ASH evidence-based guidelines: is the IgG-specific anti-PF4/heparin ELISA superior to the polyspecific ELISA in the laboratory diagnosis of HIT?

Journal Article (Journal Article;Review)

You are asked to consult on a 76-year-old man admitted to the hospital with pneumonia and thrombocytopenia. Ten days before the current admission, he had undergone surgery to repair a small bowel obstruction. A preoperative platelet count had been normal. Following surgery, he received subcutaneous unfractionated heparin thromboprophylaxis until his discharge on post-operative day 5. In your differential diagnosis for the patient's thrombocytopenia, you consider heparin-induced thrombocytopenia (HIT) and wish to order laboratory testing. In addition to a polyspecific anti-PF4/heparin ELISA for the diagnosis of HIT, your laboratory has recently begun to offer an IgG-specific ELISA. You wonder which of these assays performs better in the diagnosis of HIT.

Full Text

Duke Authors

Cited Authors

  • Cuker, A; Ortel, TL

Published Date

  • 2009

Published In

Start / End Page

  • 250 - 252

PubMed ID

  • 20008206

Electronic International Standard Serial Number (EISSN)

  • 1520-4383

Digital Object Identifier (DOI)

  • 10.1182/asheducation-2009.1.250


  • eng

Conference Location

  • United States