Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., University of Minnesota, Twin Cities 1980
• 

  Duke Appointment History

  • Associate Professor of Pediatrics, Pediatrics, Clinical Science Departments 2006 - 2015
  • Assistant Clinical Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2001 - 2006
  • Assistant Clinical Professor of Pediatrics, Pediatrics, Clinical Science Departments 1994 - 2006
• Expertise
• 

  Subject Headings

  • Fragile X Syndrome
• Research
• 

  Selected Grants

  • A 6-Week, Randomized, Multicenter, Double-Blind, Parallel, Flexed- and Fixed-dose Study of MG01CI (Metadoxine Extended-Release) 700 Mg and 1400 Mg Compared with Placebo in Adults and Adolescents with Fragile X Syndrome awarded by Alcobra Ltd. 2014 - 2015
  • Candidate Gene Analysis of Persistent AD/HD awarded by National Institutes of Health 2004 - 2010
  • What about adolescence? Living with genetic risk awarded by National Institutes of Health 2004 - 2007
  • Phenotypic Markers in Females with Fragile X Premutation awarded by National Institutes of Health 2001 - 2003
• 

  External Relationships

  • Deborah Wood Associates
  • Gerson Lehrman Group
  • Global Guidepoint
  • Heron Therapeutics
  • Innomed
  • Inspire One Communications
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Berry-Kravis, Elizabeth, Sharon A. Kidd, Ave M. Lachiewicz, Tse Hwei Choo, Nicole Tartaglia, Devadrita Talapatra, Christina Aguirre-Kolb, Howard Andrews, and Karen Riley. “Toilet Training in Fragile X Syndrome.” Journal of Developmental and Behavioral Pediatrics : Jdbp 40, no. 9 (December 2019): 751–61. https://doi.org/10.1097/dbp.0000000000000735.
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    • Erickson, C. A., W. E. Kaufmann, D. B. Budimirovic, A. Lachiewicz, B. Haas-Givler, R. M. Miller, J. Dixon Weber, et al. “Best practices in fragile X syndrome treatment development.” Brain Sciences 8, no. 12 (December 1, 2018). https://doi.org/10.3390/brainsci8120224.
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    • Kidd, Sharon A., Ave Lachiewicz, Deborah Barbouth, Robin K. Blitz, Carol Delahunty, Dianne McBrien, Jeannie Visootsak, and Elizabeth Berry-Kravis. “Fragile X syndrome: a review of associated medical problems.” Pediatrics 134, no. 5 (November 2014): 995–1005. https://doi.org/10.1542/peds.2013-4301.
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    • Sansone, Stephanie M., Keith F. Widaman, Scott S. Hall, Allan L. Reiss, Amy Lightbody, Walter E. Kaufmann, Elizabeth Berry-Kravis, Ave Lachiewicz, Elaine C. Brown, and David Hessl. “Psychometric study of the Aberrant Behavior Checklist in Fragile X Syndrome and implications for targeted treatment.” Journal of Autism and Developmental Disorders 42, no. 7 (July 2012): 1377–92. https://doi.org/10.1007/s10803-011-1370-2.
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    • Lachiewicz, Ave, D. Dawson, G. Spiridigliozzi, M. Cuccaro, M. Lachiewicz, and A. McConkie-Rosell. “Indicators of anxiety and depression in women with the fragile X premutation: assessment of a clinical sample.” J Intellect Disabil Res 54, no. 7 (July 2010): 597–610. https://doi.org/10.1111/j.1365-2788.2010.01290.x.
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    • Markunas, Christina A., Kaia S. Quinn, Ann L. Collins, Melanie E. Garrett, Ave M. Lachiewicz, Jennifer L. Sommer, Erin Morrissey-Kane, Scott H. Kollins, Arthur D. Anastopoulos, and Allison E. Ashley-Koch. “Genetic variants in SLC9A9 are associated with measures of attention-deficit/hyperactivity disorder symptoms in families.” Psychiatr Genet 20, no. 2 (April 2010): 73–81. https://doi.org/10.1097/YPG.0b013e3283351209.
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    • Kollins, Scott H., Melanie E. Garrett, F Joseph McClernon, Ave M. Lachiewicz, Erin Morrissey-Kane, David FitzGerald, Ann L. Collins, Arthur D. Anastopoulos, and Allison E. Ashley-Koch. “Effects of postnatal parental smoking on parent and teacher ratings of ADHD and oppositional symptoms.” J Nerv Ment Dis 197, no. 6 (June 2009): 442–49. https://doi.org/10.1097/NMD.0b013e3181a61d9e.
