Somatostatin augments the M-current in hippocampal neurons.


Journal Article

Immunocytochemical and electrophysiological evidence suggests that somatostatin may be a transmitter in the hippocampus. To characterize the ionic mechanisms underlying somatostatin effects, voltage-clamp and current-clamp studies on single CA1 pyramidal neurons in the hippocampal slice preparation were performed. Both somatostatin-28 and somatostatin-14 elicited a steady outward current and selectively augmented the noninactivating, voltage-dependent outward potassium current known as the M-current. Since the muscarinic cholinergic agonists carbachol and muscarine antagonized this current, these results suggest a reciprocal regulation of the M-current by somatostatin and acetylcholine.

Full Text

Duke Authors

Cited Authors

  • Moore, SD; Madamba, SG; Joëls, M; Siggins, GR

Published Date

  • January 15, 1988

Published In

Volume / Issue

  • 239 / 4837

Start / End Page

  • 278 - 280

PubMed ID

  • 2892268

Pubmed Central ID

  • 2892268

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.2892268


  • eng

Conference Location

  • United States