Scott Haydn Soderling | Scholars@Duke

Scott Haydn Soderling
George Barth Geller Distinguished Professor of Molecular Biology

Current Appointments & Affiliations

George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology, Basic Science Departments 2020
Professor in Cell Biology, Cell Biology, Basic Science Departments 2017
Chair, Department of Cell Biology, Cell Biology, Basic Science Departments 2019
Professor of Neurobiology, Neurobiology, Basic Science Departments 2021
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2005
Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2011

Contact Information

Duke Box 3709, Durham, NC 27710
Nanaline Duke Bldg, Durham, NC 27710
s.soderling@cellbio.duke.edu (919) 684-8085
Department of Cell Biology
Lab page

Background
Education, Training, & Certifications
- Postdoctoral Fellow, Hhmi, Oregon Health and Science University 1999 - 2005
- Ph.D., University of Washington 1999
Previous Appointments & Affiliations
- Interim Chair, Department of Cell Biology, Cell Biology, Basic Science Departments 2018 - 2019
- Vice Chair of the Department of Cell Biology, Cell Biology, Basic Science Departments 2018
- Associate Professor in Cell Biology, Cell Biology, Basic Science Departments 2013 - 2017
- Associate Professor of Neurobiology, Neurobiology, Basic Science Departments 2013 - 2017
- Assistant Professor in Cell Biology, Cell Biology, Basic Science Departments 2005 - 2013
- Assistant Professor of Neurobiology, Neurobiology, Basic Science Departments 2007 - 2013
Recognition
In the News
- NOV 12, 2020
  
  Astrocytes Identified as Master ‘Conductors’ of the Brain
- APR 14, 2020
  
  Duke Awards 29 University Distinguished Professorships
- JUN 26, 2015
  
  Allen Song Named Interim Director of Brain Institute
- MAY 5, 2015 Los Angeles Times
  
