Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., University of Naples Federico II (Italy) 1985
  • Ph.D., University of Naples Federico II (Italy) 1982
• 

  Duke Appointment History

  • Visiting Professor in the Department of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2006
• Research
• 

  Selected Grants

  • Cancer cell intrinsic and extrinsic actions of steroid hormones in breast tumors awarded by Department of Defense 2018 - 2022
  • Mitigating the gastrointestinal acute radiation syndrome by blocking calcium/calmodulin-dependent protein kinase kinase 2 awarded by Department of Defense 2019 - 2020
  • Development of CaMKK2 inhibitor drug for acute radiation syndrome awarded by Columbia University 2018 - 2019
  • Identify chemical probes for CAMKK2 to target the tumor microenvironment and enhance anti-tumor immune response awarded by University of North Carolina - Chapel Hill 2017 - 2019
  • Macrophages and Treatment-Resistant NVAMD awarded by National Institutes of Health 2015 - 2019
  • Determining the mechanism of the protective of action of STO-609, a CaMKK2 inhibitor, in acute radiation syndrome awarded by Columbia University 2016 - 2018
  • CaMKK2: a druggable target that regulates macrophage function in breast cancer awarded by Susan G. Komen Breast Cancer Foundation 2013 - 2017
  • A novel therapeutic target for radiation-induced hematological malignancies: calcium calmodulin kinase kinase 2 awarded by Department of Defense 2015 - 2017
  • CaM Kinase Cascades in Endocrine Cells awarded by National Institutes of Health 1997 - 2011
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Racioppi, Luigi, William Lento, Wei Huang, Stephanie Arvai, Phuong L. Doan, Jeffrey R. Harris, Fernando Marcon, Helder I. Nakaya, Yaping Liu, and Nelson Chao. “Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration..” Cell Death Dis 8, no. 10 (October 5, 2017). https://doi.org/10.1038/cddis.2017.474.
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    • Vitiello, Laura, Elisabetta Ferraro, Salvatore De Simone, Lucia Gatta, Alessandra Feraco, Luigi Racioppi, and Giuseppe Rosano. “CXCL12 prolongs naive CD4+ T lymphocytes survival via activation of PKA, CREB and Bcl2 and BclXl up-regulation..” International Journal of Cardiology 224 (December 2016): 206–12. https://doi.org/10.1016/j.ijcard.2016.09.007.
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    • Lento, William, Takahiro Ito, Chen Zhao, Jeffrey R. Harris, Wei Huang, Chen Jiang, Kouros Owzar, et al. “Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration..” Genes & Development 28, no. 9 (May 2014): 995–1004. https://doi.org/10.1101/gad.231944.113.
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    • Cary, Rachel L., Seid Waddell, Luigi Racioppi, Fanxin Long, Deborah V. Novack, Michael J. Voor, and Uma Sankar. “Inhibition of Ca²⁺/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation..” Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research 28, no. 7 (July 2013): 1599–1610. https://doi.org/10.1002/jbmr.1890.
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    • Racioppi, Luigi. “CaMKK2: a novel target for shaping the androgen-regulated tumor ecosystem..” Trends in Molecular Medicine 19, no. 2 (February 2013): 83–88. https://doi.org/10.1016/j.molmed.2012.12.004.
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    • Roach, Jeffrey M., Luigi Racioppi, Corbin D. Jones, and Anna Maria Masci. “Phylogeny of Toll-like receptor signaling: adapting the innate response..” Plos One 8, no. 1 (January 11, 2013). https://doi.org/10.1371/journal.pone.0054156.
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    • Racioppi, Luigi, and Anthony R. Means. “Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology..” J Biol Chem 287, no. 38 (September 14, 2012): 31658–65. https://doi.org/10.1074/jbc.R112.356485.
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    • Racioppi, Luigi, Pamela K. Noeldner, Fumin Lin, Stephanie Arvai, and Anthony R. Means. “Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses..” J Biol Chem 287, no. 14 (March 30, 2012): 11579–91. https://doi.org/10.1074/jbc.M111.336032.
