Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Naples Federico II (Italy) 1992
  • M.D., University of Naples Federico II (Italy) 1985
• 

  Duke Appointment History

  • Associate Professor in Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2020
  • Assistant Professor in Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2011 - 2020
  • Visiting Professor in the Department of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2006
• Research
• 

  Selected Grants

  • CaMKK2 inhibition as an approach to increase tumor immunity in breast cancers awarded by Department of Defense 2020 - 2023
  • CaMKK2 inhibition as an approach to increase tumor immunity in breast cancers awarded by Department of Defense 2020 - 2023
  • Cancer cell intrinsic and extrinsic actions of steroid hormones in breast tumors awarded by Department of Defense 2018 - 2022
  • Mitigating the gastrointestinal acute radiation syndrome by blocking calcium/calmodulin-dependent protein kinase kinase 2 awarded by Department of Defense 2019 - 2020
  • Development of CaMKK2 inhibitor drug for acute radiation syndrome awarded by Columbia University 2018 - 2020
  • Identify chemical probes for CAMKK2 to target the tumor microenvironment and enhance anti-tumor immune response awarded by University of North Carolina - Chapel Hill 2017 - 2020
  • Macrophages and Treatment-Resistant NVAMD awarded by National Institutes of Health 2015 - 2019
  • Determining the mechanism of the protective of action of STO-609, a CaMKK2 inhibitor, in acute radiation syndrome awarded by Columbia University 2016 - 2018
  • CaMKK2: a druggable target that regulates macrophage function in breast cancer awarded by Susan G. Komen Breast Cancer Foundation 2013 - 2017
  • A novel therap[eutic target for radiation-induced hematological malignancies: calcium calmodulin kinase kinase 2 awarded by Department of Defense 2015 - 2017
  • CaM Kinase Cascades in Endocrine Cells awarded by National Institutes of Health 1997 - 2011
• 

  External Relationships

  • UNIVERSITY OF NAPLES FEDERICO II
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Carbone, Ennio, Mario De Felice, Francesca Di Rosa, Ugo D’Oro, Silvia Fontana, Antonio La Cava, Michele Maio, et al. “Serafino Zappacosta: An Enlightened Mentor and Educator.” Front Immunol 11 (2020): 217. https://doi.org/10.3389/fimmu.2020.00217.
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    • Racioppi, Luigi, Erik R. Nelson, Wei Huang, Debarati Mukherjee, Scott A. Lawrence, William Lento, Anna Maria Masci, et al. “CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer.” Nat Commun 10, no. 1 (June 4, 2019): 2450. https://doi.org/10.1038/s41467-019-10424-5.
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    • Liu, Yang, Wei Huang, Chuanfeng Xiong, Yuxian Huang, Benny J. Chen, Luigi Racioppi, Nelson Chao, and Tuan Vo-Dinh. “Biodistribution and sensitive tracking of immune cells with plasmonic gold nanostars.” Int J Nanomedicine 14 (2019): 3403–11. https://doi.org/10.2147/IJN.S192189.
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    • Racioppi, Luigi, William Lento, Wei Huang, Stephanie Arvai, Phuong L. Doan, Jeffrey R. Harris, Fernando Marcon, Helder I. Nakaya, Yaping Liu, and Nelson Chao. “Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration.” Cell Death Dis 8, no. 10 (October 5, 2017): e3076. https://doi.org/10.1038/cddis.2017.474.
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    • Vitiello, Laura, Elisabetta Ferraro, Salvatore De Simone, Lucia Gatta, Alessandra Feraco, Luigi Racioppi, and Giuseppe Rosano. “CXCL12 prolongs naive CD4+ T lymphocytes survival via activation of PKA, CREB and Bcl2 and BclXl up-regulation.” Int J Cardiol 224 (December 1, 2016): 206–12. https://doi.org/10.1016/j.ijcard.2016.09.007.
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    • Lento, William, Takahiro Ito, Chen Zhao, Jeffrey R. Harris, Wei Huang, Chen Jiang, Kouros Owzar, et al. “Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration.” Genes Dev 28, no. 9 (May 1, 2014): 995–1004. https://doi.org/10.1101/gad.231944.113.
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    • Cary, Rachel L., Seid Waddell, Luigi Racioppi, Fanxin Long, Deborah V. Novack, Michael J. Voor, and Uma Sankar. “Inhibition of Ca²⁺/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation.” J Bone Miner Res 28, no. 7 (July 2013): 1599–1610. https://doi.org/10.1002/jbmr.1890.
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    • Racioppi, Luigi. “CaMKK2: a novel target for shaping the androgen-regulated tumor ecosystem.” Trends Mol Med 19, no. 2 (February 2013): 83–88. https://doi.org/10.1016/j.molmed.2012.12.004.