  Schizophrenia's secrets begin to unravel
- MAY 1, 2015
  
  Scientists Reconcile Three Unrelated Theories of Schizophrenia
- JAN 6, 2015
  
  Study Pinpoints Autism-Linked Protein for Sculpting Brain Connections
Expertise
Subject Headings
Research
Selected Grants
- Molecular Analysis of Developmental Brain Disorders Associated with Synaptic Pathology awarded by National Institutes of Health 2022 - 2027
- Medical Scientist Training Program awarded by National Institutes of Health 2022 - 2027
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2027
- Linking Neuron-Astrocyte Communication to Long-Term Changes in Neural Circuit Function and Behavior awarded by Salk Institute Biotechnology/Industrial Associatio 2021 - 2026
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Proteomic and Functional Analysis of Presynaptic Physiology and Plasticity awarded by National Institutes of Health 2021 - 2026
- Multi-omics functional analysis of non-coding regulatory genome for genomic medicine awarded by National Institutes of Health 2020 - 2025
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- Investigating the role of RNP granules during heart regeneration in the zebrafish awarded by American Heart Association 2022 - 2025
- CIRCUIT MECHANISMS FOR DOPAMINE NEURON VULNERABILITY AND RESILIENCE IN PD awarded by Michael J. Fox Foundation for Parkinson's Research 2021 - 2024
- Neurobiology Training Program awarded by National Institutes of Health 2019 - 2024
- Identifying Endogenous Proteomes and Polygenic Dysregulations Associated with Synaptic Schizophrenia Risk Genes awarded by Brain and Behavior Research Foundation 2022 - 2024
- HHMI Hanna H. Gray Fellows Program: Mitochondrial surveillance in neuronal homeostasis and disease awarded by Howard Hughes Medical Institute 2021 - 2023
- Epitranscriptomic Regulation of Synaptic Responses to Drugs of Abuse awarded by National Institutes of Health 2018 - 2023
- Duke CTSA (TL1) Year 5 awarded by National Institutes of Health 2018 - 2023
- Analysis of Inhibitory Synaptic Proteins Associated with Brain Disorders awarded by National Institutes of Health 2017 - 2023
- Phospho-regulation as a driver of inhibitory synapse function awarded by National Institutes of Health 2021 - 2022
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Zeiss Lightsheet Upgrade to Expand Imaging Capabilities awarded by National Institutes of Health 2021 - 2022
- Control of Astrocyte Morphogenesis and Synaptogenesis by Astrocytic Neuroligins awarded by National Institutes of Health 2019 - 2022
- Interneuron Synapses: In Vivo Chemicogenetic Proteomics to Discover Developmental Brain Disorder Etiologies awarded by National Institutes of Health 2019 - 2022
- New Proteomic and Genome Engineering Approaches to Decipher Astrocyte Function at Synapses awarded by National Institutes of Health 2018 - 2021
- Super-resolution Imaging via Multiple Modalities with the Zeiss Elyra 7 awarded by National Institutes of Health 2020 - 2021
- Interrogating the role of the novel synaptic protein Rogdi in GABAergic inhibition and epilepsy awarded by National Institutes of Health 2019 - 2021
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- How Does Huntingtin Control Synaptic Development? awarded by National Institutes of Health 2018 - 2020
- Molecular, Synaptic, and Circuit Basis for Schizophrenia-related Phenotypes awarded by National Institutes of Health 2014 - 2020
- Thermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass Spectrometer awarded by National Institutes of Health 2018 - 2019
- Chemico-genetic analysis of serotonergic circuits and synapses awarded by Ruth K. Broad Biomedical Research Foundation 2018 - 2019
- Control of cell fate by progenitor mitosis length and microcephaly-linked genes during cortical development awarded by National Institutes of Health 2017 - 2019
- Unveiling Brain Circuits of Abnormal Social Behavior awarded by Brain and Behavior Research Foundation 2017 - 2019
- Basic predoctoral training in neuroscience awarded by National Institutes of Health 1992 - 2018
