Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1.

Journal Article (Journal Article)

The VH1-related human protein (VHR) gene was localized to human chromosome 17q21 in a region thought to contain the BRCA1 locus, a locus that confers susceptibility to breast and ovarian cancer. VHR encodes a phosphatase with dual specificity for tyrosine and serine residues. Thus it is a plausible candidate for a tumor suppressor gene such as BRCA1. To test this possibility, the VHR coding sequence was screened in individuals with familial breast cancer and in sporadic breast tumor and breast cancer cell lines. No mutations were detected, suggesting that the VHR gene is not BRCA1.

Full Text

Duke Authors

Cited Authors

  • Kamb, A; Futreal, PA; Rosenthal, J; Cochran, C; Harshman, KD; Liu, Q; Phelps, RS; Tavtigian, SV; Tran, T; Hussey, C

Published Date

  • September 1, 1994

Published In

Volume / Issue

  • 23 / 1

Start / End Page

  • 163 - 167

PubMed ID

  • 7829067

International Standard Serial Number (ISSN)

  • 0888-7543

Digital Object Identifier (DOI)

  • 10.1006/geno.1994.1473


  • eng

Conference Location

  • United States