Luigi Racioppi | Scholars@Duke

Luigi Racioppi
Assistant Professor in Medicine

Current Appointments & Affiliations

Assistant Professor in Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2011

Contact Information

103866 - 2006 GSRB1, Durham, NC 27710
905 S. Lasalle St, 2006 GSRB1, Durham, NC 27710
luigi.racioppi@duke.edu (919) 681-6212

Background
Education, Training, & Certifications
- M.D., University of Naples Federico II (Italy) 1985
- Ph.D., University of Naples Federico II (Italy) 1982
Duke Appointment History
- Visiting Professor in the Department of Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2006
Research
Selected Grants
- Cancer cell intrinsic and extrinsic actions of steroid hormones in breast tumors awarded by Department of Defense 2018 - 2022
- Development of CaMKK2 inhibitor drug for acute radiation syndrome awarded by Columbia University 2018 - 2019
- Identify chemical probes for CAMKK2 to target the tumor microenvironment and enhance anti-tumor immune response awarded by University of North Carolina - Chapel Hill 2017 - 2019
- Macrophages and Treatment-Resistant NVAMD awarded by National Institutes of Health 2015 - 2019
- Determining the mechanism of the protective of action of STO-609, a CaMKK2 inhibitor, in acute radiation syndrome awarded by Columbia University 2016 - 2018
- CaMKK2: a druggable target that regulates macrophage function in breast cancer awarded by Susan G. Komen Breast Cancer Foundation 2013 - 2017
- A novel therapeutic target for radiation-induced hematological malignancies: calcium calmodulin kinase kinase 2 awarded by Department of Defense 2015 - 2017
- CaM Kinase Cascades in Endocrine Cells awarded by National Institutes of Health 1997 - 2011
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Racioppi, L, Lento, W, Huang, W, Arvai, S, Doan, PL, Harris, JR, Marcon, F, Nakaya, HI, Liu, Y, and Chao, N. "Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration." Cell Death & Disease 8, no. 10 (October 5, 2017): e3076-null. Full Text
  - Vitiello, L, Ferraro, E, De Simone, S, Gatta, L, Feraco, A, Racioppi, L, and Rosano, G. "CXCL12 prolongs naive CD4+ T lymphocytes survival via activation of PKA, CREB and Bcl2 and BclXl up-regulation." International journal of cardiology 224 (December 2016): 206-212. Full Text
  - Lento, W, Ito, T, Zhao, C, Harris, JR, Huang, W, Jiang, C, Owzar, K, Piryani, S, Racioppi, L, Chao, N, and Reya, T. "Loss of β-catenin triggers oxidative stress and impairs hematopoietic regeneration." Genes & Development 28, no. 9 (May 2014): 995-1004. Full Text
  - Cary, RL, Waddell, S, Racioppi, L, Long, F, Novack, DV, Voor, MJ, and Sankar, U. "Inhibition of Ca²⁺/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research 28, no. 7 (July 2013): 1599-1610. Full Text
  - Racioppi, L. "CaMKK2: a novel target for shaping the androgen-regulated tumor ecosystem." Trends Mol Med 19, no. 2 (February 2013): 83-88. (Review) Full Text Link to Item
  - Roach, JM, Racioppi, L, Jones, CD, and Masci, AM. "Phylogeny of Toll-like receptor signaling: adapting the innate response." PLoS One 8, no. 1 (2013): e54156-. Full Text Link to Item
  - Racioppi, L, and Means, AR. "Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology." The Journal of Biological Chemistry 287, no. 38 (September 2012): 31658-31665. (Review) Full Text
  - Racioppi, L, Noeldner, PK, Lin, F, Arvai, S, and Means, AR. "Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses." The Journal of Biological Chemistry 287, no. 14 (March 2012): 11579-11591. Full Text
  - Barberi, TJ, Dunkle, A, He, Y-W, Racioppi, L, and Means, AR. "The prolyl isomerase Pin1 modulates development of CD8+ cDC in mice." PLoS One 7, no. 1 (2012): e29808-. Full Text Link to Item
