Current Duke Appointments & Affiliations
Associate Professor in Medicine
·
2021 - Present
Medicine, Hematologic Malignancies and Cellular Therapy,
Medicine
Member of the Duke Cancer Institute
·
2022 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Scholarly Works
CaMKK2: A tumor stress-integration node.
Journal article Trends Mol Med · July 1, 2026 Tumor progression depends on coordinated adaptation of cancer cells and the tumor microenvironment to immune pressure, metabolic limitations, genomic instability, and biomechanical stress. While these adaptive responses have often been investigated through ... Full text Link to item CiteCaMKK2 Regulates Macrophage Polarization Induced by Matrix Stiffness: Implications for Shaping the Immune Response in Stiffened Tissues.
Journal article Adv Sci (Weinh) · April 2025 Macrophages are essential for immune responses and maintaining tissue homeostasis, exhibiting a wide range of phenotypes depending on their microenvironment. The extracellular matrix (ECM) is a vital component that provides structural support and organizat ... Full text Link to item CiteEngineering biomaterials to tailor the microenvironment for macrophage–endothelium interactions
Journal article Nature Reviews Materials · October 1, 2023 Macrophages and endothelial cells (ECs) have essential roles in physiological and pathological conditions by regulating inflammation, vascularization and tissue remodelling. Although the interactions between macrophages and ECs in tissue homeostasis and di ... Full text CiteRecent Grants
Creating non-human tended microphysiological systems (CHIPS)
ResearchInvestigator · Awarded by Baylor College of Medicine · 2024 - 2027Artery-on-a-chip for preclinical evaluation of countermeasures against endothelial damage
ResearchCo Investigator · Awarded by The Trustees of Columbia University · 2024 - 2026Mechanisms of myeloid cells dysregulation in radiation survivors
ResearchPrincipal Investigator · Awarded by Columbia University · 2024 - 2026View All Grants
Education
University of Naples Federico II (Italy) ·
1992
Ph.D.
University of Naples Federico II (Italy) ·
1985
M.D.