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    • Roach, Jeffrey M., Luigi Racioppi, Corbin D. Jones, and Anna Maria Masci. “Phylogeny of Toll-like receptor signaling: adapting the innate response.” Plos One 8, no. 1 (2013): e54156. https://doi.org/10.1371/journal.pone.0054156.
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    • Racioppi, Luigi, and Anthony R. Means. “Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology.” J Biol Chem 287, no. 38 (September 14, 2012): 31658–65. https://doi.org/10.1074/jbc.R112.356485.
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    • Racioppi, Luigi, Pamela K. Noeldner, Fumin Lin, Stephanie Arvai, and Anthony R. Means. “Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses.” J Biol Chem 287, no. 14 (March 30, 2012): 11579–91. https://doi.org/10.1074/jbc.M111.336032.
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    • Barberi, Theresa J., Alexis Dunkle, You-Wen He, Luigi Racioppi, and Anthony R. Means. “The prolyl isomerase Pin1 modulates development of CD8+ cDC in mice.” Plos One 7, no. 1 (2012): e29808. https://doi.org/10.1371/journal.pone.0029808.
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    • Teng, Ellen C., Luigi Racioppi, and Anthony R. Means. “A cell-intrinsic role for CaMKK2 in granulocyte lineage commitment and differentiation.” J Leukoc Biol 90, no. 5 (November 2011): 897–909. https://doi.org/10.1189/jlb.0311152.
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    • Cancrini, Caterina, Alessia Scarselli, Samantha Scaramuzza, Maria Chiriaco, Silvia Di Cesare, Gigliola Di Matteo, Maria Luisa Romiti, et al. “Early-onset monocyte-B-natural killer-dendritic cells' deficiency successfully treated with hematopoietic stem cell transplantation.” J Allergy Clin Immunol 128, no. 4 (October 2011): 897-900.e1. https://doi.org/10.1016/j.jaci.2011.07.044.
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    • Nakaya, Helder I., Jens Wrammert, Eva K. Lee, Luigi Racioppi, Stephanie Marie-Kunze, W Nicholas Haining, Anthony R. Means, et al. “Systems biology of vaccination for seasonal influenza in humans.” Nat Immunol 12, no. 8 (July 10, 2011): 786–95. https://doi.org/10.1038/ni.2067.
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    • Vigliano, I., M. Gorrese, A. Fusco, L. Vitiello, S. Amorosi, L. Panico, M. V. Ursini, et al. “FOXN1 mutation abrogates prenatal T-cell development in humans.” J Med Genet 48, no. 6 (June 2011): 413–16. https://doi.org/10.1136/jmg.2011.089532.
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    • Giardino Torchia, Maria Letizia, Elena Ciaglia, Anna Maria Masci, Laura Vitiello, Manuela Fogli, Andrea la Sala, Domenico Mavilio, and Luigi Racioppi. “Dendritic cells/natural killer cross-talk: a novel target for human immunodeficiency virus type-1 protease inhibitors.” Plos One 5, no. 6 (June 10, 2010): e11052. https://doi.org/10.1371/journal.pone.0011052.
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    • Torchia, M. L. G., E. Ciaglia, A. M. Masci, L. Vitiello, M. Fogli, A. L. Sala, D. Mavilio, and L. Racioppi. “Dendritic cells/natural killer cross-talk: A novel target for human immunodeficiency virus type-1 protease inhibitors.” Plos One 5, no. 6 (2010). https://doi.org/10.1371/journal.pone.0011052.
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    • Vitiello, L., A. M. Masci, L. Montella, F. Perna, D. F. Angelini, G. Borsellino, L. Battistini, et al. “Thymoma-associated immunodeficiency: a syndrome characterized by severe alterations in NK, T and B-cells and progressive increase in naïve CD8+ T Cells.” Int J Immunopathol Pharmacol 23, no. 1 (January 2010): 307–16. https://doi.org/10.1177/039463201002300129.
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    • Damiano, Vincenzo, Sonia Garofalo, Roberta Rosa, Roberto Bianco, Rosa Caputo, Teresa Gelardi, Gerardina Merola, et al. “A novel toll-like receptor 9 agonist cooperates with trastuzumab in trastuzumab-resistant breast tumors through multiple mechanisms of action.” Clin Cancer Res 15, no. 22 (November 15, 2009): 6921–30. https://doi.org/10.1158/1078-0432.CCR-09-1599.
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    • Racioppi, Luigi, and Anthony R. Means. “Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller.” Trends Immunol 29, no. 12 (December 2008): 600–607. https://doi.org/10.1016/j.it.2008.08.005.