  - Teng, EC, Racioppi, L, and Means, AR. "A cell-intrinsic role for CaMKK2 in granulocyte lineage commitment and differentiation." J Leukoc Biol 90, no. 5 (November 2011): 897-909. Full Text Link to Item
  - Cancrini, C, Scarselli, A, Scaramuzza, S, Chiriaco, M, Di Cesare, S, Di Matteo, G, Romiti, ML, Palma, P, De Felice, L, Palumbo, G, Pinto, RM, De Vito, R, Racioppi, L, Livadiotti, S, Fischer, A, Rossi, P, Caniglia, M, and Aiuti, A. "Early-onset monocyte-B-natural killer-dendritic cells' deficiency successfully treated with hematopoietic stem cell transplantation." J Allergy Clin Immunol 128, no. 4 (October 2011): 897-900.e1. (Letter) Full Text Link to Item
  - Nakaya, HI, Wrammert, J, Lee, EK, Racioppi, L, Marie-Kunze, S, Haining, WN, Means, AR, Kasturi, SP, Khan, N, Li, G-M, McCausland, M, Kanchan, V, Kokko, KE, Li, S, Elbein, R, Mehta, AK, Aderem, A, Subbarao, K, Ahmed, R, and Pulendran, B. "Systems biology of vaccination for seasonal influenza in humans." Nature Immunology 12, no. 8 (July 10, 2011): 786-795. Full Text
  - Vigliano, I, Gorrese, M, Fusco, A, Vitiello, L, Amorosi, S, Panico, L, Ursini, MV, Calcagno, G, Racioppi, L, Del Vecchio, L, and Pignata, C. "FOXN1 mutation abrogates prenatal T-cell development in humans." Journal of Medical Genetics 48, no. 6 (June 2011): 413-416. Full Text
  - Vigliano, I, Gorrese, M, Fusco, A, Vitiello, L, Amorosi, S, Panico, L, Ursini, MV, Calcagno, G, Racioppi, L, Vecchio, LD, and Pignata, C. "FOXN1 mutation abrogates prenatal T-cell development in humans." Journal of Medical Genetics (2011). Full Text
  - Giardino Torchia, ML, Ciaglia, E, Masci, AM, Vitiello, L, Fogli, M, la Sala, A, Mavilio, D, and Racioppi, L. "Dendritic cells/natural killer cross-talk: a novel target for human immunodeficiency virus type-1 protease inhibitors. (Published online)" PLoS One 5, no. 6 (June 10, 2010): e11052-. Full Text Link to Item
  - Torchia, MLG, Ciaglia, E, Masci, AM, Vitiello, L, Fogli, M, Sala, AL, Mavilio, D, and Racioppi, L. "Dendritic cells/natural killer cross-talk: A novel target for human immunodeficiency virus type-1 protease inhibitors." PLoS ONE 5, no. 6 (2010). Full Text
  - Vitiello, L, Masci, AM, Montella, L, Perna, F, Angelini, DF, Borsellino, G, Battistini, L, Merola, G, De Palma, R, Spadaro, G, Cosentini, E, Palmieri, G, and Racioppi, L. "Thymoma-associated immunodeficiency: a syndrome characterized by severe alterations in NK, T and B-cells and progressive increase in naïve CD8+ T Cells." International Journal of Immunopathology and Pharmacology 23, no. 1 (January 2010): 307-316. Full Text
  - Damiano, V, Garofalo, S, Rosa, R, Bianco, R, Caputo, R, Gelardi, T, Merola, G, Racioppi, L, Garbi, C, Kandimalla, ER, Agrawal, S, and Tortora, G. "A novel toll-like receptor 9 agonist cooperates with trastuzumab in trastuzumab-resistant breast tumors through multiple mechanisms of action." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 15, no. 22 (November 10, 2009): 6921-6930. Full Text
  - Racioppi, L, and Means, AR. "Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller." Trends in Immunology 29, no. 12 (December 2008): 600-607. (Review) Full Text
  - Perrella, A, Vitiello, L, Atripaldi, L, Sbreglia, C, Grattacaso, S, Bellopede, P, Patarino, T, Morelli, G, Altamura, S, Racioppi, L, and Perrella, O. "Impaired function of CD4+/CD25+ T regulatory lymphocytes characterizes the self-limited hepatitis A virus infection." Journal of Gastroenterology and Hepatology 23, no. 7 Pt 2 (July 2008): e105-e110. Full Text
  - Illario, M, Giardino-Torchia, ML, Sankar, U, Ribar, TJ, Galgani, M, Vitiello, L, Masci, AM, Bertani, FR, Ciaglia, E, Astone, D, Maulucci, G, Cavallo, A, Vitale, M, Cimini, V, Pastore, L, Means, AR, Rossi, G, and Racioppi, L. "Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells." Blood 111, no. 2 (January 2008): 723-731. Full Text