- Fragile X Phenotypes Modulated by Altered Signaling to the Synaptic Cytoskeleton awarded by National Institutes of Health 2014 - 2018
- Analysis of Arp2/3 activity as a major driver of dendritic spinogenesis awarded by National Institutes of Health 2015 - 2018
- Quantitative Analysis of the Postsynaptic Inhibitory Complex In Vivo awarded by National Institutes of Health 2015 - 2017
- Synaptic plasticity awarded by Max Planck Institute 2013 - 2016
- Training in Fundamental &Translational Neuroscience awarded by National Institutes of Health 2005 - 2016
- Agilent Direct Drive 9.4T MRS/MRI Console awarded by National Institutes of Health 2012 - 2013
- The effects of Nlrp12 and IL-1b in inflammatory disorders awarded by National Institutes of Health 2010 - 2012
- Mapping the Architecture of Cancer Signaling Pathways awarded by National Institutes of Health 2009 - 2012
External Relationships
- CasTag Biosciences
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Takano, Tetsuya, and Scott H. Soderling. “Tripartite synaptomics: Cell-surface proximity labeling in vivo.” Neurosci Res 173 (December 2021): 14–21. https://doi.org/10.1016/j.neures.2021.05.002.
    Full Text Link to Item
  - Erata, Eda, Yudong Gao, Alicia M. Purkey, Erik J. Soderblom, James O. McNamara, and Scott H. Soderling. “Cnksr2 Loss in Mice Leads to Increased Neural Activity and Behavioral Phenotypes of Epilepsy-Aphasia Syndrome.” J Neurosci 41, no. 46 (November 17, 2021): 9633–49. https://doi.org/10.1523/JNEUROSCI.0650-21.2021.
    Full Text Link to Item
  - O’Neil, Shataakshi Dube, Bence Rácz, Walter Evan Brown, Yudong Gao, Erik J. Soderblom, Ryohei Yasuda, and Scott H. Soderling. “Action potential-coupled Rho GTPase signaling drives presynaptic plasticity.” Elife 10 (July 16, 2021). https://doi.org/10.7554/eLife.63756.
    Full Text Link to Item
  - Courtland, Jamie L., Tyler Wa Bradshaw, Greg Waitt, Erik J. Soderblom, Tricia Ho, Anna Rajab, Ricardo Vancini, Il Hwan Kim, and Scott H. Soderling. “Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans.” Elife 10 (March 22, 2021). https://doi.org/10.7554/eLife.61590.
    Full Text Open Access Copy Link to Item
  - Takano, Tetsuya, John T. Wallace, Katherine T. Baldwin, Alicia M. Purkey, Akiyoshi Uezu, Jamie L. Courtland, Erik J. Soderblom, et al. “Chemico-genetic discovery of astrocytic control of inhibition in vivo.” Nature 588, no. 7837 (December 2020): 296–302. https://doi.org/10.1038/s41586-020-2926-0.
    Full Text Link to Item
  - Black, Joshua B., Sean R. McCutcheon, Shataakshi Dube, Alejandro Barrera, Tyler S. Klann, Grayson A. Rice, Shaunak S. Adkar, Scott H. Soderling, Timothy E. Reddy, and Charles A. Gersbach. “Master Regulators and Cofactors of Human Neuronal Cell Fate Specification Identified by CRISPR Gene Activation Screens.” Cell Rep 33, no. 9 (December 1, 2020): 108460. https://doi.org/10.1016/j.celrep.2020.108460.
    Full Text Link to Item
  - Kim, Il Hwan, Namsoo Kim, Sunwhi Kim, Koji Toda, Christina M. Catavero, Jamie L. Courtland, Henry H. Yin, and Scott H. Soderling. “Dysregulation of the Synaptic Cytoskeleton in the PFC Drives Neural Circuit Pathology, Leading to Social Dysfunction.” Cell Rep 32, no. 4 (July 28, 2020): 107965. https://doi.org/10.1016/j.celrep.2020.107965.
    Full Text Link to Item
  - Uezu, Akiyoshi, Erin Hisey, Yoshihiko Kobayashi, Yudong Gao, Tyler Wa Bradshaw, Patrick Devlin, Ramona Rodriguiz, Purushothama Rao Tata, and Scott Soderling. “Essential role for InSyn1 in dystroglycan complex integrity and cognitive behaviors in mice.” Elife 8 (December 12, 2019). https://doi.org/10.7554/eLife.50712.
    Full Text Link to Item
  - Gao, Yudong, Erin Hisey, Tyler W. A. Bradshaw, Eda Erata, Walter E. Brown, Jamie L. Courtland, Akiyoshi Uezu, Yu Xiang, Yarui Diao, and Scott H. Soderling. “Plug-and-Play Protein Modification Using Homology-Independent Universal Genome Engineering.” Neuron 103, no. 4 (August 21, 2019): 583-597.e8. https://doi.org/10.1016/j.neuron.2019.05.047.
    Full Text Link to Item