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    • Hagerman, Randi J., Elizabeth Berry-Kravis, Walter E. Kaufmann, Michele Y. Ono, Nicole Tartaglia, Ave Lachiewicz, Rebecca Kronk, et al. “Advances in the treatment of fragile X syndrome.” Pediatrics 123, no. 1 (January 2009): 378–90. https://doi.org/10.1542/peds.2008-0317.
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    • Kollins, S. H., A. D. Anastopoulos, A. M. Lachiewicz, D. FitzGerald, E. Morrissey-Kane, M. E. Garrett, S. L. Keatts, and A. E. Ashley-Koch. “SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families.” Am J Med Genet B Neuropsychiatr Genet 147B, no. 8 (December 5, 2008): 1580–88. https://doi.org/10.1002/ajmg.b.30876.
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    • Lachiewicz, Anne M., Marianne Berwick, Charles L. Wiggins, and Nancy E. Thomas. “Epidemiologic support for melanoma heterogeneity using the surveillance, epidemiology, and end results program.” J Invest Dermatol 128, no. 5 (May 2008): 1340–42. https://doi.org/10.1038/jid.2008.18.
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    • Lachiewicz, Anne M., Marianne Berwick, Charles L. Wiggins, and Nancy E. Thomas. “Survival differences between patients with scalp or neck melanoma and those with melanoma of other sites in the Surveillance, Epidemiology, and End Results (SEER) program.” Arch Dermatol 144, no. 4 (April 2008): 515–21. https://doi.org/10.1001/archderm.144.4.515.
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    • McConkie-Rosell, Allyn, Gail A. Spiridigliozzi, Elizabeth Melvin, Deborah V. Dawson, and Ave M. Lachiewicz. “Living with genetic risk: effect on adolescent self-concept.” Am J Med Genet C Semin Med Genet 148C, no. 1 (February 15, 2008): 56–69. https://doi.org/10.1002/ajmg.c.30161.
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    • Lachiewicz, Anne M., Marianne Berwick, Charles L. Wiggins, and Nancy E. Thomas. “Epidemiologic support for melanoma heterogeneity using the Surveillance, Epidemiology, and End Results Program.” J Invest Dermatol 128, no. 1 (January 2008): 243–45. https://doi.org/10.1038/sj.jid.5701028.
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    • Lachiewicz, Anne M., and Paul F. Lachiewicz. “Weight and activity change in overweight and obese patients after primary total knee arthroplasty.” J Arthroplasty 23, no. 1 (January 2008): 33–40. https://doi.org/10.1016/j.arth.2007.01.023.
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    • Lachiewicz, Anne M., Todd M. Wilkinson, Pamela Groben, David W. Ollila, and Nancy E. Thomas. “Muir-Torre syndrome.” Am J Clin Dermatol 8, no. 5 (2007): 315–19. https://doi.org/10.2165/00128071-200708050-00008.
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    • Lachiewicz, Ave M., Deborah V. Dawson, Gail A. Spiridigliozzi, and Allyn McConkie-Rosell. “Arithmetic difficulties in females with the fragile X premutation.” Am J Med Genet A 140, no. 7 (April 1, 2006): 665–72. https://doi.org/10.1002/ajmg.a.31082.
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    • McConkie-Rosell, Allyn, Gail A. Spiridigliozzi, Jennifer A. Sullivan, Deborah V. Dawson, and Ave M. Lachiewicz. “Carrier testing in fragile X syndrome: when to tell and test.” Am J Med Genet 110, no. 1 (June 1, 2002): 36–44. https://doi.org/10.1002/ajmg.10396.
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    • McConkie-Rosell, A., G. A. Spiridigliozzi, J. A. Sullivan, D. V. Dawson, and A. M. Lachiewicz. “Longitudinal study of the carrier testing process for fragile X syndrome: perceptions and coping.” Am J Med Genet 98, no. 1 (January 1, 2001): 37–45.
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    • Tassone, F., R. J. Hagerman, D. Z. Loesch, A. Lachiewicz, A. K. Taylor, and P. J. Hagerman. “Fragile X males with unmethylated, full mutation trinucleotide repeat expansions have elevated levels of FMR1 messenger RNA.” American Journal of Medical Genetics 94, no. 3 (September 2000): 232–36. https://doi.org/10.1002/1096-8628(20000918)94:3<232::aid-ajmg9>3.0.co;2-h.
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    • McConkie-Rosell, A., G. A. Spiridigliozzi, J. A. Sullivan, D. V. Dawson, and A. M. Lachiewicz. “Carrier testing in fragile X syndrome: effect on self-concept.” Am J Med Genet 92, no. 5 (June 19, 2000): 336–42. https://doi.org/10.1002/1096-8628(20000619)92:5<336::aid-ajmg8>3.0.co;2-l.
