Regulation of the postsynaptic cytoskeleton: roles in development, plasticity, and disorders.

Journal Article (Journal Article;Review)

The small size of dendritic spines belies the elaborate role they play in excitatory synaptic transmission and ultimately complex behaviors. The cytoskeletal architecture of the spine is predominately composed of actin filaments. These filaments, which at first glance might appear simple, are also surprisingly complex. They dynamically assemble into different structures and serve as a platform for orchestrating the elaborate responses of the spine during experience-dependent plasticity. This mini-symposium review will feature ongoing research into how spines are regulated by actin-signaling pathways during development and plasticity. It will also highlight evolving studies into how disruptions to these pathways might be functionally coupled to congenital disorders such as mental retardation.

Full Text

Duke Authors

Cited Authors

  • Svitkina, T; Lin, W-H; Webb, DJ; Yasuda, R; Wayman, GA; Van Aelst, L; Soderling, SH

Published Date

  • November 10, 2010

Published In

Volume / Issue

  • 30 / 45

Start / End Page

  • 14937 - 14942

PubMed ID

  • 21068295

Pubmed Central ID

  • PMC3074493

Electronic International Standard Serial Number (EISSN)

  • 1529-2401

Digital Object Identifier (DOI)

  • 10.1523/JNEUROSCI.4276-10.2010


  • eng

Conference Location

  • United States