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    • Barberi, Theresa J., Alexis Dunkle, You-Wen He, Luigi Racioppi, and Anthony R. Means. “The prolyl isomerase Pin1 modulates development of CD8+ cDC in mice..” Plos One 7, no. 1 (January 4, 2012). https://doi.org/10.1371/journal.pone.0029808.
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    • Teng, Ellen C., Luigi Racioppi, and Anthony R. Means. “A cell-intrinsic role for CaMKK2 in granulocyte lineage commitment and differentiation..” Journal of Leukocyte Biology 90, no. 5 (November 2011): 897–909. https://doi.org/10.1189/jlb.0311152.
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    • Cancrini, Caterina, Alessia Scarselli, Samantha Scaramuzza, Maria Chiriaco, Silvia Di Cesare, Gigliola Di Matteo, Maria Luisa Romiti, et al. “Early-onset monocyte-B-natural killer-dendritic cells' deficiency successfully treated with hematopoietic stem cell transplantation..” The Journal of Allergy and Clinical Immunology 128, no. 4 (October 2011): 897-900.e1. https://doi.org/10.1016/j.jaci.2011.07.044.
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    • Nakaya, Helder I., Jens Wrammert, Eva K. Lee, Luigi Racioppi, Stephanie Marie-Kunze, W Nicholas Haining, Anthony R. Means, et al. “Systems biology of vaccination for seasonal influenza in humans..” Nat Immunol 12, no. 8 (July 10, 2011): 786–95. https://doi.org/10.1038/ni.2067.
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    • Vigliano, I., M. Gorrese, A. Fusco, L. Vitiello, S. Amorosi, L. Panico, M. V. Ursini, et al. “FOXN1 mutation abrogates prenatal T-cell development in humans..” Journal of Medical Genetics 48, no. 6 (June 2011): 413–16. https://doi.org/10.1136/jmg.2011.089532.
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    • Vigliano, I., M. Gorrese, A. Fusco, L. Vitiello, S. Amorosi, L. Panico, M. V. Ursini, et al. “FOXN1 mutation abrogates prenatal T-cell development in humans.” Journal of Medical Genetics, April 19, 2011. https://doi.org/10.1136/jmg.2011.089532.
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    • Giardino Torchia, Maria Letizia, Elena Ciaglia, Anna Maria Masci, Laura Vitiello, Manuela Fogli, Andrea la Sala, Domenico Mavilio, and Luigi Racioppi. “Dendritic cells/natural killer cross-talk: a novel target for human immunodeficiency virus type-1 protease inhibitors..” Plos One 5, no. 6 (January 2010). https://doi.org/10.1371/journal.pone.0011052.
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    • Torchia, M. L. G., E. Ciaglia, A. M. Masci, L. Vitiello, M. Fogli, A. L. Sala, D. Mavilio, and L. Racioppi. “Dendritic cells/natural killer cross-talk: A novel target for human immunodeficiency virus type-1 protease inhibitors.” Plos One 5, no. 6 (2010). https://doi.org/10.1371/journal.pone.0011052.
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    • Vitiello, L., A. M. Masci, L. Montella, F. Perna, D. F. Angelini, G. Borsellino, L. Battistini, et al. “Thymoma-associated immunodeficiency: a syndrome characterized by severe alterations in NK, T and B-cells and progressive increase in naïve CD8+ T Cells..” International Journal of Immunopathology and Pharmacology 23, no. 1 (January 2010): 307–16. https://doi.org/10.1177/039463201002300129.
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    • Damiano, Vincenzo, Sonia Garofalo, Roberta Rosa, Roberto Bianco, Rosa Caputo, Teresa Gelardi, Gerardina Merola, et al. “A novel toll-like receptor 9 agonist cooperates with trastuzumab in trastuzumab-resistant breast tumors through multiple mechanisms of action..” Clinical Cancer Research : An Official Journal of the American Association for Cancer Research 15, no. 22 (November 10, 2009): 6921–30. https://doi.org/10.1158/1078-0432.ccr-09-1599.
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    • Racioppi, Luigi, and Anthony R. Means. “Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller..” Trends in Immunology 29, no. 12 (December 2008): 600–607. https://doi.org/10.1016/j.it.2008.08.005.