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    • Perrella, Alessandro, Laura Vitiello, Luigi Atripaldi, Costanza Sbreglia, Stella Grattacaso, Pasquale Bellopede, Tommaso Patarino, et al. “Impaired function of CD4+/CD25+ T regulatory lymphocytes characterizes the self-limited hepatitis A virus infection.” J Gastroenterol Hepatol 23, no. 7 Pt 2 (July 2008): e105–10. https://doi.org/10.1111/j.1440-1746.2007.05008.x.
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    • Illario, Maddalena, Maria L. Giardino-Torchia, Uma Sankar, Thomas J. Ribar, Mario Galgani, Laura Vitiello, Anna Maria Masci, et al. “Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells.” Blood 111, no. 2 (January 15, 2008): 723–31. https://doi.org/10.1182/blood-2007-05-091173.
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    • Lambiase, Alessandro, Eduardo Maria Normando, Laura Vitiello, Alessandra Micera, Marta Sacchetti, Eleonora Perrella, Luigi Racioppi, Sergio Bonini, and Stefano Bonini. “Natural killer cells in vernal keratoconjunctivitis.” Mol Vis 13 (August 30, 2007): 1562–67.
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    • Damiano, Vincenzo, Rosa Caputo, Sonia Garofalo, Roberto Bianco, Roberta Rosa, Gerardina Merola, Teresa Gelardi, et al. “TLR9 agonist acts by different mechanisms synergizing with bevacizumab in sensitive and cetuximab-resistant colon cancer xenografts.” Proc Natl Acad Sci U S A 104, no. 30 (July 24, 2007): 12468–73. https://doi.org/10.1073/pnas.0705226104.
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    • Laurentiis, G. de, L. Vitiello, L. Racioppi, F. Perna, M. Galgani, G. Merola, P. Carratù, M. Maniscalco, S. Marsico, and M. Sofia. “CD8+ T-cell alveolitis in familial pulmonary alveolar microlithiasis.” Eur Respir J 30, no. 1 (July 2007): 165–71. https://doi.org/10.1183/09031936.00145406.
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    • Palmieri, Giovannella, Carmine Selleri, Liliana Montella, Goffredo Bulgarelli, Laura Vitiello, Ghassan Merkabaoui, Patrizia Ricci, et al. “Thymoma followed by paroxysmal nocturnal hemoglobinuria: a unique clinical association in the context of multiorgan autoimmunity with a potential role for CD8+ T lymphocytes.” Am J Hematol 81, no. 10 (October 2006): 774–78. https://doi.org/10.1002/ajh.20699.
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    • Perrella, A., L. Vitiello, L. Atripaldi, P. Conti, C. Sbreglia, S. Altamura, T. Patarino, et al. “Elevated CD4+/CD25+ T cell frequency and function during acute hepatitis C presage chronic evolution.” Gut 55, no. 9 (September 2006): 1370–71. https://doi.org/10.1136/gut.2006.099887.
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    • Scottà, Cristiano, Loretta Tuosto, Anna Maria Masci, Luigi Racioppi, Enza Piccolella, and Loredana Frasca. “Hypervariable region 1 variant acting as TCR antagonist affects hepatitis C virus-specific CD4+ T cell repertoire by favoring CD95-mediated apoptosis.” J Leukoc Biol 78, no. 2 (August 2005): 372–82. https://doi.org/10.1189/jlb.0804456.
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    • Montella, Liliana, Ghassam Merkabaoui, Laura Vitiello, Goffredo Bulgarelli, Gianfranco Sinagra, Anna Maria Masci, Luigi Racioppi, and Giovannella Palmieri. “Fatal immunodeficiency in a patient with thymoma and Good's syndrome.” Tumori 91, no. 4 (July 2005): 361–63.
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    • Auricchio, Luigi, Laura Vitiello, Marsilio Adriani, Pasqualina Ferri, Annalisa Chiocchetti, Guido Pettinato, Luigi Racioppi, Luigi Maiuri, Umberto Dianzani, and Claudio Pignata. “Cutaneous manifestations as presenting sign of autoimmune lymphoproliferative syndrome in childhood.” Dermatology 210, no. 4 (2005): 336–40. https://doi.org/10.1159/000084762.
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    • Busiello, R., M. Galgani, C. De Fusco, V. Poggi, M. Adriani, L. Racioppi, and C. Pignata. “Role of A91V mutation in perforin gene in hemophagocytic lymphohistiocytosis.” Blood 104, no. 6 (September 15, 2004): 1910–1910.
