Physiologic and cardiac roles of beta-arrestins.
Beta-arrestin1 and beta-arrestin2 were initially identified by sequence homology to visual arrestins and by their ability to bind to and inactivate signaling of the beta-2-adrenergic receptor in a process known as desensitization. While the role of beta-arrestins in desensitization has been known for some time, more recent evidence has revealed that beta-arrestins are multifunctional scaffolding proteins that are involved in numerous aspects of G protein-coupled receptor (GPCR) signaling. Interestingly, exciting new data shows that beta-arrestins can mediate signaling in their own right independent of classical second messenger mediated signaling, and that this beta-arrestin-mediated signaling may be cardioprotective. Identifying novel ligands for GPCRs that can block G protein-mediated signaling while simultaneously promoting beta-arrestin-mediated signaling could provide powerful new therapies for cardiac disease.
Duke Scholars
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- beta-Arrestins
- Second Messenger Systems
- Receptors, Adrenergic, beta-2
- Portraits as Topic
- Myocardium
- Humans
- Heart Diseases
- Cardiovascular System & Hematology
- Cardiotonic Agents
- Arrestins
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- beta-Arrestins
- Second Messenger Systems
- Receptors, Adrenergic, beta-2
- Portraits as Topic
- Myocardium
- Humans
- Heart Diseases
- Cardiovascular System & Hematology
- Cardiotonic Agents
- Arrestins