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    • Perrella, Alessandro, Laura Vitiello, Luigi Atripaldi, Costanza Sbreglia, Stella Grattacaso, Pasquale Bellopede, Tommaso Patarino, et al. “Impaired function of CD4+/CD25+ T regulatory lymphocytes characterizes the self-limited hepatitis A virus infection..” Journal of Gastroenterology and Hepatology 23, no. 7 Pt 2 (July 2008): e105–10. https://doi.org/10.1111/j.1440-1746.2007.05008.x.
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    • Illario, Maddalena, Maria L. Giardino-Torchia, Uma Sankar, Thomas J. Ribar, Mario Galgani, Laura Vitiello, Anna Maria Masci, et al. “Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells..” Blood 111, no. 2 (January 2008): 723–31. https://doi.org/10.1182/blood-2007-05-091173.
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    • Damiano, Vincenzo, Rosa Caputo, Sonia Garofalo, Roberto Bianco, Roberta Rosa, Gerardina Merola, Teresa Gelardi, et al. “TLR9 agonist acts by different mechanisms synergizing with bevacizumab in sensitive and cetuximab-resistant colon cancer xenografts..” Proceedings of the National Academy of Sciences of the United States of America 104, no. 30 (July 16, 2007): 12468–73. https://doi.org/10.1073/pnas.0705226104.
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    • Laurentiis, G. de, L. Vitiello, L. Racioppi, F. Perna, M. Galgani, G. Merola, P. Carratù, M. Maniscalco, S. Marsico, and M. Sofia. “CD8+ T-cell alveolitis in familial pulmonary alveolar microlithiasis..” The European Respiratory Journal 30, no. 1 (July 2007): 165–71. https://doi.org/10.1183/09031936.00145406.
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    • Lambiase, Alessandro, Eduardo Maria Normando, Laura Vitiello, Alessandra Micera, Marta Sacchetti, Eleonora Perrella, Luigi Racioppi, Sergio Bonini, and Stefano Bonini. “Natural killer cells in vernal keratoconjunctivitis..” Molecular Vision 13 (January 2007): 1562–67.
    • Palmieri, Giovannella, Carmine Selleri, Liliana Montella, Goffredo Bulgarelli, Laura Vitiello, Ghassan Merkabaoui, Patrizia Ricci, et al. “Thymoma followed by paroxysmal nocturnal hemoglobinuria: a unique clinical association in the context of multiorgan autoimmunity with a potential role for CD8+ T lymphocytes..” American Journal of Hematology 81, no. 10 (October 2006): 774–78. https://doi.org/10.1002/ajh.20699.
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    • Perrella, A., L. Vitiello, L. Atripaldi, P. Conti, C. Sbreglia, S. Altamura, T. Patarino, et al. “Elevated CD4+/CD25+ T cell frequency and function during acute hepatitis C presage chronic evolution..” Gut 55, no. 9 (September 2006): 1370–71. https://doi.org/10.1136/gut.2006.099887.
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    • Scottà, Cristiano, Loretta Tuosto, Anna Maria Masci, Luigi Racioppi, Enza Piccolella, and Loredana Frasca. “Hypervariable region 1 variant acting as TCR antagonist affects hepatitis C virus-specific CD4+ T cell repertoire by favoring CD95-mediated apoptosis..” Journal of Leukocyte Biology 78, no. 2 (August 2005): 372–82. https://doi.org/10.1189/jlb.0804456.
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    • Montella, Liliana, Ghassam Merkabaoui, Laura Vitiello, Goffredo Bulgarelli, Gianfranco Sinagra, Anna Maria Masci, Luigi Racioppi, and Giovannella Palmieri. “Fatal immunodeficiency in a patient with thymoma and Good's syndrome..” Tumori 91, no. 4 (July 2005): 361–63.
    • Auricchio, Luigi, Laura Vitiello, Marsilio Adriani, Pasqualina Ferri, Annalisa Chiocchetti, Guido Pettinato, Luigi Racioppi, Luigi Maiuri, Umberto Dianzani, and Claudio Pignata. “Cutaneous manifestations as presenting sign of autoimmune lymphoproliferative syndrome in childhood..” Dermatology (Basel, Switzerland) 210, no. 4 (January 2005): 336–40. https://doi.org/10.1159/000084762.
