Cardiac hypertrophy: role of G protein-coupled receptors.

Journal Article (Journal Article)

Cardiac myocytes respond to biomechanical stress by initiating cellular processes that lead to hypertrophy. Although cardiac hypertrophy is a response to increased stress on the heart, it is also associated with elevated plasma catecholamine levels and an increase in cardiac morbidity and mortality. Understanding the cellular signals that initiate the hypertrophic response is of critical importance in identifying pathways that mediate the hypertrophic heart's maladaptive deterioration to cardiac failure. Here we present data demonstrating an important role for G protein-coupled receptors in the induction of in vivo cardiac hypertrophy and the activation of signaling pathways, such as the mitogen activated protein kinase and phosphoinositide-3 kinase pathways.

Full Text

Duke Authors

Cited Authors

  • Esposito, G; Rapacciuolo, A; Naga Prasad, SV; Rockman, HA

Published Date

  • December 2002

Published In

Volume / Issue

  • 8 / 6 Suppl

Start / End Page

  • S409 - S414

PubMed ID

  • 12555153

International Standard Serial Number (ISSN)

  • 1071-9164

Digital Object Identifier (DOI)

  • 10.1054/jcaf.2002.129283


  • eng

Conference Location

  • United States