  - Lambiase, A, Normando, EM, Vitiello, L, Micera, A, Sacchetti, M, Perrella, E, Racioppi, L, Bonini, S, and Bonini, S. "Natural killer cells in vernal keratoconjunctivitis. (Published online)" Mol Vis 13 (August 30, 2007): 1562-1567. Link to Item
  - Damiano, V, Caputo, R, Garofalo, S, Bianco, R, Rosa, R, Merola, G, Gelardi, T, Racioppi, L, Fontanini, G, De Placido, S, Kandimalla, ER, Agrawal, S, Ciardiello, F, and Tortora, G. "TLR9 agonist acts by different mechanisms synergizing with bevacizumab in sensitive and cetuximab-resistant colon cancer xenografts." Proceedings of the National Academy of Sciences of the United States of America 104, no. 30 (July 16, 2007): 12468-12473. Full Text
  - de Laurentiis, G, Vitiello, L, Racioppi, L, Perna, F, Galgani, M, Merola, G, Carratù, P, Maniscalco, M, Marsico, S, and Sofia, M. "CD8+ T-cell alveolitis in familial pulmonary alveolar microlithiasis." Eur Respir J 30, no. 1 (July 2007): 165-171. Full Text Link to Item
  - Palmieri, G, Selleri, C, Montella, L, Bulgarelli, G, Vitiello, L, Merkabaoui, G, Ricci, P, Del Vecchio, L, Masci, A, Racioppi, L, and Rotoli, B. "Thymoma followed by paroxysmal nocturnal hemoglobinuria: a unique clinical association in the context of multiorgan autoimmunity with a potential role for CD8+ T lymphocytes." Am J Hematol 81, no. 10 (October 2006): 774-778. Full Text Link to Item
  - Perrella, A, Vitiello, L, Atripaldi, L, Conti, P, Sbreglia, C, Altamura, S, Patarino, T, Vela, R, Morelli, G, Bellopede, P, Alone, C, Racioppi, L, and Perrella, O. "Elevated CD4+/CD25+ T cell frequency and function during acute hepatitis C presage chronic evolution." Gut 55, no. 9 (September 2006): 1370-1371. (Letter) Full Text Link to Item
  - Scottà, C, Tuosto, L, Masci, AM, Racioppi, L, Piccolella, E, and Frasca, L. "Hypervariable region 1 variant acting as TCR antagonist affects hepatitis C virus-specific CD4+ T cell repertoire by favoring CD95-mediated apoptosis." J Leukoc Biol 78, no. 2 (August 2005): 372-382. Full Text Link to Item
  - Montella, L, Merkabaoui, G, Vitiello, L, Bulgarelli, G, Sinagra, G, Masci, AM, Racioppi, L, and Palmieri, G. "Fatal immunodeficiency in a patient with thymoma and Good's syndrome." Tumori 91, no. 4 (July 2005): 361-363. Link to Item
  - Auricchio, L, Vitiello, L, Adriani, M, Ferri, P, Chiocchetti, A, Pettinato, G, Racioppi, L, Maiuri, L, Dianzani, U, and Pignata, C. "Cutaneous manifestations as presenting sign of autoimmune lymphoproliferative syndrome in childhood." Dermatology (Basel, Switzerland) 210, no. 4 (January 2005): 336-340. Full Text
  - Ruggiero, G, Terrazzano, G, Becchimanzi, C, Sica, M, Andretta, C, Masci, AM, Racioppi, L, Rotoli, B, Zappacosta, S, and Alfinito, F. "GPI-defective monocytes from paroxysmal nocturnal hemoglobinuria patients show impaired in vitro dendritic cell differentiation." J Leukoc Biol 76, no. 3 (September 2004): 634-640. Full Text Link to Item
  - Galgani, M, Busiello, I, Censini, S, Zappacosta, S, Racioppi, L, and Zarrilli, R. "Helicobacter pylori induces apoptosis of human monocytes but not monocyte-derived dendritic cells: role of the cag pathogenicity island." Infection and Immunity 72, no. 8 (August 2004): 4480-4485. Full Text
  - Galgani, M, De Rosa, V, De Simone, S, Leonardi, A, D'Oro, U, Napolitani, G, Masci, AM, Zappacosta, S, and Racioppi, L. "Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling." J Biol Chem 279, no. 31 (July 30, 2004): 32507-32514. Full Text Link to Item
  - Busiello, R, Adriani, M, Locatelli, F, Galgani, M, Fimiani, G, Clementi, R, Ursini, MV, Racioppi, L, and Pignata, C. "Atypical features of familial hemophagocytic lymphohistiocytosis." Blood 103, no. 12 (June 15, 2004): 4610-4612. Full Text Link to Item
