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ASH evidence-based guidelines: is the IgG-specific anti-PF4/heparin ELISA superior to the polyspecific ELISA in the laboratory diagnosis of HIT?

Publication ,  Journal Article
Cuker, A; Ortel, TL
Published in: Hematology Am Soc Hematol Educ Program
2009

You are asked to consult on a 76-year-old man admitted to the hospital with pneumonia and thrombocytopenia. Ten days before the current admission, he had undergone surgery to repair a small bowel obstruction. A preoperative platelet count had been normal. Following surgery, he received subcutaneous unfractionated heparin thromboprophylaxis until his discharge on post-operative day 5. In your differential diagnosis for the patient's thrombocytopenia, you consider heparin-induced thrombocytopenia (HIT) and wish to order laboratory testing. In addition to a polyspecific anti-PF4/heparin ELISA for the diagnosis of HIT, your laboratory has recently begun to offer an IgG-specific ELISA. You wonder which of these assays performs better in the diagnosis of HIT.

Duke Scholars

Published In

Hematology Am Soc Hematol Educ Program

DOI

EISSN

1520-4383

Publication Date

2009

Start / End Page

250 / 252

Location

United States

Related Subject Headings

  • Thrombocytopenia
  • Sensitivity and Specificity
  • Practice Guidelines as Topic
  • Postoperative Complications
  • Platelet Factor 4
  • Male
  • Intestinal Obstruction
  • Immunoglobulin G
  • Humans
  • Heparin
 

Citation

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Chicago
ICMJE
MLA
NLM
Cuker, A., & Ortel, T. L. (2009). ASH evidence-based guidelines: is the IgG-specific anti-PF4/heparin ELISA superior to the polyspecific ELISA in the laboratory diagnosis of HIT? Hematology Am Soc Hematol Educ Program, 250–252. https://doi.org/10.1182/asheducation-2009.1.250
Cuker, Adam, and Thomas L. Ortel. “ASH evidence-based guidelines: is the IgG-specific anti-PF4/heparin ELISA superior to the polyspecific ELISA in the laboratory diagnosis of HIT?Hematology Am Soc Hematol Educ Program, 2009, 250–52. https://doi.org/10.1182/asheducation-2009.1.250.
Cuker, Adam, and Thomas L. Ortel. “ASH evidence-based guidelines: is the IgG-specific anti-PF4/heparin ELISA superior to the polyspecific ELISA in the laboratory diagnosis of HIT?Hematology Am Soc Hematol Educ Program, 2009, pp. 250–52. Pubmed, doi:10.1182/asheducation-2009.1.250.

Published In

Hematology Am Soc Hematol Educ Program

DOI

EISSN

1520-4383

Publication Date

2009

Start / End Page

250 / 252

Location

United States

Related Subject Headings

  • Thrombocytopenia
  • Sensitivity and Specificity
  • Practice Guidelines as Topic
  • Postoperative Complications
  • Platelet Factor 4
  • Male
  • Intestinal Obstruction
  • Immunoglobulin G
  • Humans
  • Heparin