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    • Ruggiero, Giuseppina, Giuseppe Terrazzano, Cristina Becchimanzi, Michela Sica, Claudia Andretta, Anna Maria Masci, Luigi Racioppi, Bruno Rotoli, Serafino Zappacosta, and Fiorella Alfinito. “GPI-defective monocytes from paroxysmal nocturnal hemoglobinuria patients show impaired in vitro dendritic cell differentiation..” Journal of Leukocyte Biology 76, no. 3 (September 2004): 634–40. https://doi.org/10.1189/jlb.1203607.
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    • Zur Stadt, Udo, Karin Beutel, Belinda Weber, Hartmut Kabisch, Reinhard Schneppenheim, and Gritta Janka. “A91V is a polymorphism in the perforin gene not causative of an FHLH phenotype..” Blood 104, no. 6 (September 2004). https://doi.org/10.1182/blood-2004-02-0733.
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    • Galgani, Mario, Immacolata Busiello, Stefano Censini, Serafino Zappacosta, Luigi Racioppi, and Raffaele Zarrilli. “Helicobacter pylori induces apoptosis of human monocytes but not monocyte-derived dendritic cells: role of the cag pathogenicity island..” Infection and Immunity 72, no. 8 (August 2004): 4480–85. https://doi.org/10.1128/IAI.72.8.4480-4485.2004.
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    • Galgani, Mario, Veronica De Rosa, Salvatore De Simone, Antonio Leonardi, Ugo D’Oro, Giorgio Napolitani, Anna Maria Masci, Serafino Zappacosta, and Luigi Racioppi. “Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling..” The Journal of Biological Chemistry 279, no. 31 (July 2004): 32507–14. https://doi.org/10.1074/jbc.m403355200.
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    • Busiello, Rosanna, Marsilio Adriani, Franco Locatelli, Mario Galgani, Giorgia Fimiani, Rita Clementi, Matilde Valeria Ursini, Luigi Racioppi, and Claudio Pignata. “Atypical features of familial hemophagocytic lymphohistiocytosis..” Blood 103, no. 12 (June 2004): 4610–12. https://doi.org/10.1182/blood-2003-10-3551.
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    • Masci, Anna Maria, Mario Galgani, Silvana Cassano, Salvatore De Simone, Adriana Gallo, Veronica De Rosa, Serafino Zappacosta, and Luigi Racioppi. “HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling..” Journal of Leukocyte Biology 74, no. 6 (December 2003): 1117–24. https://doi.org/10.1189/jlb.0503239.
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    • Napolitani, Giorgio, Nicola Bortoletto, Luigi Racioppi, Antonio Lanzavecchia, and Ugo D’Oro. “Activation of src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation..” European Journal of Immunology 33, no. 10 (October 2003): 2832–41. https://doi.org/10.1002/eji.200324073.
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    • Frasca, Loredana, Cristiano Scottà, Paola Del Porto, Alfredo Nicosia, Caterina Pasquazzi, Ilaria Versace, Anna Maria Masci, Luigi Racioppi, and Enza Piccolella. “Antibody-selected mimics of hepatitis C virus hypervariable region 1 activate both primary and memory Th lymphocytes..” Hepatology (Baltimore, Md.) 38, no. 3 (September 2003): 653–63. https://doi.org/10.1053/jhep.2003.50387.
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    • Montella, L., A. M. Masci, G. Merkabaoui, F. Perna, L. Vitiello, L. Racioppi, and G. Palmieri. “B-cell lymphopenia and hypogammaglobulinemia in thymoma patients..” Annals of Hematology 82, no. 6 (June 2003): 343–47. https://doi.org/10.1007/s00277-003-0635-z.
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    • Masci, Anna Maria, Giovannella Palmieri, Laura Vitiello, Liliana Montella, Francesco Perna, Paola Orlandi, Gianfranco Abbate, Serafino Zappacosta, Raffaele De Palma, and Luigi Racioppi. “Clonal expansion of CD8+ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia..” Blood 101, no. 8 (April 2003): 3106–8. https://doi.org/10.1182/blood-2002-08-2638.
