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Disrupting nicotine reinforcement: from cigarette to brain.

Publication ,  Journal Article
Rose, JE
Published in: Ann N Y Acad Sci
October 2008

Cigarette smoking is a tenacious addiction that is maintained to a significant extent by the reinforcing effects of nicotine. An emerging theme in smoking cessation treatment is the development of methods for interfering with these reinforcing effects. By attenuating nicotine reinforcement, treatments may enhance a smoker's chances of successfully remaining abstinent. Several treatment approaches will be described, including the use of denicotinized cigarettes, nicotine vaccines, nicotinic receptor agonists and antagonists, and modulators of brain reinforcement processes. These techniques highlight the numerous sites along the path between the cigarette and the brain that can be targeted for intervention. In addition to unimodal therapies, treatment combinations will be discussed that might more effectively block cigarette reward and thereby further enhance smoking abstinence.

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Published In

Ann N Y Acad Sci

DOI

EISSN

1749-6632

Publication Date

October 2008

Volume

1141

Start / End Page

233 / 256

Location

United States

Related Subject Headings

  • Tobacco Use Disorder
  • Substance Withdrawal Syndrome
  • Smoking Cessation
  • Smoking
  • Smoke
  • Sensation
  • Reward
  • Respiratory System
  • Reinforcement, Psychology
  • Receptors, Nicotinic
 

Citation

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Rose, J. E. (2008). Disrupting nicotine reinforcement: from cigarette to brain. Ann N Y Acad Sci, 1141, 233–256. https://doi.org/10.1196/annals.1441.019
Rose, Jed E. “Disrupting nicotine reinforcement: from cigarette to brain.Ann N Y Acad Sci 1141 (October 2008): 233–56. https://doi.org/10.1196/annals.1441.019.
Rose JE. Disrupting nicotine reinforcement: from cigarette to brain. Ann N Y Acad Sci. 2008 Oct;1141:233–56.
Rose, Jed E. “Disrupting nicotine reinforcement: from cigarette to brain.Ann N Y Acad Sci, vol. 1141, Oct. 2008, pp. 233–56. Pubmed, doi:10.1196/annals.1441.019.
Rose JE. Disrupting nicotine reinforcement: from cigarette to brain. Ann N Y Acad Sci. 2008 Oct;1141:233–256.
Journal cover image

Published In

Ann N Y Acad Sci

DOI

EISSN

1749-6632

Publication Date

October 2008

Volume

1141

Start / End Page

233 / 256

Location

United States

Related Subject Headings

  • Tobacco Use Disorder
  • Substance Withdrawal Syndrome
  • Smoking Cessation
  • Smoking
  • Smoke
  • Sensation
  • Reward
  • Respiratory System
  • Reinforcement, Psychology
  • Receptors, Nicotinic