The insular cortex controls food preferences independently of taste receptor signaling.

Published online

Journal Article

The insular cortex (IC) contains the primary sensory cortex for oral chemosensation including gustation, and its integrity is required for appropriate control of feeding behavior. However, it remains unknown whether the role of this brain area in food selection relies on the presence of peripheral taste input. Using multielectrode recordings, we found that the responses of populations of neurons in the IC of freely licking, sweet-blind Trpm5(-/-) mice are modulated by the rewarding postingestive effects of sucrose. FOS immunoreactivity analyses revealed that these responses are restricted to the dorsal insula. Furthermore, bilateral lesions in this area abolished taste-independent preferences for sucrose that can be conditioned in these Trpm5(-/-) animals while preserving their ability to detect sucrose. Overall, these findings demonstrate that, even in the absence of peripheral taste input, IC regulates food choices based on postingestive signals.

Full Text

Duke Authors

Cited Authors

  • Oliveira-Maia, AJ; de Araujo, IE; Monteiro, C; Workman, V; Galhardo, V; Nicolelis, MAL

Published Date

  • 2012

Published In

Volume / Issue

  • 6 /

Start / End Page

  • 5 -

PubMed ID

  • 22403530

Pubmed Central ID

  • 22403530

Electronic International Standard Serial Number (EISSN)

  • 1662-5137

Digital Object Identifier (DOI)

  • 10.3389/fnsys.2012.00005

Language

  • eng

Conference Location

  • Switzerland