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A mechanism of COOH-terminal binding protein-mediated repression.

Publication ,  Journal Article
Meloni, AR; Lai, C-H; Yao, T-P; Nevins, JR
Published in: Mol Cancer Res
October 2005

The E2F4 and E2F5 proteins specifically associate with the Rb-related p130 protein in quiescent cells to repress transcription of various genes encoding proteins important for cell growth. A series of reports has provided evidence that Rb-mediated repression involves both histone deacetylase (HDAC)-dependent and HDAC-independent events. Our previous results suggest that one such mechanism for Rb-mediated repression, independent of recruitment of HDAC, involves the recruitment of the COOH-terminal binding protein (CtBP) corepressor, a protein now recognized to play a widespread role in transcriptional repression. We now find that CtBP can interact with the histone acetyltransferase, cyclic AMP--responsive element--binding protein (CREB) binding protein, and inhibit its ability to acetylate histone. This inhibition is dependent on a NH2-terminal region of CtBP that is also required for transcription repression. These results thus suggest two complementary mechanisms for E2F/p130-mediated repression that have in common the control of histone acetylation at target promoters.

Duke Scholars

Published In

Mol Cancer Res

DOI

ISSN

1541-7786

Publication Date

October 2005

Volume

3

Issue

10

Start / End Page

575 / 583

Location

United States

Related Subject Headings

  • Transfection
  • Transcription, Genetic
  • Transcription Factors
  • Repressor Proteins
  • Phosphoproteins
  • Oncology & Carcinogenesis
  • Humans
  • Histone Deacetylases
  • E2F Transcription Factors
  • Developmental Biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Meloni, A. R., Lai, C.-H., Yao, T.-P., & Nevins, J. R. (2005). A mechanism of COOH-terminal binding protein-mediated repression. Mol Cancer Res, 3(10), 575–583. https://doi.org/10.1158/1541-7786.MCR-05-0088
Meloni, Alison R., Chun-Hsiang Lai, Tso-Pang Yao, and Joseph R. Nevins. “A mechanism of COOH-terminal binding protein-mediated repression.Mol Cancer Res 3, no. 10 (October 2005): 575–83. https://doi.org/10.1158/1541-7786.MCR-05-0088.
Meloni AR, Lai C-H, Yao T-P, Nevins JR. A mechanism of COOH-terminal binding protein-mediated repression. Mol Cancer Res. 2005 Oct;3(10):575–83.
Meloni, Alison R., et al. “A mechanism of COOH-terminal binding protein-mediated repression.Mol Cancer Res, vol. 3, no. 10, Oct. 2005, pp. 575–83. Pubmed, doi:10.1158/1541-7786.MCR-05-0088.
Meloni AR, Lai C-H, Yao T-P, Nevins JR. A mechanism of COOH-terminal binding protein-mediated repression. Mol Cancer Res. 2005 Oct;3(10):575–583.

Published In

Mol Cancer Res

DOI

ISSN

1541-7786

Publication Date

October 2005

Volume

3

Issue

10

Start / End Page

575 / 583

Location

United States

Related Subject Headings

  • Transfection
  • Transcription, Genetic
  • Transcription Factors
  • Repressor Proteins
  • Phosphoproteins
  • Oncology & Carcinogenesis
  • Humans
  • Histone Deacetylases
  • E2F Transcription Factors
  • Developmental Biology