Thymoma followed by paroxysmal nocturnal hemoglobinuria: a unique clinical association in the context of multiorgan autoimmunity with a potential role for CD8+ T lymphocytes.

Journal Article (Journal Article)

Seven years after a surgically resected thymoma, a female patient affected by myasthenia gravis and Good's syndrome presented with paroxysmal nocturnal hemoglobinuria (PNH). Co-culture experiments and spectratyping analyses indicated that CD8+ lymphocytes were involved in damaging hematopoietic precursors. While PNH clones have been identified in various hematological disorders, the sequential association of thymoma and PNH has been unreported so far.

Full Text

Duke Authors

Cited Authors

  • Palmieri, G; Selleri, C; Montella, L; Bulgarelli, G; Vitiello, L; Merkabaoui, G; Ricci, P; Del Vecchio, L; Masci, A; Racioppi, L; Rotoli, B

Published Date

  • October 2006

Published In

Volume / Issue

  • 81 / 10

Start / End Page

  • 774 - 778

PubMed ID

  • 16838334

International Standard Serial Number (ISSN)

  • 0361-8609

Digital Object Identifier (DOI)

  • 10.1002/ajh.20699


  • eng

Conference Location

  • United States