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    • Zur Stadt, Udo, Karin Beutel, Belinda Weber, Hartmut Kabisch, Reinhard Schneppenheim, and Gritta Janka. “A91V is a polymorphism in the perforin gene not causative of an FHLH phenotype.” Blood 104, no. 6 (September 15, 2004): 1909. https://doi.org/10.1182/blood-2004-02-0733.
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    • Ruggiero, Giuseppina, Giuseppe Terrazzano, Cristina Becchimanzi, Michela Sica, Claudia Andretta, Anna Maria Masci, Luigi Racioppi, Bruno Rotoli, Serafino Zappacosta, and Fiorella Alfinito. “GPI-defective monocytes from paroxysmal nocturnal hemoglobinuria patients show impaired in vitro dendritic cell differentiation.” J Leukoc Biol 76, no. 3 (September 2004): 634–40. https://doi.org/10.1189/jlb.1203607.
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    • Galgani, Mario, Immacolata Busiello, Stefano Censini, Serafino Zappacosta, Luigi Racioppi, and Raffaele Zarrilli. “Helicobacter pylori induces apoptosis of human monocytes but not monocyte-derived dendritic cells: role of the cag pathogenicity island.” Infect Immun 72, no. 8 (August 2004): 4480–85. https://doi.org/10.1128/IAI.72.8.4480-4485.2004.
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    • Galgani, Mario, Veronica De Rosa, Salvatore De Simone, Antonio Leonardi, Ugo D’Oro, Giorgio Napolitani, Anna Maria Masci, Serafino Zappacosta, and Luigi Racioppi. “Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling.” J Biol Chem 279, no. 31 (July 30, 2004): 32507–14. https://doi.org/10.1074/jbc.M403355200.
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    • Busiello, Rosanna, Marsilio Adriani, Franco Locatelli, Mario Galgani, Giorgia Fimiani, Rita Clementi, Matilde Valeria Ursini, Luigi Racioppi, and Claudio Pignata. “Atypical features of familial hemophagocytic lymphohistiocytosis.” Blood 103, no. 12 (June 15, 2004): 4610–12. https://doi.org/10.1182/blood-2003-10-3551.
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    • Masci, Anna Maria, Mario Galgani, Silvana Cassano, Salvatore De Simone, Adriana Gallo, Veronica De Rosa, Serafino Zappacosta, and Luigi Racioppi. “HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling.” J Leukoc Biol 74, no. 6 (December 2003): 1117–24. https://doi.org/10.1189/jlb.0503239.
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    • Napolitani, Giorgio, Nicola Bortoletto, Luigi Racioppi, Antonio Lanzavecchia, and Ugo D’Oro. “Activation of src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation.” Eur J Immunol 33, no. 10 (October 2003): 2832–41. https://doi.org/10.1002/eji.200324073.
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    • Frasca, Loredana, Cristiano Scottà, Paola Del Porto, Alfredo Nicosia, Caterina Pasquazzi, Ilaria Versace, Anna Maria Masci, Luigi Racioppi, and Enza Piccolella. “Antibody-selected mimics of hepatitis C virus hypervariable region 1 activate both primary and memory Th lymphocytes.” Hepatology 38, no. 3 (September 2003): 653–63. https://doi.org/10.1053/jhep.2003.50387.
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    • Montella, L., A. M. Masci, G. Merkabaoui, F. Perna, L. Vitiello, L. Racioppi, and G. Palmieri. “B-cell lymphopenia and hypogammaglobulinemia in thymoma patients.” Ann Hematol 82, no. 6 (June 2003): 343–47. https://doi.org/10.1007/s00277-003-0635-z.
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    • Masci, Anna Maria, Giovannella Palmieri, Laura Vitiello, Liliana Montella, Francesco Perna, Paola Orlandi, Gianfranco Abbate, Serafino Zappacosta, Raffaele De Palma, and Luigi Racioppi. “Clonal expansion of CD8+ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia.” Blood 101, no. 8 (April 15, 2003): 3106–8. https://doi.org/10.1182/blood-2002-08-2638.
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    • Matarese, G., G. Castelli-Gattinara, C. Cancrini, S. Bernardi, M. L. Romiti, C. Savarese, A. Di Giacomo, P. Rossi, and L. Racioppi. “Serum leptin and CD4+ T lymphocytes in HIV+ children during highly active antiretroviral therapy.” Clin Endocrinol (Oxf) 57, no. 5 (November 2002): 643–46. https://doi.org/10.1046/j.1365-2265.2002.01634.x.
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    • Cancrini, C., M. L. Romiti, S. Di Cesare, F. Angelini, D. Gigliotti, S. Livadiotti, E. Bertini, P. Rossi, and L. Racioppi. “Restriction in T-cell receptor repertoire in a patient affected by trichothiodystrophy and CD4+ lymphopenia.” Scand J Immunol 56, no. 2 (August 2002): 212–16. https://doi.org/10.1046/j.1365-3083.2002.01122.x.
