Enkephalin analogues depress synaptic potentials in rat dentate granule cells recorded intracellularly in vitro.

Journal Article (Journal Article)

Enkephalin analogues were superfused onto hippocampal slices during intracellular recording of dentate granule cells. The enkephalins elicited either weak depolarizations, weak hyperpolarizations, or no effect on membrane potential, in about equal numbers of cells tested. Similarly, input resistance either decreased, increased or did not change, and was not well correlated with the potential changes. However, at all concentrations tested (2-10 microM) the enkephalins reduced evoked depolarizing synaptic potentials by up to 70%. We speculate that a major function of endogenous enkephalin-containing fibers projecting to the dentate is to dampen afferent synaptic transmission.

Full Text

Duke Authors

Cited Authors

  • Moore, SD; Madamba, SG; Zieglgänsberger, W; Siggins, GR

Published Date

  • August 15, 1988

Published In

Volume / Issue

  • 91 / 1

Start / End Page

  • 71 - 76

PubMed ID

  • 3050621

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/0304-3940(88)90251-0


  • eng

Conference Location

  • Ireland