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    • Lachiewicz, A. M., D. V. Dawson, and G. A. Spiridigliozzi. “Physical characteristics of young boys with fragile X syndrome: reasons for difficulties in making a diagnosis in young males.” Am J Med Genet 92, no. 4 (June 5, 2000): 229–36. https://doi.org/10.1002/(sici)1096-8628(20000605)92:4<229::aid-ajmg1>3.0.co;2-k.
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    • McConkie-Rosell, A., G. A. Spiridigliozzi, K. Rounds, D. V. Dawson, J. A. Sullivan, D. Burgess, and A. M. Lachiewicz. “Parental attitudes regarding carrier testing in children at risk for fragile X syndrome.” Am J Med Genet 82, no. 3 (January 29, 1999): 206–11.
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    • Hatton, D. D., E. Buckley, A. Lachiewicz, and J. Roberts. “Ocular status of boys with fragile X syndrome: a prospective study.” J Aapos 2, no. 5 (October 1998): 298–302. https://doi.org/10.1016/s1091-8531(98)90087-8.
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    • McConkie-Rosell, A., G. A. Spiridigliozzi, T. Iafolla, J. Tarleton, and A. M. Lachiewicz. “Carrier testing in the fragile X syndrome: attitudes and opinions of obligate carriers.” Am J Med Genet 68, no. 1 (January 10, 1997): 62–69. https://doi.org/10.1002/(sici)1096-8628(19970110)68:1<62::aid-ajmg12>3.0.co;2-m.
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    • Lachiewicz, A. M., G. A. Spiridigliozzi, A. McConkie-Rosell, D. Burgess, Y. Feng, S. T. Warren, and J. Tarleton. “A fragile X male with a broad smear on Southern blot analysis representing 100-500 CGG repeats and no methylation at the EagI site of the FMR-1 gene.” Am J Med Genet 64, no. 2 (August 9, 1996): 278–82. https://doi.org/10.1002/(SICI)1096-8628(19960809)64:2<278::AID-AJMG9>3.0.CO;2-Q.
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    • Dykens, E., S. Ort, I. Cohen, B. Finucane, G. Spiridigliozzi, A. Lachiewicz, A. Reiss, L. Freund, R. Hagerman, and R. O’Connor. “Trajectories and profiles of adaptive behavior in males with fragile X syndrome: multicenter studies.” J Autism Dev Disord 26, no. 3 (June 1996): 287–301. https://doi.org/10.1007/BF02172475.
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    • Van Hove, J. L., P. Kishnani, J. Muenzer, R. J. Wenstrup, M. L. Summar, M. R. Brummond, A. M. Lachiewicz, D. S. Millington, and S. G. Kahler. “Benzoate therapy and carnitine deficiency in non-ketotic hyperglycinemia.” Am J Med Genet 59, no. 4 (December 4, 1995): 444–53. https://doi.org/10.1002/ajmg.1320590410.
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    • Mazzocco, M. M. M., A. M. Lachiewicz, C. G. Kovar, L. S. Freund, T. L. Baumgardner, and E. Dykens. “Psychological and emotional studies of the fragile X mutation. A workshop summary.” Developmental Brain Dysfunction 8, no. 4–6 (December 1, 1995): 396–404.
    • Lachiewicz, A. M. “Females with fragile X syndrome: A review of the effects of an abnormal FMR1 gene.” Mental Retardation and Developmental Disabilities Research Reviews 1, no. 4 (January 1, 1995): 292–97. https://doi.org/10.1002/mrdd.1410010411.
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    • Albright, S. G., A. M. Lachiewicz, J. C. Tarleton, K. W. Rao, C. E. Schwartz, R. Richie, M. B. Tennison, and A. S. Aylsworth. “Fragile X phenotype in a patient with a large de novo deletion in Xq27-q28.” Am J Med Genet 51, no. 4 (July 15, 1994): 294–97. https://doi.org/10.1002/ajmg.1320510403.
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    • Lachiewicz, A. M., and D. V. Dawson. “Behavior problems of young girls with fragile X syndrome: factor scores on the Conners' Parent's Questionnaire.” Am J Med Genet 51, no. 4 (July 15, 1994): 364–69. https://doi.org/10.1002/ajmg.1320510413.
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    • LACHIEWICZ, A. M., and D. V. DAWSON. “DO YOUNG BOYS WITH FRAGILE-X-SYNDROME HAVE MACROORCHIDISM.” Pediatrics 93, no. 6 (June 1, 1994): 992–95.
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    • Lachiewicz, A. M., and D. V. Dawson. “Do young boys with fragile X syndrome have macroorchidism?” Pediatrics 93, no. 6 Pt 1 (June 1994): 992–95.
