Current Appointments & Affiliations
George Barth Geller Distinguished Professor of Molecular Biology
·
2020 - Present
Cell Biology,
Basic Science Departments
Professor in Cell Biology
·
2017 - Present
Cell Biology,
Basic Science Departments
Chair, Department of Cell Biology
·
2019 - Present
Cell Biology,
Basic Science Departments
Professor of Neurobiology
·
2017 - Present
Neurobiology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2005 - Present
Duke Cancer Institute,
Institutes and Centers
Faculty Network Member of the Duke Institute for Brain Sciences
·
2011 - Present
Duke Institute for Brain Sciences,
University Institutes and Centers
Recent Publications
De novo design of peptide binders to conformationally diverse targets with contrastive language modeling.
Journal Article Sci Adv · January 24, 2025 Designing binders to target undruggable proteins presents a formidable challenge in drug discovery. In this work, we provide an algorithmic framework to design short, target-binding linear peptides, requiring only the amino acid sequence of the target prot ... Full text Link to item CiteThe Epilepsy-Aphasia Syndrome gene, Cnksr2, Plays a Critical Role in the Anterior Cingulate Cortex Mediating Vocal Communication.
Journal Article eNeuro · December 18, 2024 Epilepsy Aphasia Syndrome (EAS) is a spectrum of childhood disorders that exhibit complex co-morbidities that include epilepsy and the emergence of cognitive and language disorders. CNKSR2 is an X-linked gene in which mutations are linked to EAS. We previo ... Full text Link to item CiteProximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions.
Journal Article Nat Commun · August 9, 2024 One of the main drivers of autism spectrum disorder is risk alleles within hundreds of genes, which may interact within shared but unknown protein complexes. Here we develop a scalable genome-editing-mediated approach to target 14 high-confidence autism ri ... Full text Link to item CiteRecent Grants
Soderling Mentorship
ResearchPrincipal Investigator · Awarded by Chan Zuckerberg Initiative · 2024 - 2029Neurobiology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of Neurological Disorders and Stroke · 2024 - 2029Duke-NCCU Interdisciplinary Postdoctoral Training Program in Child Psychiatric and Neurodevelopmental Conditions Program (DN-IPT)
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2024 - 2029View All Grants
Education, Training & Certifications
University of Washington ·
1999
Ph.D.