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    • Buonaguro, L., L. Racioppi, M. L. Tornesello, C. Arra, M. L. Visciano, B. Biryahwaho, S. D. K. Sempala, G. Giraldo, and F. M. Buonaguro. “Induction of neutralizing antibodies and cytotoxic T lymphocytes in Balb/c mice immunized with virus-like particles presenting a gp120 molecule from a HIV-1 isolate of clade A.” Antiviral Res 54, no. 3 (June 2002): 189–201. https://doi.org/10.1016/s0166-3542(02)00004-9.
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    • Racioppi, L., C. Cancrini, M. L. Romiti, F. Angelini, S. Di Cesare, E. Bertini, S. Livadiotti, et al. “Defective dendritic cell maturation in a child with nucleotide excision repair deficiency and CD4 lymphopenia.” Clin Exp Immunol 126, no. 3 (December 2001): 511–18. https://doi.org/10.1046/j.1365-2249.2001.01625.x.
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    • Lago Paz, F., M. Galgani, U. D’Oro, G. Matarese, A. M. Masci, S. Zappacosta, and L. Racioppi. “Modulation of CD45 tyrosine phosphatase activity by antigen.” Eur J Immunol 31, no. 3 (March 2001): 777–82. https://doi.org/10.1002/1521-4141(200103)31:3<777::aid-immu777>3.0.co;2-i.
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    • Pignata, C., L. Gaetaniello, A. M. Masci, J. Frank, A. Christiano, E. Matrecano, and L. Racioppi. “Human equivalent of the mouse Nude/SCID phenotype: long-term evaluation of immunologic reconstitution after bone marrow transplantation.” Blood 97, no. 4 (February 15, 2001): 880–85. https://doi.org/10.1182/blood.v97.4.880.
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    • Montanaro, D., V. Sanna, G. Matarese, B. B. Larby, L. Racioppi, P. B. Carrieri, R. Bruno, N. J. Davey, S. Zappacosta, and S. Fontana. “The fine specificity of human T cell lines towards myelin basic protein peptides in southern Italian multiple sclerosis patients.” Clin Exp Immunol 123, no. 2 (February 2001): 288–93. https://doi.org/10.1046/j.1365-2249.2001.01457.x.
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    • Ragione, F. D., V. Cucciolla, A. Borriello, V. D. Pietra, G. Pontoni, L. Racioppi, C. Manna, P. Galletti, and V. Zappia. “Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis.” Biochem Biophys Res Commun 278, no. 3 (November 30, 2000): 733–39. https://doi.org/10.1006/bbrc.2000.3875.
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    • Biasin, M., S. L. Caputo, L. Speciale, F. Colombo, L. Racioppi, A. Zagliani, C. Blé, et al. “Mucosal and systemic immune activation is present in human immunodeficiency virus-exposed seronegative women.” J Infect Dis 182, no. 5 (November 2000): 1365–74. https://doi.org/10.1086/315873.
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    • Del Giudice, E., L. Gaetaniello, E. Matrecano, E. Cosentini, M. V. Ursini, L. Racioppi, G. Arrigo, and C. Pignata. “Brain migration disorder and T-cell activation deficiency associated with abnormal signaling through TCR/CD3 complex and hyperactivity of Fyn tyrosine kinase.” Neuropediatrics 31, no. 5 (October 2000): 265–68. https://doi.org/10.1055/s-2000-9234.
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    • Masci, A. M., G. Palmieri, F. Perna, L. Montella, G. Merkabaoui, G. Sacerdoti, A. Martignetti, and L. Racioppi. “Immunological findings in thymoma and thymoma-related syndromes.” Ann Med 31 Suppl 2 (October 1999): 86–89.
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    • Masci, A. M., F. L. Paz, A. Borriello, S. Cassano, V. Della Pietra, H. Stoiber, G. Matarese, F. Della Ragione, S. Zappacosta, and L. Racioppi. “Effects of human immunodeficiency virus type 1 on CD4 lymphocyte subset activation.” Eur J Immunol 29, no. 6 (June 1999): 1879–89. https://doi.org/10.1002/(SICI)1521-4141(199906)29:06<1879::AID-IMMU1879>3.0.CO;2-2.
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    • De Placido, G., C. Alviggi, G. Di Palma, C. Carravetta, G. Matarese, G. Landino, and L. Racioppi. “Serum concentrations of soluble human leukocyte class I antigens and of the soluble intercellular adhesion molecule-1 in endometriosis: relationship with stage and non-pigmented peritoneal lesions.” Hum Reprod 13, no. 11 (November 1998): 3206–10. https://doi.org/10.1093/humrep/13.11.3206.
