Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1.
Publication
, Journal Article
Kamb, A; Futreal, PA; Rosenthal, J; Cochran, C; Harshman, KD; Liu, Q; Phelps, RS; Tavtigian, SV; Tran, T; Hussey, C
Published in: Genomics
September 1, 1994
The VH1-related human protein (VHR) gene was localized to human chromosome 17q21 in a region thought to contain the BRCA1 locus, a locus that confers susceptibility to breast and ovarian cancer. VHR encodes a phosphatase with dual specificity for tyrosine and serine residues. Thus it is a plausible candidate for a tumor suppressor gene such as BRCA1. To test this possibility, the VHR coding sequence was screened in individuals with familial breast cancer and in sporadic breast tumor and breast cancer cell lines. No mutations were detected, suggesting that the VHR gene is not BRCA1.
Duke Scholars
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Published In
Genomics
DOI
ISSN
0888-7543
Publication Date
September 1, 1994
Volume
23
Issue
1
Start / End Page
163 / 167
Location
United States
Related Subject Headings
- Tumor Cells, Cultured
- Transcription Factors
- RNA, Neoplasm
- RNA, Messenger
- Protein Tyrosine Phosphatases
- Polymorphism, Single-Stranded Conformational
- Polymorphism, Genetic
- Polymerase Chain Reaction
- Neoplasm Proteins
- Molecular Sequence Data
Citation
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Kamb, A., Futreal, P. A., Rosenthal, J., Cochran, C., Harshman, K. D., Liu, Q., … Hussey, C. (1994). Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1. Genomics, 23(1), 163–167. https://doi.org/10.1006/geno.1994.1473
Kamb, A., P. A. Futreal, J. Rosenthal, C. Cochran, K. D. Harshman, Q. Liu, R. S. Phelps, S. V. Tavtigian, T. Tran, and C. Hussey. “Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1.” Genomics 23, no. 1 (September 1, 1994): 163–67. https://doi.org/10.1006/geno.1994.1473.
Kamb A, Futreal PA, Rosenthal J, Cochran C, Harshman KD, Liu Q, et al. Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1. Genomics. 1994 Sep 1;23(1):163–7.
Kamb, A., et al. “Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1.” Genomics, vol. 23, no. 1, Sept. 1994, pp. 163–67. Pubmed, doi:10.1006/geno.1994.1473.
Kamb A, Futreal PA, Rosenthal J, Cochran C, Harshman KD, Liu Q, Phelps RS, Tavtigian SV, Tran T, Hussey C. Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1. Genomics. 1994 Sep 1;23(1):163–167.
Published In
Genomics
DOI
ISSN
0888-7543
Publication Date
September 1, 1994
Volume
23
Issue
1
Start / End Page
163 / 167
Location
United States
Related Subject Headings
- Tumor Cells, Cultured
- Transcription Factors
- RNA, Neoplasm
- RNA, Messenger
- Protein Tyrosine Phosphatases
- Polymorphism, Single-Stranded Conformational
- Polymorphism, Genetic
- Polymerase Chain Reaction
- Neoplasm Proteins
- Molecular Sequence Data