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Response of hypertrophied myocardium to ischemia: correlation with biochemical and physiological parameters.

Publication ,  Journal Article
Sink, JD; Pellom, GL; Currie, WD; Hill, RC; Olsen, CO; Jones, RN; Wechsler, AS
Published in: J Thorac Cardiovasc Surg
June 1981

The increased susceptibility of hypertrophied hearts to ischemic injury during cardiac operations has long been recognized. Although the imbalances in oxygen supply and demand which may occur with hypertrophy during hypotension, ventricular fibrillation, or reperfusion have been extensively studied, the biochemical response of hypertrophied myocardium to ischemia has not been fully elucidated. In the present investigation, rat hearts in which hypertrophy was induced by chronic pressure overload were used to examine the relationship of the physiological parameter, ischemic contracture, to high-energy phosphate content and mitochondrial function during global ischemia. Hypertrophied hearts developed ischemic contracture after significantly shorter duration of ischemia than did normal hearts (5.8 +/- 0.3 minutes versus 10.1 +/- 0.7 minutes). High-energy phosphate content was lower in hypertrophied hearts at control and at ischemic contracture initiation and completion than in normal hearts, whereas mitochondrial function was consistently greater in the hypertrophy group. This investigation demonstrates that the hypertrophied myocardium, independent of flow-related events, is more vulnerable to ischemic injury than normal myocardium and suggests that the increased susceptibility may result from lower high-energy phosphate stores present at the onset of ischemia. The results emphasize the need for rapid cardiac arrest with the induction of ischemia in hypertrophied myocardium and suggest the potential for increasing myocardial high-energy phosphate content in the hypertrophied ventricle by interventions such as arrested perfusion with substrate containing oxygenated cardioplegic solutions prior to the onset of planned ischemia.

Duke Scholars

Published In

J Thorac Cardiovasc Surg

ISSN

0022-5223

Publication Date

June 1981

Volume

81

Issue

6

Start / End Page

865 / 872

Location

United States

Related Subject Headings

  • Respiratory System
  • Rats
  • Phosphates
  • Organ Size
  • Myocardium
  • Myocardial Contraction
  • Male
  • Heart Ventricles
  • Heart Arrest, Induced
  • Cardiomegaly
 

Citation

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Sink, J. D., Pellom, G. L., Currie, W. D., Hill, R. C., Olsen, C. O., Jones, R. N., & Wechsler, A. S. (1981). Response of hypertrophied myocardium to ischemia: correlation with biochemical and physiological parameters. J Thorac Cardiovasc Surg, 81(6), 865–872.
Sink, J. D., G. L. Pellom, W. D. Currie, R. C. Hill, C. O. Olsen, R. N. Jones, and A. S. Wechsler. “Response of hypertrophied myocardium to ischemia: correlation with biochemical and physiological parameters.J Thorac Cardiovasc Surg 81, no. 6 (June 1981): 865–72.
Sink JD, Pellom GL, Currie WD, Hill RC, Olsen CO, Jones RN, et al. Response of hypertrophied myocardium to ischemia: correlation with biochemical and physiological parameters. J Thorac Cardiovasc Surg. 1981 Jun;81(6):865–72.
Sink, J. D., et al. “Response of hypertrophied myocardium to ischemia: correlation with biochemical and physiological parameters.J Thorac Cardiovasc Surg, vol. 81, no. 6, June 1981, pp. 865–72.
Sink JD, Pellom GL, Currie WD, Hill RC, Olsen CO, Jones RN, Wechsler AS. Response of hypertrophied myocardium to ischemia: correlation with biochemical and physiological parameters. J Thorac Cardiovasc Surg. 1981 Jun;81(6):865–872.
Journal cover image

Published In

J Thorac Cardiovasc Surg

ISSN

0022-5223

Publication Date

June 1981

Volume

81

Issue

6

Start / End Page

865 / 872

Location

United States

Related Subject Headings

  • Respiratory System
  • Rats
  • Phosphates
  • Organ Size
  • Myocardium
  • Myocardial Contraction
  • Male
  • Heart Ventricles
  • Heart Arrest, Induced
  • Cardiomegaly