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    • Ragione, F. D., V. Cucciolla, A. Borriello, V. D. Pietra, L. Racioppi, G. Soldati, C. Manna, P. Galletti, and V. Zappia. “Resveratrol arrests the cell division cycle at S/G2 phase transition.” Biochem Biophys Res Commun 250, no. 1 (September 8, 1998): 53–58. https://doi.org/10.1006/bbrc.1998.9263.
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    • POZZI, N. “Combined signal transduction abnormalities through TCR and growth hormone (GH) receptors in 2 unrelated patients.” Molecular Immunology 35, no. 11–12 (August 1998): 716–716. https://doi.org/10.1016/s0161-5890(98)90374-1.
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    • Scotese, I., L. Gaetaniello, G. Matarese, M. Lecora, L. Racioppi, and C. Pignata. “T cell activation deficiency associated with an aberrant pattern of protein tyrosine phosphorylation after CD3 perturbation in Down's syndrome.” Pediatr Res 44, no. 2 (August 1998): 252–58. https://doi.org/10.1203/00006450-199808000-00019.
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    • Racioppi, L., G. Matarese, U. D’Oro, M. De Pascale, A. M. Masci, S. Fontana, and S. Zappacosta. “The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling.” Proc Natl Acad Sci U S A 93, no. 19 (September 17, 1996): 10360–65. https://doi.org/10.1073/pnas.93.19.10360.
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    • Jeso, B. di, L. Ulianich, L. Racioppi, F. D’Armiento, A. Feliciello, F. Pacifico, E. Consiglio, and S. Formisano. “Serum withdrawal induces apoptotic cell death in Ki-ras transformed but not in normal differentiated thyroid cells.” Biochem Biophys Res Commun 214, no. 3 (September 25, 1995): 819–24. https://doi.org/10.1006/bbrc.1995.2360.
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    • Masci, A. M., S. Scala, L. Racioppi, and S. Zappacosta. “Cell surface expression of major histocompatibility class I antigens is modulated by P-glycoprotein transporter.” Hum Immunol 42, no. 3 (March 1995): 245–53. https://doi.org/10.1016/0198-8859(94)00096-9.
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    • Racioppi, L., and R. N. Germain. “Modified T-cell receptor ligands: moving beyond a strict occupancy model for T-cell activation by antigen.” Chem Immunol 60 (1995): 79–99.
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    • Boehncke, W. H., T. Takeshita, C. D. Pendleton, R. A. Houghten, S. Sadegh-Nasseri, L. Racioppi, J. A. Berzofsky, and R. N. Germain. “The Importance of Dominant Negative Effects of Amino Acid Side Chain Substitution in Peptide-MHC Molecule Interactions and T Cell Recognition.” Journal of Immunology 150, no. 2 (December 1, 1993): 331341.
    • Di Rosa, F., U. D’Oro, G. Ruggiero, L. Racioppi, A. Acquaviva, S. Ferrone, S. Fontana, and S. Zappacosta. “HLA class II molecules transduce accessory signals affecting the CD3 but not the interleukin-2 activation pathway in T blasts.” Hum Immunol 38, no. 4 (December 1993): 251–60. https://doi.org/10.1016/0198-8859(93)90552-c.
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    • Racioppi, L., F. Ronchese, L. A. Matis, and R. N. Germain. “Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling.” J Exp Med 177, no. 4 (April 1, 1993): 1047–60. https://doi.org/10.1084/jem.177.4.1047.
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    • Boehncke, W. H., T. Takeshita, C. D. Pendleton, R. A. Houghten, S. Sadegh-Nasseri, L. Racioppi, J. A. Berzofsky, and R. N. Germain. “The importance of dominant negative effects of amino acid side chain substitution in peptide-MHC molecule interactions and T cell recognition.” J Immunol 150, no. 2 (January 15, 1993): 331–41.
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    • RACIOPPI, L. “Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling.” J Exp Med 177 (1993): 1047–60. https://doi.org/10.1084/jem.177.4.1047.
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    • Racioppi, L., F. Ronchese, R. H. Schwartz, and R. N. Germain. “The molecular basis of class II MHC allelic control of T cell responses.” J Immunol 147, no. 11 (December 1, 1991): 3718–27.
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    • Carbone, E., L. Racioppi, A. La Cava, G. Portella, F. Velotti, S. Zappacosta, and S. Fontana. “NK and LAK susceptibility varies inversely with target cell MHC class I antigen expression in a rat epithelial tumour system.” Scand J Immunol 33, no. 2 (February 1991): 185–94. https://doi.org/10.1111/j.1365-3083.1991.tb03748.x.