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    • Matarese, G., G. Castelli-Gattinara, C. Cancrini, S. Bernardi, M. L. Romiti, C. Savarese, A. Di Giacomo, P. Rossi, and L. Racioppi. “Serum leptin and CD4+ T lymphocytes in HIV+ children during highly active antiretroviral therapy..” Clinical Endocrinology 57, no. 5 (November 2002): 643–46. https://doi.org/10.1046/j.1365-2265.2002.01634.x.
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    • Cancrini, C., M. L. Romiti, S. Di Cesare, F. Angelini, D. Gigliotti, S. Livadiotti, E. Bertini, P. Rossi, and L. Racioppi. “Restriction in T-cell receptor repertoire in a patient affected by trichothiodystrophy and CD4+ lymphopenia..” Scandinavian Journal of Immunology 56, no. 2 (August 2002): 212–16. https://doi.org/10.1046/j.1365-3083.2002.01122.x.
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    • Buonaguro, L., L. Racioppi, M. L. Tornesello, C. Arra, M. L. Visciano, B. Biryahwaho, S. D. Sempala, G. Giraldo, and F. M. Buonaguro. “Induction of neutralizing antibodies and cytotoxic T lymphocytes in Balb/c mice immunized with virus-like particles presenting a gp120 molecule from a HIV-1 isolate of clade A..” Antiviral Research 54, no. 3 (June 2002): 189–201. https://doi.org/10.1016/s0166-3542(02)00004-9.
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    • Racioppi, L., C. Cancrini, M. L. Romiti, F. Angelini, S. Di Cesare, E. Bertini, S. Livadiotti, et al. “Defective dendritic cell maturation in a child with nucleotide excision repair deficiency and CD4 lymphopenia..” Clinical and Experimental Immunology 126, no. 3 (December 2001): 511–18. https://doi.org/10.1046/j.1365-2249.2001.01625.x.
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    • Lago Paz, F., M. Galgani, U. D’Oro, G. Matarese, A. M. Masci, S. Zappacosta, and L. Racioppi. “Modulation of CD45 tyrosine phosphatase activity by antigen..” European Journal of Immunology 31, no. 3 (March 2001): 777–82. https://doi.org/10.1002/1521-4141(200103)31:3<777::aid-immu777gt;3.0.co;2-i.
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    • Montanaro, D., V. Sanna, G. Matarese, B. B. Larby, L. Racioppi, P. B. Carrieri, R. Bruno, N. J. Davey, S. Zappacosta, and S. Fontana. “The fine specificity of human T cell lines towards myelin basic protein peptides in southern Italian multiple sclerosis patients..” Clinical and Experimental Immunology 123, no. 2 (February 2001): 288–93. https://doi.org/10.1046/j.1365-2249.2001.01457.x.
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    • Pignata, C., L. Gaetaniello, A. M. Masci, J. Frank, A. Christiano, E. Matrecano, and L. Racioppi. “Human equivalent of the mouse Nude/SCID phenotype: long-term evaluation of immunologic reconstitution after bone marrow transplantation..” Blood 97, no. 4 (February 2001): 880–85. https://doi.org/10.1182/blood.v97.4.880.
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    • Biasin, M., S. L. Caputo, L. Speciale, F. Colombo, L. Racioppi, A. Zagliani, C. Blé, et al. “Mucosal and systemic immune activation is present in human immunodeficiency virus-exposed seronegative women..” The Journal of Infectious Diseases 182, no. 5 (November 2000): 1365–74. https://doi.org/10.1086/315873.
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    • Ragione, F. D., V. Cucciolla, A. Borriello, V. D. Pietra, G. Pontoni, L. Racioppi, C. Manna, P. Galletti, and V. Zappia. “Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis..” Biochemical and Biophysical Research Communications 278, no. 3 (November 2000): 733–39. https://doi.org/10.1006/bbrc.2000.3875.