  - Kinoshita, Nagatoki, Arthur J. Y. Huang, Thomas J. McHugh, Sachihiro C. Suzuki, Ichiro Masai, Il Hwan Kim, Scott H. Soderling, Atsushi Miyawaki, and Tomomi Shimogori. “Genetically Encoded Fluorescent Indicator GRAPHIC Delineates Intercellular Connections.” Iscience 15 (May 31, 2019): 28–38. https://doi.org/10.1016/j.isci.2019.04.013.
    Full Text Link to Item
  - Spence, Erin F., Shataakshi Dube, Akiyoshi Uezu, Margaret Locke, Erik J. Soderblom, and Scott H. Soderling. “In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation.” Nat Commun 10, no. 1 (January 23, 2019): 386. https://doi.org/10.1038/s41467-019-08288-w.
    Full Text Link to Item
  - Risher, W Christopher, Namsoo Kim, Sehwon Koh, Ji-Eun Choi, Petar Mitev, Erin F. Spence, Louis-Jan Pilaz, et al. “Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1.” J Cell Biol 217, no. 10 (October 1, 2018): 3747–65. https://doi.org/10.1083/jcb.201802057.
    Full Text Link to Item
  - Newpher, Thomas M., Scott Harris, Jasmine Pringle, Colleen Hamilton, and Scott Soderling. “Regulation of spine structural plasticity by Arc/Arg3.1.” Semin Cell Dev Biol 77 (May 2018): 25–32. https://doi.org/10.1016/j.semcdb.2017.09.022.
    Full Text Open Access Copy Link to Item
  - Chen, Yuxiao, Marija Milenkovic, Wendy Horsfall, Ali Salahpour, Scott H. Soderling, and Amy J. Ramsey. “Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown mice.” Plos One 13, no. 10 (2018): e0199341. https://doi.org/10.1371/journal.pone.0199341.
    Full Text Link to Item
  - Spence, Erin F., Daniel J. Kanak, Benjamin R. Carlson, and Scott H. Soderling. “The Arp2/3 Complex Is Essential for Distinct Stages of Spine Synapse Maturation, Including Synapse Unsilencing.” J Neurosci 36, no. 37 (September 14, 2016): 9696–9709. https://doi.org/10.1523/JNEUROSCI.0876-16.2016.
    Full Text Link to Item
  - Uezu, Akiyoshi, Daniel J. Kanak, Tyler W. A. Bradshaw, Erik J. Soderblom, Christina M. Catavero, Alain C. Burette, Richard J. Weinberg, and Scott H. Soderling. “Identification of an elaborate complex mediating postsynaptic inhibition.” Science 353, no. 6304 (September 9, 2016): 1123–29. https://doi.org/10.1126/science.aag0821.
    Full Text Link to Item
  - Rossi, Mark A., Haofang E. Li, Dongye Lu, Il Hwan Kim, Ryan A. Bartholomew, Erin Gaidis, Joseph W. Barter, et al. “A GABAergic nigrotectal pathway for coordination of drinking behavior.” Nat Neurosci 19, no. 5 (May 2016): 742–48. https://doi.org/10.1038/nn.4285.
    Full Text Link to Item
  - Singh, Sandeep K., Jeff A. Stogsdill, Nisha S. Pulimood, Hayley Dingsdale, Yong Ho Kim, Louis-Jan Pilaz, Il Hwan Kim, et al. “Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin.” Cell 164, no. 1–2 (January 14, 2016): 183–96. https://doi.org/10.1016/j.cell.2015.11.034.
    Full Text Link to Item
  - Spence, Erin F., and Scott H. Soderling. “Actin Out: Regulation of the Synaptic Cytoskeleton.” J Biol Chem 290, no. 48 (November 27, 2015): 28613–22. https://doi.org/10.1074/jbc.R115.655118.
    Full Text Link to Item
  - Zuchero, J. B., M. M. Fu, S. A. Sloan, A. Ibrahim, A. Olson, A. Zaremba, J. C. Dugas, et al. “CNS Myelin Wrapping Is Driven by Actin Disassembly [Developmental Cell 34, 152-167; 27 July 2015].” Developmental Cell 34, no. 5 (September 14, 2015): 608. https://doi.org/10.1016/j.devcel.2015.08.013.
    Full Text
  - Zuchero, J Bradley, Meng-Meng Fu, Steven A. Sloan, Adiljan Ibrahim, Andrew Olson, Anita Zaremba, Jason C. Dugas, et al. “CNS myelin wrapping is driven by actin disassembly.” Dev Cell 34, no. 2 (July 27, 2015): 152–67. https://doi.org/10.1016/j.devcel.2015.06.011.
    Full Text Link to Item
  - Kim, Il Hwan, Mark A. Rossi, Dipendra K. Aryal, Bence Racz, Namsoo Kim, Akiyoshi Uezu, Fan Wang, et al. “Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine.” Nat Neurosci 18, no. 6 (June 2015): 883–91. https://doi.org/10.1038/nn.4015.
    Full Text Link to Item
  - Risher, W Christopher, Sagar Patel, Il Hwan Kim, Akiyoshi Uezu, Srishti Bhagat, Daniel K. Wilton, Louis-Jan Pilaz, et al. “Astrocytes refine cortical connectivity at dendritic spines.” Elife 3 (December 17, 2014). https://doi.org/10.7554/eLife.04047.