  - Stadt, UZ, Beutel, K, Weber, B, Kabisch, H, Schneppenheim, R, Janka, G, Busiello, R, Galgani, M, Fusco, CD, Poggi, V, Adriani, M, Racioppi, L, and Pignata, C. "A91V is a polymorphism in the perform gene not causative of an FHLH phenotype [2] (multiple letters)." Blood 104, no. 6 (2004): 1909-1910. Full Text
  - Masci, AM, Galgani, M, Cassano, S, De Simone, S, Gallo, A, De Rosa, V, Zappacosta, S, and Racioppi, L. "HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling." J Leukoc Biol 74, no. 6 (December 2003): 1117-1124. Full Text Link to Item
  - Napolitani, G, Bortoletto, N, Racioppi, L, Lanzavecchia, A, and D'Oro, U. "Activation of src-family tyrosine kinases by LPS regulates cytokine production in dendritic cells by controlling AP-1 formation." Eur J Immunol 33, no. 10 (October 2003): 2832-2841. Full Text Link to Item
  - Frasca, L, Scottà, C, Del Porto, P, Nicosia, A, Pasquazzi, C, Versace, I, Masci, AM, Racioppi, L, and Piccolella, E. "Antibody-selected mimics of hepatitis C virus hypervariable region 1 activate both primary and memory Th lymphocytes." Hepatology 38, no. 3 (September 2003): 653-663. Full Text Link to Item
  - Montella, L, Masci, AM, Merkabaoui, G, Perna, F, Vitiello, L, Racioppi, L, and Palmieri, G. "B-cell lymphopenia and hypogammaglobulinemia in thymoma patients." Ann Hematol 82, no. 6 (June 2003): 343-347. Full Text Link to Item
  - Masci, AM, Palmieri, G, Vitiello, L, Montella, L, Perna, F, Orlandi, P, Abbate, G, Zappacosta, S, De Palma, R, and Racioppi, L. "Clonal expansion of CD8+ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia." Blood 101, no. 8 (April 15, 2003): 3106-3108. Full Text Link to Item
  - Matarese, G, Castelli-Gattinara, G, Cancrini, C, Bernardi, S, Romiti, ML, Savarese, C, Di Giacomo, A, Rossi, P, and Racioppi, L. "Serum leptin and CD4+ T lymphocytes in HIV+ children during highly active antiretroviral therapy." Clin Endocrinol (Oxf) 57, no. 5 (November 2002): 643-646. Link to Item
  - Cancrini, C, Romiti, ML, Di Cesare, S, Angelini, F, Gigliotti, D, Livadiotti, S, Bertini, E, Rossi, P, and Racioppi, L. "Restriction in T-cell receptor repertoire in a patient affected by trichothiodystrophy and CD4+ lymphopenia." Scand J Immunol 56, no. 2 (August 2002): 212-216. Link to Item
  - Buonaguro, L, Racioppi, L, Tornesello, ML, Arra, C, Visciano, ML, Biryahwaho, B, Sempala, SD, Giraldo, G, and Buonaguro, FM. "Induction of neutralizing antibodies and cytotoxic T lymphocytes in Balb/c mice immunized with virus-like particles presenting a gp120 molecule from a HIV-1 isolate of clade A." Antiviral Research 54, no. 3 (June 2002): 189-201. Full Text
  - Racioppi, L, Cancrini, C, Romiti, ML, Angelini, F, Di Cesare, S, Bertini, E, Livadiotti, S, Gambarara, MG, Matarese, G, Lago Paz, F, Stefanini, M, and Rossi, P. "Defective dendritic cell maturation in a child with nucleotide excision repair deficiency and CD4 lymphopenia." Clin Exp Immunol 126, no. 3 (December 2001): 511-518. Link to Item
  - Lago Paz, F, Galgani, M, D'Oro, U, Matarese, G, Masci, AM, Zappacosta, S, and Racioppi, L. "Modulation of CD45 tyrosine phosphatase activity by antigen." European Journal of Immunology 31, no. 3 (March 2001): 777-782. Full Text
  - Pignata, C, Gaetaniello, L, Masci, AM, Frank, J, Christiano, A, Matrecano, E, and Racioppi, L. "Human equivalent of the mouse Nude/SCID phenotype: long-term evaluation of immunologic reconstitution after bone marrow transplantation." Blood 97, no. 4 (February 15, 2001): 880-885. Link to Item
  - Montanaro, D, Sanna, V, Matarese, G, Larby, BB, Racioppi, L, Carrieri, PB, Bruno, R, Davey, NJ, Zappacosta, S, and Fontana, S. "The fine specificity of human T cell lines towards myelin basic protein peptides in southern Italian multiple sclerosis patients." Clin Exp Immunol 123, no. 2 (February 2001): 288-293. Link to Item
