High-side digitally current controlled biphasic bipolar microstimulator.

Journal Article (Journal Article)

Electrical stimulation of nervous tissue has been extensively used as both a tool in experimental neuroscience research and as a method for restoring of neural functions in patients suffering from sensory and motor disabilities. In the central nervous system, intracortical microstimulation (ICMS) has been shown to be an effective method for inducing or biasing perception, including visual and tactile sensation. ICMS also holds promise for enabling brain-machine-brain interfaces (BMBIs) by directly writing information into the brain. Here we detail the design of a high-side, digitally current-controlled biphasic, bipolar microstimulator, and describe the validation of the device in vivo. As many applications of this technique, including BMBIs, require recording as well as stimulation, we pay careful attention to isolation of the stimulus channels and parasitic current injection. With the realized device and standard recording hardware-without active artifact rejection-we are able to observe stimulus artifacts of less than 2 ms in duration.

Full Text

Duke Authors

Cited Authors

  • Hanson, TL; Ómarsson, B; O'Doherty, JE; Peikon, ID; Lebedev, MA; Nicolelis, MAL

Published Date

  • May 2012

Published In

Volume / Issue

  • 20 / 3

Start / End Page

  • 331 - 340

PubMed ID

  • 22328184

Pubmed Central ID

  • PMC3502026

Electronic International Standard Serial Number (EISSN)

  • 1558-0210

Digital Object Identifier (DOI)

  • 10.1109/TNSRE.2012.2187219


  • eng

Conference Location

  • United States