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    • Del Giudice, E., L. Gaetaniello, E. Matrecano, E. Cosentini, M. V. Ursini, L. Racioppi, G. Arrigo, and C. Pignata. “Brain migration disorder and T-cell activation deficiency associated with abnormal signaling through TCR/CD3 complex and hyperactivity of Fyn tyrosine kinase..” Neuropediatrics 31, no. 5 (October 2000): 265–68. https://doi.org/10.1055/s-2000-9234.
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    • Masci, A. M., G. Palmieri, F. Perna, L. Montella, G. Merkabaoui, G. Sacerdoti, A. Martignetti, and L. Racioppi. “Immunological findings in thymoma and thymoma-related syndromes..” Annals of Medicine 31 Suppl 2 (October 1999): 86–89.
    • Masci, A. M., F. L. Paz, A. Borriello, S. Cassano, V. Della Pietra, H. Stoiber, G. Matarese, F. Della Ragione, S. Zappacosta, and L. Racioppi. “Effects of human immunodeficiency virus type 1 on CD4 lymphocyte subset activation..” European Journal of Immunology 29, no. 6 (June 1999): 1879–89. https://doi.org/10.1002/(sici)1521-4141(199906)29:06&amp;#60;1879::aid-immu1879&amp;#62;3.0.co;2-2.
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    • De Placido, G., C. Alviggi, G. Di Palma, C. Carravetta, G. Matarese, G. Landino, and L. Racioppi. “Serum concentrations of soluble human leukocyte class I antigens and of the soluble intercellular adhesion molecule-1 in endometriosis: relationship with stage and non-pigmented peritoneal lesions..” Human Reproduction (Oxford, England) 13, no. 11 (November 1998): 3206–10. https://doi.org/10.1093/humrep/13.11.3206.
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    • Ragione, F. D., V. Cucciolla, A. Borriello, V. D. Pietra, L. Racioppi, G. Soldati, C. Manna, P. Galletti, and V. Zappia. “Resveratrol arrests the cell division cycle at S/G2 phase transition..” Biochemical and Biophysical Research Communications 250, no. 1 (September 1998): 53–58. https://doi.org/10.1006/bbrc.1998.9263.
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    • POZZI, N. “Combined signal transduction abnormalities through TCR and growth hormone (GH) receptors in 2 unrelated patients.” Molecular Immunology 35, no. 11–12 (August 1998): 716–716. https://doi.org/10.1016/s0161-5890(98)90374-1.
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    • Scotese, I., L. Gaetaniello, G. Matarese, M. Lecora, L. Racioppi, and C. Pignata. “T cell activation deficiency associated with an aberrant pattern of protein tyrosine phosphorylation after CD3 perturbation in Down's syndrome..” Pediatric Research 44, no. 2 (August 1998): 252–58. https://doi.org/10.1203/00006450-199808000-00019.
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    • Racioppi, L., G. Matarese, U. D’Oro, M. De Pascale, A. M. Masci, S. Fontana, and S. Zappacosta. “The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling..” Proc Natl Acad Sci U S A 93, no. 19 (September 17, 1996): 10360–65. https://doi.org/10.1073/pnas.93.19.10360.
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    • Jeso, B. di, L. Ulianich, L. Racioppi, F. D’Armiento, A. Feliciello, F. Pacifico, E. Consiglio, and S. Formisano. “Serum withdrawal induces apoptotic cell death in Ki-ras transformed but not in normal differentiated thyroid cells..” Biochemical and Biophysical Research Communications 214, no. 3 (September 1995): 819–24. https://doi.org/10.1006/bbrc.1995.2360.
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    • Masci, A. M., S. Scala, L. Racioppi, and S. Zappacosta. “Cell surface expression of major histocompatibility class I antigens is modulated by P-glycoprotein transporter..” Human Immunology 42, no. 3 (March 1995): 245–53. https://doi.org/10.1016/0198-8859(94)00096-9.
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    • Racioppi, L., and R. N. Germain. “Modified T-cell receptor ligands: moving beyond a strict occupancy model for T-cell activation by antigen..” Chemical Immunology 60 (January 1995): 79–99.
