Determinants of disease in the simian immunodeficiency virus-infected rhesus macaque: characterizing animals with low antibody responses and rapid progression.


Journal Article

Clinical and laboratory markers of simian immunodeficiency virus (SIV) infection were studied during the first 3 months after intravenous inoculation of rhesus macaques. Virus-binding serum antibody titres were correlated strongly with disease progression (P < 0.005) and were predictive of disease outcome by 7 weeks after inoculation. Low virus-binding serum antibody responses to SIV occurred in animals that also showed acute depletion of circulating CD20+ B cells. Acute damage to the CD4+ T cell and CD20+ B cell populations rendered some animals incapable of mounting virus-specific antibody responses and these macaques became the rapidly progressing cases comprising approximately 20-30% of infected animal cohorts.

Full Text

Duke Authors

Cited Authors

  • Dykhuizen, M; Mitchen, JL; Montefiori, DC; Thomson, J; Acker, L; Lardy, H; Pauza, CD

Published Date

  • October 1998

Published In

Volume / Issue

  • 79 ( Pt 10) /

Start / End Page

  • 2461 - 2467

PubMed ID

  • 9780052

Pubmed Central ID

  • 9780052

International Standard Serial Number (ISSN)

  • 0022-1317

Digital Object Identifier (DOI)

  • 10.1099/0022-1317-79-10-2461


  • eng

Conference Location

  • England