Thalamic relay of spontaneous retinal activity prior to vision.

Published

Journal Article

Before vision, retinal ganglion cells produce spontaneous waves of action potentials. A crucial question is whether this spontaneous activity is transmitted to lateral geniculate nucleus (LGN) neurons. Using a novel in vitro preparation, we report that LGN neurons receive periodic barrages of postsynaptic currents from the retina that drive them to fire bursts of action potentials. Groups of LGN neurons are highly correlated in their firing. Experiments in wild-type and NMDAR1 knockout mice show that NMDA receptor activation is not necessary for firing. The transmission of the highly correlated retinal activity to the LGN supports the hypothesis that retinal waves drive retinogeniculate synaptic remodeling. Because LGN neurons are driven to fire action potentials, this spontaneous activity could also act more centrally to influence synaptic modification within the developing visual cortex.

Full Text

Duke Authors

Cited Authors

  • Mooney, R; Penn, AA; Gallego, R; Shatz, CJ

Published Date

  • November 1996

Published In

Volume / Issue

  • 17 / 5

Start / End Page

  • 863 - 874

PubMed ID

  • 8938119

Pubmed Central ID

  • 8938119

International Standard Serial Number (ISSN)

  • 0896-6273

Language

  • eng

Conference Location

  • United States