    • Boehncke, W. H., T. Takeshita, C. D. Pendleton, R. A. Houghten, S. Sadegh-Nasseri, L. Racioppi, J. A. Berzofsky, and R. N. Germain. “The Importance of Dominant Negative Effects of Amino Acid Side Chain Substitution in Peptide-MHC Molecule Interactions and T Cell Recognition.” Journal of Immunology 150, no. 2 (December 1, 1993).
    • Di Rosa, F., U. D’Oro, G. Ruggiero, L. Racioppi, A. Acquaviva, S. Ferrone, S. Fontana, and S. Zappacosta. “HLA class II molecules transduce accessory signals affecting the CD3 but not the interleukin-2 activation pathway in T blasts..” Human Immunology 38, no. 4 (December 1993): 251–60. https://doi.org/10.1016/0198-8859(93)90552-c.
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    • Racioppi, L., F. Ronchese, L. A. Matis, and R. N. Germain. “Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling..” The Journal of Experimental Medicine 177, no. 4 (April 1993): 1047–60. https://doi.org/10.1084/jem.177.4.1047.
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    • Boehncke, W. H., T. Takeshita, C. D. Pendleton, R. A. Houghten, S. Sadegh-Nasseri, L. Racioppi, J. A. Berzofsky, and R. N. Germain. “The importance of dominant negative effects of amino acid side chain substitution in peptide-MHC molecule interactions and T cell recognition..” Journal of Immunology (Baltimore, Md. : 1950) 150, no. 2 (January 1993): 331–41.
    • RACIOPPI, L. “Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling.” J Exp Med 177 (1993): 1047–60. https://doi.org/10.1084/jem.177.4.1047.
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    • Racioppi, L., F. Ronchese, R. H. Schwartz, and R. N. Germain. “The molecular basis of class II MHC allelic control of T cell responses..” Journal of Immunology (Baltimore, Md. : 1950) 147, no. 11 (December 1991): 3718–27.
    • Carbone, E., L. Racioppi, A. La Cava, G. Portella, F. Velotti, S. Zappacosta, and S. Fontana. “NK and LAK susceptibility varies inversely with target cell MHC class I antigen expression in a rat epithelial tumour system..” Scandinavian Journal of Immunology 33, no. 2 (February 1991): 185–94. https://doi.org/10.1111/j.1365-3083.1991.tb03748.x.
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    • Ruggiero, G., L. Racioppi, C. Manzo, G. Pirozzi, U. D’Oro, S. Ferrone, S. Zappacosta, and S. Fontana. “HLA class II molecules on monocytes regulate T cell proliferation through physical interaction in the CD3 activation pathway..” European Journal of Immunology 21, no. 1 (January 1991): 29–33. https://doi.org/10.1002/eji.1830210106.
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    • Racioppi, L., A. Moscarella, G. Ruggiero, C. Manzo, S. Ferrone, S. Fontana, and S. Zappacosta. “Inhibition by anti-HLA class II monoclonal antibodies of monoclonal antibody OKT3-induced T cell proliferation. Studies at the mRNA level..” Journal of Immunology (Baltimore, Md. : 1950) 145, no. 11 (December 1990): 3635–40.
    • Manzo, C., G. Ruggiero, L. del Vecchio, L. Racioppi, G. Pirozzi, M. Temponi, S. Ferrone, S. Fontana, and S. Zappacosta. “Monoclonal antibody OKT3-induced T cell proliferation: differential role of HLA class II determinants expressed by T cells and monocytes..” Cellular Immunology 125, no. 1 (January 1990): 79–91. https://doi.org/10.1016/0008-8749(90)90064-x.
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    • Racioppi, L., E. Carbone, M. Grieco, L. Del Vecchio, M. T. Berlingieri, A. Fusco, E. Boncinelli, S. Zappacosta, and S. Fontana. “The relationship of modulation of major histocompatibility complex class I antigens to retrovirus transformation in rat cell lines..” Cancer Research 48, no. 13 (July 1988): 3816–21.
    • Fontana, S., L. Del Vecchio, L. Racioppi, E. Carbone, A. Pinto, G. Colletta, and S. Zappacosta. “Expression of major histocompatibility complex class I antigens in normal and transformed rat thyroid epithelial cell lines..” Cancer Research 47, no. 15 (August 1987): 4178–83.

