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Dorsal hippocampal alpha7 and alpha4beta2 nicotinic receptors and memory.

Publication ,  Journal Article
Nott, A; Levin, ED
Published in: Brain Res
April 7, 2006

Nicotinic receptor systems have been shown to be important for working memory. In general, nicotinic agonists have been shown to improve memory, and nicotinic antagonists impair it. All of the neuronal substrates for nicotinic involvement in memory still remain to be discovered. The amygdala and ventral hippocampus have both been found to be important for nicotinic involvement in memory function. Local infusion of the nicotinic antagonist methyllycaconitine (MLA) to block alpha7 nicotinic receptors and dihydro-beta-erythrodine (DHbetaE) to block alpha4beta2 nicotinic receptors into the basolateral amygdala and the ventral hippocampus have been found to impair working memory function, with no additive effects being observed. The current project assessed the roles of alpha7 and alpha4beta2 nicotinic receptors in the dorsal hippocampus for memory function. Adult female Sprague-Dawley rats were trained on the 16-arm radial maze. The rats (n = 10) had bilateral cannulae implanted into the dorsal hippocampus. The rats were given acute infusions of DHbetaE (0, 1.69, 3.38, and 6.75 microg/side) and MLA (6.75 microg/side) alone and in combination in a repeated measures counter-balanced design. DHbetaE and MLA infusion into the dorsal hippocampus significantly increased working memory errors. However, when the two drugs were given in combination, an attenuated effect was seen. No significant effects of MLA or DHbetaE were seen with reference memory errors or response latency. These results confirm the importance of alpha4beta2 and alpha7 nicotinic acetylcholine receptors in the dorsal hippocampus for appetitively-motivated spatial cognitive function.

Duke Scholars

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

April 7, 2006

Volume

1081

Issue

1

Start / End Page

72 / 78

Location

Netherlands

Related Subject Headings

  • alpha7 Nicotinic Acetylcholine Receptor
  • Time Factors
  • Receptors, Nicotinic
  • Reaction Time
  • Rats, Sprague-Dawley
  • Rats
  • Nicotinic Antagonists
  • Neurology & Neurosurgery
  • Memory
  • Maze Learning
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Nott, A., & Levin, E. D. (2006). Dorsal hippocampal alpha7 and alpha4beta2 nicotinic receptors and memory. Brain Res, 1081(1), 72–78. https://doi.org/10.1016/j.brainres.2006.01.052
Nott, Alexi, and Edward D. Levin. “Dorsal hippocampal alpha7 and alpha4beta2 nicotinic receptors and memory.Brain Res 1081, no. 1 (April 7, 2006): 72–78. https://doi.org/10.1016/j.brainres.2006.01.052.
Nott A, Levin ED. Dorsal hippocampal alpha7 and alpha4beta2 nicotinic receptors and memory. Brain Res. 2006 Apr 7;1081(1):72–8.
Nott, Alexi, and Edward D. Levin. “Dorsal hippocampal alpha7 and alpha4beta2 nicotinic receptors and memory.Brain Res, vol. 1081, no. 1, Apr. 2006, pp. 72–78. Pubmed, doi:10.1016/j.brainres.2006.01.052.
Nott A, Levin ED. Dorsal hippocampal alpha7 and alpha4beta2 nicotinic receptors and memory. Brain Res. 2006 Apr 7;1081(1):72–78.
Journal cover image

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

April 7, 2006

Volume

1081

Issue

1

Start / End Page

72 / 78

Location

Netherlands

Related Subject Headings

  • alpha7 Nicotinic Acetylcholine Receptor
  • Time Factors
  • Receptors, Nicotinic
  • Reaction Time
  • Rats, Sprague-Dawley
  • Rats
  • Nicotinic Antagonists
  • Neurology & Neurosurgery
  • Memory
  • Maze Learning