Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors.
Publication
, Journal Article
Nie, Z; Schweitzer, P; Roberts, AJ; Madamba, SG; Moore, SD; Siggins, GR
Published in: Science
March 5, 2004
The central amygdala (CeA) plays a role in the relationship among stress, corticotropin-releasing factor (CRF), and alcohol abuse. In whole-cell recordings, both CRF and ethanol enhanced gamma-aminobutyric acid-mediated (GABAergic) neurotransmission in CeA neurons from wild-type and CRF2 receptor knockout mice, but not CRF1 receptor knockout mice. CRF1 (but not CRF2) receptor antagonists blocked both CRF and ethanol effects in wild-type mice. These data indicate that CRF1 receptors mediate ethanol enhancement of GABAergic synaptic transmission in the CeA, and they suggest a cellular mechanism underlying involvement of CRF in ethanol's behavioral and motivational effects.
Duke Scholars
Published In
Science
DOI
EISSN
1095-9203
Publication Date
March 5, 2004
Volume
303
Issue
5663
Start / End Page
1512 / 1514
Location
United States
Related Subject Headings
- gamma-Aminobutyric Acid
- Synaptic Transmission
- Stress, Psychological
- Receptors, GABA-A
- Receptors, Corticotropin-Releasing Hormone
- Patch-Clamp Techniques
- Neurons
- Mice, Knockout
- Mice, Inbred C57BL
- Mice
Citation
APA
Chicago
ICMJE
MLA
NLM
Nie, Z., Schweitzer, P., Roberts, A. J., Madamba, S. G., Moore, S. D., & Siggins, G. R. (2004). Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors. Science, 303(5663), 1512–1514. https://doi.org/10.1126/science.1092550
Nie, Zhiguo, Paul Schweitzer, Amanda J. Roberts, Samuel G. Madamba, Scott D. Moore, and George Robert Siggins. “Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors.” Science 303, no. 5663 (March 5, 2004): 1512–14. https://doi.org/10.1126/science.1092550.
Nie Z, Schweitzer P, Roberts AJ, Madamba SG, Moore SD, Siggins GR. Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors. Science. 2004 Mar 5;303(5663):1512–4.
Nie, Zhiguo, et al. “Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors.” Science, vol. 303, no. 5663, Mar. 2004, pp. 1512–14. Pubmed, doi:10.1126/science.1092550.
Nie Z, Schweitzer P, Roberts AJ, Madamba SG, Moore SD, Siggins GR. Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors. Science. 2004 Mar 5;303(5663):1512–1514.
Published In
Science
DOI
EISSN
1095-9203
Publication Date
March 5, 2004
Volume
303
Issue
5663
Start / End Page
1512 / 1514
Location
United States
Related Subject Headings
- gamma-Aminobutyric Acid
- Synaptic Transmission
- Stress, Psychological
- Receptors, GABA-A
- Receptors, Corticotropin-Releasing Hormone
- Patch-Clamp Techniques
- Neurons
- Mice, Knockout
- Mice, Inbred C57BL
- Mice