Overview
We are currently developing a model system for the investigation of physiological effects of acute ethanol. This model utilizes a rat brain slice preparation incorporating the amygdala, a brain region associated with anxiety and ethanol-induced anxiolysis. We anticipate expanding this model to investigate effects of other anxiolytic agents and to elucidate the basic mechanisms underlying anxiogenesis.
We are also currently examining the neurobiological basis of seizure-induced memory disruption using similar in vitro electrophysiological techniques. Full development of this model should provide important information relevant to basic mechanisms of memory. We anticipate expanding this model to include behavioral correlates.
We are also currently examining the neurobiological basis of seizure-induced memory disruption using similar in vitro electrophysiological techniques. Full development of this model should provide important information relevant to basic mechanisms of memory. We anticipate expanding this model to include behavioral correlates.
Current Appointments & Affiliations
Professor Emeritus of Psychiatry and Behavioral Sciences
·
2024 - Present
Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology,
Psychiatry & Behavioral Sciences
Faculty Network Member of the Duke Institute for Brain Sciences
·
2008 - Present
Duke Institute for Brain Sciences,
University Institutes and Centers
Recent Publications
Black Americans With Sickle Cell Disease (SCD) Demonstrate Accelerated Epigenetic Pace of Aging Compared to Black Americans Without SCD.
Journal Article J Gerontol A Biol Sci Med Sci · November 1, 2024 BACKGROUND: Sickle cell disease (SCD) is a chronic medical condition characterized by red blood cell sickling, vaso-occlusion, hemolytic anemia, and subsequently, end-organ damage and reduced survival. Because of this significant pathophysiology and early ... Full text Link to item CiteGeorge Robert Siggins: Researcher, musician, surfer, mentor, and friend.
Journal Article Alcohol Clin Exp Res (Hoboken) · September 2024 Full text Link to item CitePosttraumatic stress disorder, trauma, and accelerated biological aging among post-9/11 veterans.
Journal Article Transl Psychiatry · January 6, 2024 People who experience trauma and develop posttraumatic stress disorder (PTSD) are at increased risk for poor health. One mechanism that could explain this risk is accelerated biological aging, which is associated with the accumulation of chronic diseases, ... Full text Open Access Link to item CiteRecent Grants
Cost Effectiveness of Combined Contingency Management and Cognitive Behavioral Therapy for Alcohol Use Disorder
ResearchCo Investigator · Awarded by National Institutes of Health · 2019 - 2025Mobile Contingency Management for Concurrent Abstinence from Alcohol and Smoking
ResearchCo Investigator · Awarded by National Institutes of Health · 2017 - 2021IPA - Qiang Li
ResearchPrincipal Investigator · Awarded by Durham Veterans Affairs Medical Center · 2018 - 2020View All Grants
Education, Training & Certifications
University of Virginia ·
1986
M.D.
University of Virginia ·
1986
Ph.D.
University of Virginia ·
1986
M.D.