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    • Lachiewicz, A. M., G. A. Spiridigliozzi, C. M. Gullion, S. N. Ransford, and K. Rao. “Aberrant behaviors of young boys with fragile X syndrome.” Am J Ment Retard 98, no. 5 (March 1994): 567–79.
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    • Lachiewicz, A. M., and D. V. Dawson. “Do young boys with fragile X syndrome have macroorchidism?” Pediatrics 93, no. 6 I (January 1, 1994): 992–95.
    • Tarleton, J., R. Richie, C. Schwartz, K. Rao, A. S. Aylsworth, and A. Lachiewicz. “An extensive de novo deletion removing FMR1 in a patient with mental retardation and the fragile X syndrome phenotype.” Hum Mol Genet 2, no. 11 (November 1993): 1973–74. https://doi.org/10.1093/hmg/2.11.1973.
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    • McConkie-Rosell, A., A. M. Lachiewicz, G. A. Spiridigliozzi, J. Tarleton, S. Schoenwald, M. C. Phelan, P. Goonewardena, X. Ding, and W. T. Brown. “Evidence that methylation of the FMR-I locus is responsible for variable phenotypic expression of the fragile X syndrome.” Am J Hum Genet 53, no. 4 (October 1993): 800–809.
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    • Lachiewicz, A. M. “Abnormal behaviors of young girls with fragile X syndrome.” Am J Med Genet 43, no. 1–2 (April 15, 1992): 72–77. https://doi.org/10.1002/ajmg.1320430111.
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    • Reiss, A. L., C. Cianchetti, I. L. Cohen, B. DeVries, R. Hagerman, V. Hinton, U. Froster, A. Lachiewicz, M. Mazzocco, and W. Sobesky. “Brief screening questionnaire for determining affected state in fragile X syndrome: a consensus recommendation.” Am J Med Genet 43, no. 1–2 (April 15, 1992): 61–64. https://doi.org/10.1002/ajmg.1320430109.
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    • Lachiewicz, A. M., S. F. Hoegerman, G. Holmgren, E. Holmberg, and K. Arinbjarnarson. “Association of the Robin sequence with the fragile X syndrome.” Am J Med Genet 41, no. 3 (December 1, 1991): 275–78. https://doi.org/10.1002/ajmg.1320410302.
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    • Cameron, T. H., A. M. Lachiewicz, and A. S. Aylsworth. “Townes-Brocks syndrome in two mentally retarded youngsters.” Am J Med Genet 41, no. 1 (October 1, 1991): 1–4. https://doi.org/10.1002/ajmg.1320410102.
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    • Hodapp, R. M., E. M. Dykens, R. J. Hagerman, R. Schreiner, A. M. Lachiewicz, and J. F. Leckman. “Developmental implications of changing trajectories of IQ in males with fragile X syndrome.” J Am Acad Child Adolesc Psychiatry 29, no. 2 (March 1990): 214–19. https://doi.org/10.1097/00004583-199003000-00009.
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    • LACHIEWICZ, A. M. “FRAGILE-X SYNDROME - A HANDBOOK FOR FAMILIES AND EDUCATORS - FINUCANE,B.” Journal of Autism and Developmental Disorders 19, no. 4 (December 1, 1989): 643–643.
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    • Lachiewicz, A., C. Harrison, G. A. Spiridigliozzi, N. P. Callanan, and J. Livermore. “What is the fragile X syndrome?” N C Med J 49, no. 4 (April 1988): 203–8.
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    • Lachiewicz, A. M., C. M. Gullion, G. A. Spiridigliozzi, and A. S. Aylsworth. “Declining IQs of young males with the fragile X syndrome.” Am J Ment Retard 92, no. 3 (November 1987): 272–78.
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    • Lachiewicz, A. M., C. M. Gullion, G. A. Spiridigliozzi, and A. S. Alysworth. “Decline in IQ Scores of Young Fragile X Males.” Journal of Developmental & Behavioral Pediatrics 7, no. 3 (June 1986): 201–201. https://doi.org/10.1097/00004703-198606000-00020.
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    • Lachiewicz, A. M., R. Sibley, and A. F. Michael. “Hereditary renal disease and preauricular pits: report of a kindred.” J Pediatr 106, no. 6 (June 1985): 948–50. https://doi.org/10.1016/s0022-3476(85)80248-1.
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    • Lachiewicz, A. M., S. J. Kogan, S. B. Levitt, and R. L. Weiner. “Concurrent agenesis of the corpus callosum and ureteroceles in siblings.” Pediatrics 75, no. 5 (May 1985): 904–7.
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  • Conference Papers

