Disrupting nicotine reinforcement: from cigarette to brain.

Journal Article (Journal Article;Review)

Cigarette smoking is a tenacious addiction that is maintained to a significant extent by the reinforcing effects of nicotine. An emerging theme in smoking cessation treatment is the development of methods for interfering with these reinforcing effects. By attenuating nicotine reinforcement, treatments may enhance a smoker's chances of successfully remaining abstinent. Several treatment approaches will be described, including the use of denicotinized cigarettes, nicotine vaccines, nicotinic receptor agonists and antagonists, and modulators of brain reinforcement processes. These techniques highlight the numerous sites along the path between the cigarette and the brain that can be targeted for intervention. In addition to unimodal therapies, treatment combinations will be discussed that might more effectively block cigarette reward and thereby further enhance smoking abstinence.

Full Text

Duke Authors

Cited Authors

  • Rose, JE

Published Date

  • October 2008

Published In

Volume / Issue

  • 1141 /

Start / End Page

  • 233 - 256

PubMed ID

  • 18991961

Electronic International Standard Serial Number (EISSN)

  • 1749-6632

Digital Object Identifier (DOI)

  • 10.1196/annals.1441.019


  • eng

Conference Location

  • United States