  - Ragione, FD, Cucciolla, V, Borriello, A, Pietra, VD, Pontoni, G, Racioppi, L, Manna, C, Galletti, P, and Zappia, V. "Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis." Biochem Biophys Res Commun 278, no. 3 (November 30, 2000): 733-739. Full Text Link to Item
  - Biasin, M, Caputo, SL, Speciale, L, Colombo, F, Racioppi, L, Zagliani, A, Blé, C, Vichi, F, Cianferoni, L, Masci, AM, Villa, ML, Ferrante, P, Mazzotta, F, and Clerici, M. "Mucosal and systemic immune activation is present in human immunodeficiency virus-exposed seronegative women." The Journal of Infectious Diseases 182, no. 5 (November 2000): 1365-1374. Full Text
  - Del Giudice, E, Gaetaniello, L, Matrecano, E, Cosentini, E, Ursini, MV, Racioppi, L, Arrigo, G, and Pignata, C. "Brain migration disorder and T-cell activation deficiency associated with abnormal signaling through TCR/CD3 complex and hyperactivity of Fyn tyrosine kinase." Neuropediatrics 31, no. 5 (October 2000): 265-268. Full Text Link to Item
  - Masci, AM, Palmieri, G, Perna, F, Montella, L, Merkabaoui, G, Sacerdoti, G, Martignetti, A, and Racioppi, L. "Immunological findings in thymoma and thymoma-related syndromes." Ann Med 31 Suppl 2 (October 1999): 86-89. Link to Item
  - Masci, AM, Paz, FL, Borriello, A, Cassano, S, Della Pietra, V, Stoiber, H, Matarese, G, Della Ragione, F, Zappacosta, S, and Racioppi, L. "Effects of human immunodeficiency virus type 1 on CD4 lymphocyte subset activation." European Journal of Immunology 29, no. 6 (June 1999): 1879-1889. Full Text
  - De Placido, G, Alviggi, C, Di Palma, G, Carravetta, C, Matarese, G, Landino, G, and Racioppi, L. "Serum concentrations of soluble human leukocyte class I antigens and of the soluble intercellular adhesion molecule-1 in endometriosis: relationship with stage and non-pigmented peritoneal lesions." Hum Reprod 13, no. 11 (November 1998): 3206-3210. Link to Item
  - Ragione, FD, Cucciolla, V, Borriello, A, Pietra, VD, Racioppi, L, Soldati, G, Manna, C, Galletti, P, and Zappia, V. "Resveratrol arrests the cell division cycle at S/G2 phase transition." Biochemical and Biophysical Research Communications 250, no. 1 (September 1998): 53-58. Full Text
  - Scotese, I, Gaetaniello, L, Matarese, G, Lecora, M, Racioppi, L, and Pignata, C. "T cell activation deficiency associated with an aberrant pattern of protein tyrosine phosphorylation after CD3 perturbation in Down's syndrome." Pediatr Res 44, no. 2 (August 1998): 252-258. Full Text Link to Item
  - Racioppi, L, Matarese, G, D'Oro, U, De Pascale, M, Masci, AM, Fontana, S, and Zappacosta, S. "The role of CD4-Lck in T-cell receptor antagonism: evidence for negative signaling." Proc Natl Acad Sci U S A 93, no. 19 (September 17, 1996): 10360-10365. Link to Item
  - di Jeso, B, Ulianich, L, Racioppi, L, D'Armiento, F, Feliciello, A, Pacifico, F, Consiglio, E, and Formisano, S. "Serum withdrawal induces apoptotic cell death in Ki-ras transformed but not in normal differentiated thyroid cells." Biochem Biophys Res Commun 214, no. 3 (September 25, 1995): 819-824. Link to Item
  - Masci, AM, Scala, S, Racioppi, L, and Zappacosta, S. "Cell surface expression of major histocompatibility class I antigens is modulated by P-glycoprotein transporter." Human Immunology 42, no. 3 (March 1995): 245-253. Full Text
  - Racioppi, L, and Germain, RN. "Modified T-cell receptor ligands: moving beyond a strict occupancy model for T-cell activation by antigen." Chem Immunol 60 (1995): 79-99. (Review) Link to Item
  - "The Importance of Dominant Negative Effects of Amino Acid Side Chain Substitution in Peptide-MHC Molecule Interactions and T Cell Recognition." Journal of Immunology 150, no. 2 (December 1, 1993): 331341-null.