    • DAWSON, D. V., and A. M. LACHIEWICZ. “BEHAVIORAL EPIDEMIOLOGY OF FRAGILE-X SYNDROME IN FEMALE PEDIATRIC POPULATIONS.” In American Journal of Epidemiology, 141:S50–S50. AMER J EPIDEMIOLOGY, 1995.
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    • LACHIEWICZ, A. M., and D. V. DAWSON. “AUTISTIC BEHAVIORS OF YOUNG GIRLS WITH FRAGILE X-SYNDROME.” In Pediatric Research, 35:A23–A23. WILLIAMS & WILKINS, 1994.
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    • LACHIEWICZ, A. M. “PHYSICAL CHARACTERISTICS OF YOUNG BOYS WITH FRAGILE-X SYNDROME.” In 1992 International Fragile X Conference Proceedings, edited by R. J. Hagerman and P. McKenzie, 29–36. SPECTRA PUBLISHING CO INC, 1992.
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    • LACHIEWICZ, A. M., G. A. SPIRIDIGLIOZZI, C. A. GULLION, and S. K. RANSFORD. “ABERRANT BEHAVIORS OF YOUNG BOYS WITH FRAGILE X-SYNDROME.” In Pediatric Research, 27:A12–A12. WILLIAMS & WILKINS, 1990.
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• Scholarly, Clinical, & Service Activities
• 

  Clinical Activities

  • Clinical activities involve working with children who have fragile X syndrome, ADHD, and autism.

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