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    • RACIOPPI, L. “The molecular basis of class II MHC allelic control of T cell responses.” J. Immunol. 147 (1991).
    • Ruggiero, G., L. Racioppi, C. Manzo, G. Pirozzi, U. D’Oro, S. Ferrone, S. Zappacosta, and S. Fontana. “HLA class II molecules on monocytes regulate T cell proliferation through physical interaction in the CD3 activation pathway.” Eur J Immunol 21, no. 1 (January 1991): 29–33. https://doi.org/10.1002/eji.1830210106.
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    • Racioppi, L., A. Moscarella, G. Ruggiero, C. Manzo, S. Ferrone, S. Fontana, and S. Zappacosta. “Inhibition by anti-HLA class II monoclonal antibodies of monoclonal antibody OKT3-induced T cell proliferation. Studies at the mRNA level.” J Immunol 145, no. 11 (December 1, 1990): 3635–40.
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    • Manzo, C., G. Ruggiero, L. del Vecchio, L. Racioppi, G. Pirozzi, M. Temponi, S. Ferrone, S. Fontana, and S. Zappacosta. “Monoclonal antibody OKT3-induced T cell proliferation: differential role of HLA class II determinants expressed by T cells and monocytes.” Cell Immunol 125, no. 1 (January 1990): 79–91. https://doi.org/10.1016/0008-8749(90)90064-x.
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    • Racioppi, L., E. Carbone, M. Grieco, L. Del Vecchio, M. T. Berlingieri, A. Fusco, E. Boncinelli, S. Zappacosta, and S. Fontana. “The relationship of modulation of major histocompatibility complex class I antigens to retrovirus transformation in rat cell lines.” Cancer Res 48, no. 13 (July 1, 1988): 3816–21.
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    • Fontana, S., L. Del Vecchio, L. Racioppi, E. Carbone, A. Pinto, G. Colletta, and S. Zappacosta. “Expression of major histocompatibility complex class I antigens in normal and transformed rat thyroid epithelial cell lines.” Cancer Res 47, no. 15 (August 1, 1987): 4178–83.
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  • Conference Papers

    • Mukherjee, Debarati, Robert Baldi, Ching-Yi Chang, Luigi Racioppi, and Donald P. McDonnell. “Impact of CaMKK2 inhibition in tumor-associated myeloid cells on CD8+cytotoxic T-cell recruitment into mammary tumors.” In Cancer Immunology Research, 8:56–57. AMER ASSOC CANCER RESEARCH, 2020.
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    • Jauhari, Shekeab, Alicia D. Volkheimer, Ian Barak, Eross Guadalupe, J Brice Weinberg, Nelson Jen An Chao, Zhiguo Li, and Luigi Racioppi. “Expression and prognostic relevance of calcium calmodulin-dependent protein kinase kinase 2 (CaMKK2) in chronic lymphocytic leukemia (CLL).” In Journal of Clinical Oncology, Vol. 37. AMER SOC CLINICAL ONCOLOGY, 2019.
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    • Huang, Wei, Yaping Liu, Nelson J. Chao, and Luigi Racioppi. “Calcium/Calmodulin Dependent Protein Kinase Kinase 2 (CaMKK2) Expressed in the Host Promotes Lymphoma Cells Growth By Controlling Myeloid Derived Suppressor Cells Expansion.” In Blood, 132:272–272. American Society of Hematology, 2018. https://doi.org/10.1182/blood-2018-99-117147.
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    • Vitiello, L., E Elisabetta Ferraro, S. De Simone, G. Rosano, and L. Racioppi. “Exposure to CXCL12 prolonges naive CD4+T lymphocytes survival.” In European Journal of Heart Failure, 18:282–282. WILEY-BLACKWELL, 2016.
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    • Lento, William, Wei Huang, Doan Phuong, Nelson J. Chao, and Luigi Racioppi. “Calcium Calmodulin Dependent Kinase Kinase 2 Regulates Hematopoietic Stem Cell Regeneration and Quiescence.” In Blood, Vol. 124. AMER SOC HEMATOLOGY, 2014.
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    • Racioppi, Luigi, Pamela Noeldner, Fumin Lin, Stephanie Arvai, and Anthony Means. “Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 Regulates Macrophage-Mediated Inflammatory Responses.” In Journal of Immunology, Vol. 188. AMER ASSOC IMMUNOLOGISTS, 2012.
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    • Tortora, Giampaolo, Sonia Garofalo, Rosa Caputo, Roberto Bianco, Roberta Rosa, Teresa Gelardi, Gerardina Merola, et al. “Toll-like receptor 9 (TLR9) interacts with ErbB receptors at membrane level and a TLR9 agonist synergizes with trastuzumab in trastuzumab-resistant breast cancer xenografts via modulation of ErbB signalling.” In Cancer Research, Vol. 69. AMER ASSOC CANCER RESEARCH, 2009.
