Systems biology of vaccination for seasonal influenza in humans.
Journal Article (Journal Article)
Here we have used a systems biology approach to study innate and adaptive responses to vaccination against influenza in humans during three consecutive influenza seasons. We studied healthy adults vaccinated with trivalent inactivated influenza vaccine (TIV) or live attenuated influenza vaccine (LAIV). TIV induced higher antibody titers and more plasmablasts than LAIV did. In subjects vaccinated with TIV, early molecular signatures correlated with and could be used to accurately predict later antibody titers in two independent trials. Notably, expression of the kinase CaMKIV at day 3 was inversely correlated with later antibody titers. Vaccination of CaMKIV-deficient mice with TIV induced enhanced antigen-specific antibody titers, which demonstrated an unappreciated role for CaMKIV in the regulation of antibody responses. Thus, systems approaches can be used to predict immunogenicity and provide new mechanistic insights about vaccines.
Full Text
Duke Authors
Cited Authors
- Nakaya, HI; Wrammert, J; Lee, EK; Racioppi, L; Marie-Kunze, S; Haining, WN; Means, AR; Kasturi, SP; Khan, N; Li, G-M; McCausland, M; Kanchan, V; Kokko, KE; Li, S; Elbein, R; Mehta, AK; Aderem, A; Subbarao, K; Ahmed, R; Pulendran, B
Published Date
- July 10, 2011
Published In
Volume / Issue
- 12 / 8
Start / End Page
- 786 - 795
PubMed ID
- 21743478
Pubmed Central ID
- PMC3140559
Electronic International Standard Serial Number (EISSN)
- 1529-2916
Digital Object Identifier (DOI)
- 10.1038/ni.2067
Language
- eng
Conference Location
- United States