002/ajmg.1320430109.
    Full Text Link to Item
  - Lachiewicz, A. M., S. F. Hoegerman, G. Holmgren, E. Holmberg, and K. Arinbjarnarson. “Association of the Robin sequence with the fragile X syndrome.” Am J Med Genet 41, no. 3 (December 1, 1991): 275–78. https://doi.org/10.1002/ajmg.1320410302.
    Full Text Link to Item
  - Cameron, T. H., A. M. Lachiewicz, and A. S. Aylsworth. “Townes-Brocks syndrome in two mentally retarded youngsters.” Am J Med Genet 41, no. 1 (October 1, 1991): 1–4. https://doi.org/10.1002/ajmg.1320410102.
    Full Text Link to Item
  - Hodapp, R. M., E. M. Dykens, R. J. Hagerman, R. Schreiner, A. M. Lachiewicz, and J. F. Leckman. “Developmental implications of changing trajectories of IQ in males with fragile X syndrome.” J Am Acad Child Adolesc Psychiatry 29, no. 2 (March 1990): 214–19. https://doi.org/10.1097/00004583-199003000-00009.
    Full Text Link to Item
  - LACHIEWICZ, A. M. “FRAGILE-X SYNDROME - A HANDBOOK FOR FAMILIES AND EDUCATORS - FINUCANE,B.” Journal of Autism and Developmental Disorders 19, no. 4 (December 1, 1989): 643–643.
    Link to Item
  - Lachiewicz, A., C. Harrison, G. A. Spiridigliozzi, N. P. Callanan, and J. Livermore. “What is the fragile X syndrome?” N C Med J 49, no. 4 (April 1988): 203–8.
    Link to Item
  - Lachiewicz, A. M., C. M. Gullion, G. A. Spiridigliozzi, and A. S. Aylsworth. “Declining IQs of young males with the fragile X syndrome.” Am J Ment Retard 92, no. 3 (November 1987): 272–78.
    Link to Item
  - Lachiewicz, A. M., C. M. Gullion, G. A. Spiridigliozzi, and A. S. Alysworth. “Decline in IQ Scores of Young Fragile X Males.” Journal of Developmental &Amp; Behavioral Pediatrics 7, no. 3 (June 1986): 201–201. https://doi.org/10.1097/00004703-198606000-00020.
    Full Text
  - Lachiewicz, A. M., R. Sibley, and A. F. Michael. “Hereditary renal disease and preauricular pits: report of a kindred.” J Pediatr 106, no. 6 (June 1985): 948–50. https://doi.org/10.1016/s0022-3476(85)80248-1.
    Full Text Link to Item
  - Lachiewicz, A. M., S. J. Kogan, S. B. Levitt, and R. L. Weiner. “Concurrent agenesis of the corpus callosum and ureteroceles in siblings.” Pediatrics 75, no. 5 (May 1985): 904–7.
    Link to Item
  - Lachiewicz, Ave. “Best Practices in Fragile X Syndrome. Treatment Development,” n.d. https://doi.org/10.3390/brainsci8120224.
    Full Text
- Conference Papers
  - DAWSON, D. V., and A. M. LACHIEWICZ. “BEHAVIORAL EPIDEMIOLOGY OF FRAGILE-X SYNDROME IN FEMALE PEDIATRIC POPULATIONS.” In American Journal of Epidemiology, 141:S50–S50. AMER J EPIDEMIOLOGY, 1995.
    Link to Item
  - LACHIEWICZ, A. M., and D. V. DAWSON. “AUTISTIC BEHAVIORS OF YOUNG GIRLS WITH FRAGILE X-SYNDROME.” In Pediatric Research, 35:A23–A23. WILLIAMS & WILKINS, 1994.
    Link to Item
  - LACHIEWICZ, A. M. “PHYSICAL CHARACTERISTICS OF YOUNG BOYS WITH FRAGILE-X SYNDROME.” In 1992 International Fragile X Conference Proceedings, edited by R. J. Hagerman and P. McKenzie, 29–36. SPECTRA PUBLISHING CO INC, 1992.
    Link to Item
  - LACHIEWICZ, A. M., G. A. SPIRIDIGLIOZZI, C. A. GULLION, and S. K. RANSFORD. “ABERRANT BEHAVIORS OF YOUNG BOYS WITH FRAGILE X-SYNDROME.” In Pediatric Research, 27:A12–A12. WILLIAMS & WILKINS, 1990.
    Link to Item
Artistic Works & Non-Print Media
- Prints
  - Stepping up to bat for the team. Writer. 2021
Scholarly, Clinical, & Service Activities
Clinical Activities
- Clinical activities involve working with children who have fragile X syndrome, ADHD, and autism.

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Previous Appointments & Affiliations

Awards & Honors

Subject Headings

Selected Grants

External Relationships

Selected Publications

Academic Articles

Conference Papers

Artistic Works & Non-Print Media

Prints

Clinical Activities