Skip to main content

Scott Haydn Soderling

George Barth Geller Distinguished Professor of Molecular Biology
Cell Biology
Duke Box 3709, Durham, NC 27710
Nanaline Duke Bldg, Durham, NC 27710

Current Appointments & Affiliations


George Barth Geller Distinguished Professor of Molecular Biology · 2020 - Present Cell Biology, Basic Science Departments
Professor in Cell Biology · 2017 - Present Cell Biology, Basic Science Departments
Chair, Department of Cell Biology · 2019 - Present Cell Biology, Basic Science Departments
Professor of Neurobiology · 2017 - Present Neurobiology, Basic Science Departments
Member of the Duke Cancer Institute · 2005 - Present Duke Cancer Institute, Institutes and Centers
Faculty Network Member of the Duke Institute for Brain Sciences · 2011 - Present Duke Institute for Brain Sciences, University Institutes and Centers

In the News


Published March 4, 2024
Three Universities Team up on Disease Prevention
Published November 12, 2020
Astrocytes Identified as Master ‘Conductors’ of the Brain
Published April 14, 2020
Duke Awards 29 University Distinguished Professorships

View All News

Recent Publications


De novo design of peptide binders to conformationally diverse targets with contrastive language modeling.

Journal Article Sci Adv · January 24, 2025 Designing binders to target undruggable proteins presents a formidable challenge in drug discovery. In this work, we provide an algorithmic framework to design short, target-binding linear peptides, requiring only the amino acid sequence of the target prot ... Full text Link to item Cite

The Epilepsy-Aphasia Syndrome gene, Cnksr2, Plays a Critical Role in the Anterior Cingulate Cortex Mediating Vocal Communication.

Journal Article eNeuro · December 18, 2024 Epilepsy Aphasia Syndrome (EAS) is a spectrum of childhood disorders that exhibit complex co-morbidities that include epilepsy and the emergence of cognitive and language disorders. CNKSR2 is an X-linked gene in which mutations are linked to EAS. We previo ... Full text Link to item Cite

Proximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions.

Journal Article Nat Commun · August 9, 2024 One of the main drivers of autism spectrum disorder is risk alleles within hundreds of genes, which may interact within shared but unknown protein complexes. Here we develop a scalable genome-editing-mediated approach to target 14 high-confidence autism ri ... Full text Link to item Cite
View All Publications

Recent Grants


Soderling Mentorship

ResearchPrincipal Investigator · Awarded by Chan Zuckerberg Initiative · 2024 - 2029

Neurobiology Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institute of Neurological Disorders and Stroke · 2024 - 2029

Duke-NCCU Interdisciplinary Postdoctoral Training Program in Child Psychiatric and Neurodevelopmental Conditions Program (DN-IPT)

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2024 - 2029

View All Grants

Education, Training & Certifications


University of Washington · 1999 Ph.D.