  • Conference Papers

    • Huang, Wei, Yaping Liu, Nelson J. Chao, and Luigi Racioppi. “Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CaMKK2) Expressed in the Host Promotes Lymphoma Cells Growth By Controlling Myeloid Derived Suppressor Cells Expansion.” In Blood, Vol. 132. AMER SOC HEMATOLOGY, 2018. https://doi.org/10.1182/blood-2018-99-117147.
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    • Vitiello, L., E Elisabetta Ferraro, S. De Simone, G. Rosano, and L. Racioppi. “Exposure to CXCL12 prolonges naive CD4+T lymphocytes survival..” In European Journal of Heart Failure, 18:282–282. WILEY-BLACKWELL, 2016.
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    • Lento, William, Wei Huang, Doan Phuong, Nelson J. Chao, and Luigi Racioppi. “Calcium Calmodulin Dependent Kinase Kinase 2 Regulates Hematopoietic Stem Cell Regeneration and Quiescence.” In Blood, Vol. 124. AMER SOC HEMATOLOGY, 2014.
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    • Racioppi, Luigi, Pamela Noeldner, Fumin Lin, Stephanie Arvai, and Anthony Means. “Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 Regulates Macrophage-Mediated Inflammatory Responses.” In Journal of Immunology, Vol. 188. AMER ASSOC IMMUNOLOGISTS, 2012.
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    • Tortora, Giampaolo, Sonia Garofalo, Rosa Caputo, Roberto Bianco, Roberta Rosa, Teresa Gelardi, Gerardina Merola, et al. “Toll-like receptor 9 (TLR9) interacts with ErbB receptors at membrane level and a TLR9 agonist synergizes with trastuzumab in trastuzumab-resistant breast cancer xenografts via modulation of ErbB signalling.” In Cancer Research, Vol. 69. AMER ASSOC CANCER RESEARCH, 2009.
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    • Perrella, Alessandro, Luigi Racioppi, Luigi Atripaldi, Simona Pisanti, Costanza Sbreglia, Pasquale Bellopede, and Oreste Perrella. “HBV vaccination with evidence of protective antibodies titer induces CD4+/CD25+T cells.” In Gastroenterology, 130:A849–A849. W B SAUNDERS CO-ELSEVIER INC, 2006.
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    • Perrella, Alessandro, Luigi Racioppi, Luigi Atripaldi, Laura Vitiello, Simona Pisanti, Pasquale Bellopede, Tommaso Patarino, Raffaele Vela, Tiziana Ascione, and Oreste Perrella. “Elevated CD4+/CD25+ regulatory T cell frequency and function in acute hepatitis C genotype 1, presage chronic evolution.” In Journal of Gastroenterology and Hepatology, 21:A114–A114. BLACKWELL PUBLISHING, 2006.
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    • Perrella, Alessandro, Luigi Racioppi, Simona Pisanti, Laura Vitiello, Salvatore De Simone, Costanza Sbreglia, Pasquale Bellopede, Tommaso Patarino, Lugi Atripaldi, and Oreste Perrella. “Increase CD4+/CD25+ T cells frequency and function occur after HBV vaccine administration at protective titer.” In Journal of Gastroenterology and Hepatology, 21:A113–14. BLACKWELL PUBLISHING, 2006.
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    • Gaetaniello, L., I. Scotese, G. Matarese, S. deFilippo, L. Racioppi, and C. Pignata. “Abnormal tyrosine phosphorylated 30 kDa protein in a patient with immunodeficiency and severe encephalopathy associated with a constitutive activation of the MAPK cascade..” In Blood, 88:1982–1982. W B SAUNDERS CO, 1996.
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    • RACIOPPI, L., F. RONCHESE, R. SCHWARTZ, and R. GERMAIN. “QUANTITATIVE AND QUALITATIVE EFFECTS OF CLASS-II MHC MOLECULE POLYMORPHISM ON PEPTIDE BINDING.” In Faseb Journal, 5:A724–A724. FEDERATION AMER SOC EXP BIOL, 1991.
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