ASH evidence-based guidelines: is the IgG-specific anti-PF4/heparin ELISA superior to the polyspecific ELISA in the laboratory diagnosis of HIT?
Journal Article (Journal Article;Review)
You are asked to consult on a 76-year-old man admitted to the hospital with pneumonia and thrombocytopenia. Ten days before the current admission, he had undergone surgery to repair a small bowel obstruction. A preoperative platelet count had been normal. Following surgery, he received subcutaneous unfractionated heparin thromboprophylaxis until his discharge on post-operative day 5. In your differential diagnosis for the patient's thrombocytopenia, you consider heparin-induced thrombocytopenia (HIT) and wish to order laboratory testing. In addition to a polyspecific anti-PF4/heparin ELISA for the diagnosis of HIT, your laboratory has recently begun to offer an IgG-specific ELISA. You wonder which of these assays performs better in the diagnosis of HIT.
Full Text
Duke Authors
Cited Authors
- Cuker, A; Ortel, TL
Published Date
- 2009
Published In
Start / End Page
- 250 - 252
PubMed ID
- 20008206
Electronic International Standard Serial Number (EISSN)
- 1520-4383
Digital Object Identifier (DOI)
- 10.1182/asheducation-2009.1.250
Language
- eng
Conference Location
- United States