  - Di Rosa, F, D'Oro, U, Ruggiero, G, Racioppi, L, Acquaviva, A, Ferrone, S, Fontana, S, and Zappacosta, S. "HLA class II molecules transduce accessory signals affecting the CD3 but not the interleukin-2 activation pathway in T blasts." Hum Immunol 38, no. 4 (December 1993): 251-260. Link to Item
  - Racioppi, L, Ronchese, F, Matis, LA, and Germain, RN. "Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling." J Exp Med 177, no. 4 (April 1, 1993): 1047-1060. Link to Item
  - Boehncke, WH, Takeshita, T, Pendleton, CD, Houghten, RA, Sadegh-Nasseri, S, Racioppi, L, Berzofsky, JA, and Germain, RN. "The importance of dominant negative effects of amino acid side chain substitution in peptide-MHC molecule interactions and T cell recognition." J Immunol 150, no. 2 (January 15, 1993): 331-341. Link to Item
  - Racioppi, L, Ronchese, F, Schwartz, RH, and Germain, RN. "The molecular basis of class II MHC allelic control of T cell responses." Journal of Immunology (Baltimore, Md. : 1950) 147, no. 11 (December 1991): 3718-3727.
  - Carbone, E, Racioppi, L, La Cava, A, Portella, G, Velotti, F, Zappacosta, S, and Fontana, S. "NK and LAK susceptibility varies inversely with target cell MHC class I antigen expression in a rat epithelial tumour system." Scand J Immunol 33, no. 2 (February 1991): 185-194. Link to Item
  - Ruggiero, G, Racioppi, L, Manzo, C, Pirozzi, G, D'Oro, U, Ferrone, S, Zappacosta, S, and Fontana, S. "HLA class II molecules on monocytes regulate T cell proliferation through physical interaction in the CD3 activation pathway." European Journal of Immunology 21, no. 1 (January 1991): 29-33. Full Text
  - Racioppi, L, Moscarella, A, Ruggiero, G, Manzo, C, Ferrone, S, Fontana, S, and Zappacosta, S. "Inhibition by anti-HLA class II monoclonal antibodies of monoclonal antibody OKT3-induced T cell proliferation. Studies at the mRNA level." J Immunol 145, no. 11 (December 1, 1990): 3635-3640. Link to Item
  - Manzo, C, Ruggiero, G, del Vecchio, L, Racioppi, L, Pirozzi, G, Temponi, M, Ferrone, S, Fontana, S, and Zappacosta, S. "Monoclonal antibody OKT3-induced T cell proliferation: differential role of HLA class II determinants expressed by T cells and monocytes." Cell Immunol 125, no. 1 (January 1990): 79-91. Link to Item
  - Racioppi, L, Carbone, E, Grieco, M, Del Vecchio, L, Berlingieri, MT, Fusco, A, Boncinelli, E, Zappacosta, S, and Fontana, S. "The relationship of modulation of major histocompatibility complex class I antigens to retrovirus transformation in rat cell lines." Cancer Res 48, no. 13 (July 1, 1988): 3816-3821. Link to Item
  - Fontana, S, Del Vecchio, L, Racioppi, L, Carbone, E, Pinto, A, Colletta, G, and Zappacosta, S. "Expression of major histocompatibility complex class I antigens in normal and transformed rat thyroid epithelial cell lines." Cancer Res 47, no. 15 (August 1, 1987): 4178-4183. Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles