Autonomous programmable biomolecular devices using self-assembled DNA nanostructures

Recent developments in bio-DNA computer science techniques and methods for the development of autonomous programmable biomolecular devices based on self-assembled DNA nanostructures are reviewed. Molecular-scale devices using DNA nanostructures are engineered to have various capabilities such as execution of molecular-scale computation, use as scaffolds or templates for further assembly of other materials, and robotic movement and molecular transport. DNA nanostructures encode the Hamiltonian path after combining in a teat tube and cooling. Methods for autonomous execution of a sequence of finite-state operations are based on algorithmic self-assembly. Autonomous execution of a DNA sequence of finite-state transition is based on a linear DNA nanostructure whose sequence encodes the inputs and executes a series of steps that digest the DNA nanostructure from one end.

Duke Scholars

Author John H. Reif Computer Science