    Full Text Open Access Copy Link to Item
  - Kim, Il Hwan, Hong Wang, Scott H. Soderling, and Ryohei Yasuda. “Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall.” Elife 3 (July 8, 2014). https://doi.org/10.7554/eLife.02839.
    Full Text Link to Item
  - Kim, Il Hwan, Hong Wang, Scott H. Soderling, and Ryohei Yasuda. “Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall.” Elife 3 (2014). https://doi.org/10.7554/eLife.02839.
    Full Text Link to Item
  - Zhou, Kang, Andrew Muroyama, Julie Underwood, Rebecca Leylek, Samriddha Ray, Scott H. Soderling, and Terry Lechler. “Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation.” Proc Natl Acad Sci U S A 110, no. 40 (October 1, 2013): E3820–29. https://doi.org/10.1073/pnas.1308419110.
    Full Text Link to Item
  - Kim, Il Hwan, Bence Racz, Hong Wang, Lauren Burianek, Richard Weinberg, Ryohei Yasuda, William C. Wetsel, and Scott H. Soderling. “Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities.” J Neurosci 33, no. 14 (April 3, 2013): 6081–92. https://doi.org/10.1523/JNEUROSCI.0035-13.2013.
    Full Text Link to Item
  - Burianek, Lauren E., and Scott H. Soderling. “Under lock and key: spatiotemporal regulation of WASP family proteins coordinates separate dynamic cellular processes.” Semin Cell Dev Biol 24, no. 4 (April 2013): 258–66. https://doi.org/10.1016/j.semcdb.2012.12.005.
    Full Text Link to Item
  - Hazai, Diána, Róbert Szudoczki, Jindong Ding, Scott H. Soderling, Richard J. Weinberg, Péter Sótonyi, and Bence Rácz. “Ultrastructural abnormalities in CA1 hippocampus caused by deletion of the actin regulator WAVE-1.” Plos One 8, no. 9 (2013): e75248. https://doi.org/10.1371/journal.pone.0075248.
    Full Text Link to Item
  - Kim, Il Hwan, Benjamin R. Carlson, Clifford C. Heindel, Hyun Kim, and Scott H. Soderling. “Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus.” J Biol Chem 287, no. 46 (November 9, 2012): 39263–74. https://doi.org/10.1074/jbc.M112.398834.
    Full Text Link to Item
  - Uezu, Akiyoshi, Hirokazu Okada, Hideji Murakoshi, Cosmo D. del Vescovo, Ryohei Yasuda, Dario Diviani, and Scott H. Soderling. “Modified SH2 domain to phototrap and identify phosphotyrosine proteins from subcellular sites within cells.” Proc Natl Acad Sci U S A 109, no. 43 (October 23, 2012): E2929–38. https://doi.org/10.1073/pnas.1207358109.
    Full Text Link to Item
  - Okada, Hirokazu, Akiyoshi Uezu, Erik J. Soderblom, M Arthur Moseley, Frank B. Gertler, and Scott H. Soderling. “Peptide array X-linking (PAX): a new peptide-protein identification approach.” Plos One 7, no. 5 (2012): e37035. https://doi.org/10.1371/journal.pone.0037035.
    Full Text Link to Item
  - Okada, Hirokazu, Akiyoshi Uezu, Frank M. Mason, Erik J. Soderblom, M Arthur Moseley, and Scott H. Soderling. “SH3 domain-based phototrapping in living cells reveals Rho family GAP signaling complexes.” Sci Signal 4, no. 201 (November 29, 2011): rs13. https://doi.org/10.1126/scisignal.2002189.
    Full Text Link to Item
  - Mason, Frank M., Ernest G. Heimsath, Henry N. Higgs, and Scott H. Soderling. “Bi-modal regulation of a formin by srGAP2.” J Biol Chem 286, no. 8 (February 25, 2011): 6577–86. https://doi.org/10.1074/jbc.M110.190397.
    Full Text Link to Item
  - Carlson, Benjamin R., Krissey E. Lloyd, Allison Kruszewski, Il-Hwan Kim, Ramona M. Rodriguiz, Clifford Heindel, Marika Faytell, Serena M. Dudek, William C. Wetsel, and Scott H. Soderling. “WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory.” J Neurosci 31, no. 7 (February 16, 2011): 2447–60. https://doi.org/10.1523/JNEUROSCI.4433-10.2011.
    Full Text Link to Item
  - Mason, F. M., and S. H. Soderling. “WASP and WAVE family protein complexes” 2 (December 1, 2010): 1265–70. https://doi.org/10.1016/B978-0-12-374145-5.00157-1.
    Full Text
