Autonomous programmable biomolecular devices using self-assembled DNA nanostructures

Journal Article (Review;Journal)

Recent developments in bio-DNA computer science techniques and methods for the development of autonomous programmable biomolecular devices based on self-assembled DNA nanostructures are reviewed. Molecular-scale devices using DNA nanostructures are engineered to have various capabilities such as execution of molecular-scale computation, use as scaffolds or templates for further assembly of other materials, and robotic movement and molecular transport. DNA nanostructures encode the Hamiltonian path after combining in a teat tube and cooling. Methods for autonomous execution of a sequence of finite-state operations are based on algorithmic self-assembly. Autonomous execution of a DNA sequence of finite-state transition is based on a linear DNA nanostructure whose sequence encodes the inputs and executes a series of steps that digest the DNA nanostructure from one end.

Full Text

Duke Authors

Cited Authors

  • Reif, JH; Labean, TH

Published Date

  • September 1, 2007

Published In

Volume / Issue

  • 50 / 9

Start / End Page

  • 46 - 53

Electronic International Standard Serial Number (EISSN)

  • 1557-7317

International Standard Serial Number (ISSN)

  • 0001-0782

Digital Object Identifier (DOI)

  • 10.1145/1284621.1284647

Citation Source

  • Scopus