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    • Perrella, Alessandro, Luigi Racioppi, Luigi Atripaldi, Simona Pisanti, Costanza Sbreglia, Pasquale Bellopede, and Oreste Perrella. “HBV vaccination with evidence of protective antibodies titer induces CD4+/CD25+T cells.” In Gastroenterology, 130:A849–A849. W B SAUNDERS CO-ELSEVIER INC, 2006.
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    • Perrella, Alessandro, Luigi Racioppi, Luigi Atripaldi, Laura Vitiello, Simona Pisanti, Pasquale Bellopede, Tommaso Patarino, Raffaele Vela, Tiziana Ascione, and Oreste Perrella. “Elevated CD4+/CD25+ regulatory T cell frequency and function in acute hepatitis C genotype 1, presage chronic evolution.” In Journal of Gastroenterology and Hepatology, 21:A114–A114. BLACKWELL PUBLISHING, 2006.
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    • Perrella, Alessandro, Luigi Racioppi, Simona Pisanti, Laura Vitiello, Salvatore De Simone, Costanza Sbreglia, Pasquale Bellopede, Tommaso Patarino, Lugi Atripaldi, and Oreste Perrella. “Increase CD4+/CD25+ T cells frequency and function occur after HBV vaccine administration at protective titer.” In Journal of Gastroenterology and Hepatology, 21:A113–14. BLACKWELL PUBLISHING, 2006.
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    • Tortora, Giampaolo, Rosa Caputo, Roberto Bianco, Sonia Garofalo, Luigi Racioppi, Angelo R. Bianco, Roberta Rosa, Fortunato Ciardiello, Sudhir Agrawal, and Vincenzo Damiano. “Novel anticancer drugs TLR9 agonists act by interfering with EGFR and VEGF signalling and synergize with EGFR inhibitors and with bevacizumab in wild type and cetuximab-resistant colon cancer xenografts.” In Annals of Oncology, 17:137–137. OXFORD UNIV PRESS, 2006.
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    • Perrella, A., L. Racioppi, L. Atripaldi, C. Sbregia, P. Bellopede, T. Patarino, R. Vela, R. De Sena, and O. Perrella. “Elevated CD4+/CD25+ regulatory T cell frequency and function in acute hepatitis C genotype 1, presage chronic evolution.” In Immunology, 116:79–79. BLACKWELL PUBLISHING, 2005.
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    • Perrella, A., L. Atripaldi, L. Racioppi, P. Conti, and O. Perrella. “Elevated CD4+/CD25+ regulatory T cell number and function in acute hepatitis C genotype 1, presage chronic evolution.” In Hepatology, 42:541A-541A. JOHN WILEY & SONS INC, 2005.
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    • Perrella, A., L. Racioppi, L. Atripaldi, P. Conti, C. Sbreglia, P. Bellopede, and O. Perrella. “Resolution of acute HBV infection is associated with a highest frequency and function of CD3+/CD4+/CD25+T cells.” In Hepatology, 42:713A-713A. JOHN WILEY & SONS INC, 2005.
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    • Busiello, R., S. Fecarotta, G. Giordano, M. V. Ursini, M. Galgani, L. Racioppi, and C. Pignata. “Fatal rapidly progressive liver disease associated to a novel mutation of the perforin gene.” In Blood, 100:466A-466A. AMER SOC HEMATOLOGY, 2002.
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    • Gaetaniello, L., I. Scotese, G. Matarese, S. deFilippo, L. Racioppi, and C. Pignata. “Abnormal tyrosine phosphorylated 30 kDa protein in a patient with immunodeficiency and severe encephalopathy associated with a constitutive activation of the MAPK cascade.” In Blood, 88:1982–1982. W B SAUNDERS CO, 1996.
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    • RACIOPPI, L., F. RONCHESE, R. SCHWARTZ, and R. GERMAIN. “QUANTITATIVE AND QUALITATIVE EFFECTS OF CLASS-II MHC MOLECULE POLYMORPHISM ON PEPTIDE BINDING.” In Faseb Journal, 5:A724–A724. FEDERATION AMER SOC EXP BIOL, 1991.
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    • FONTANA, S., L. RACIOPPI, E. CARBONE, G. COLLETTA, and S. ZAPPACOSTA. “EXPRESSION OF MHC CLASS-I ANTIGENS IN TRANSFORMED RAT-THYROID EPITHELIAL LINES.” In Annales D Endocrinologie, 47:71–71. MASSON EDITEUR, 1986.
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