  - Svitkina, Tatyana, Wan-Hsin Lin, Donna J. Webb, Ryohei Yasuda, Gary A. Wayman, Linda Van Aelst, and Scott H. Soderling. “Regulation of the postsynaptic cytoskeleton: roles in development, plasticity, and disorders.” J Neurosci 30, no. 45 (November 10, 2010): 14937–42. https://doi.org/10.1523/JNEUROSCI.4276-10.2010.
    Full Text Link to Item
  - Kim, Il Hwan, Soon Kwon Park, Soon Taek Hong, Yong Sang Jo, Eun Joo Kim, Eun Hye Park, Seung Baek Han, et al. “Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for synaptic Rac signaling.” J Neurosci 29, no. 44 (November 4, 2009): 14039–49. https://doi.org/10.1523/JNEUROSCI.2483-09.2009.
    Full Text Link to Item
  - Carlson, Benjamin, and Scott H. Soderling. “Mechanisms of cellular protrusions branch out.” Dev Cell 17, no. 3 (September 2009): 307–9. https://doi.org/10.1016/j.devcel.2009.08.015.
    Full Text Link to Item
  - Soderling, Scott H. “Grab your partner with both hands: cytoskeletal remodeling by Arp2/3 signaling.” Sci Signal 2, no. 55 (January 27, 2009): pe5. https://doi.org/10.1126/scisignal.255pe5.
    Full Text Link to Item
  - Soderling, Scott H., Eric S. Guire, Stefanie Kaech, Jon White, Fang Zhang, Kevin Schutz, Lorene K. Langeberg, Gary Banker, Jacob Raber, and John D. Scott. “A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory.” J Neurosci 27, no. 2 (January 10, 2007): 355–65. https://doi.org/10.1523/JNEUROSCI.3209-06.2006.
    Full Text Link to Item
  - Soderling, S. H., and J. D. Scott. “WAVE signalling: from biochemistry to biology.” Biochem Soc Trans 34, no. Pt 1 (February 2006): 73–76. https://doi.org/10.1042/BST0340073.
    Full Text Link to Item
  - Vasta, Valeria, William K. Sonnenburg, Chen Yan, Scott H. Soderling, Masami Shimizu-Albergine, and Joseph A. Beavo. “Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm.” Biol Reprod 73, no. 4 (October 2005): 598–609. https://doi.org/10.1095/biolreprod.104.039180.
    Full Text Link to Item
  - Alto, Neal M., Scott H. Soderling, Naoto Hoshi, Lorene K. Langeberg, Rosa Fayos, Patricia A. Jennings, and John D. Scott. “Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring.” Proc Natl Acad Sci U S A 100, no. 8 (April 15, 2003): 4445–50. https://doi.org/10.1073/pnas.0330734100.
    Full Text Link to Item
  - Soderling, Scott H., Lorene K. Langeberg, Jacquelyn A. Soderling, Stephen M. Davee, Richard Simerly, Jacob Raber, and John D. Scott. “Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice.” Proc Natl Acad Sci U S A 100, no. 4 (February 18, 2003): 1723–28. https://doi.org/10.1073/pnas.0438033100.
    Full Text Link to Item
  - Soderling, Scott H., Kathleen L. Binns, Gary A. Wayman, Stephen M. Davee, Siew Hwa Ong, Tony Pawson, and John D. Scott. “The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling.” Nat Cell Biol 4, no. 12 (December 2002): 970–75. https://doi.org/10.1038/ncb886.
    Full Text Link to Item
  - Rascón, Ana, Scott H. Soderling, Jonathan B. Schaefer, and Joseph A. Beavo. “Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei.” Proc Natl Acad Sci U S A 99, no. 7 (April 2, 2002): 4714–19. https://doi.org/10.1073/pnas.002031599.
    Full Text Link to Item
  - Hetman, J. M., N. Robas, R. Baxendale, M. Fidock, S. C. Phillips, S. H. Soderling, and J. A. Beavo. “Cloning and characterization of two splice variants of human phosphodiesterase 11A.” Proc Natl Acad Sci U S A 97, no. 23 (November 7, 2000): 12891–95. https://doi.org/10.1073/pnas.200355397.
    Full Text Link to Item
  - Westphal, R. S., S. H. Soderling, N. M. Alto, L. K. Langeberg, and J. D. Scott. “Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold.” Embo J 19, no. 17 (September 1, 2000): 4589–4600. https://doi.org/10.1093/emboj/19.17.4589.
    Full Text Link to Item
  - Soderling, S. H., and J. A. Beavo. “Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions.” Curr Opin Cell Biol 12, no. 2 (April 2000): 174–79. https://doi.org/10.1016/s0955-0674(99)00073-3.
    Full Text Link to Item
  - Fawcett, L., R. Baxendale, P. Stacey, C. McGrouther, I. Harrow, S. Soderling, J. Hetman, J. A. Beavo, and S. C. Phillips. “Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A.” Proc Natl Acad Sci U S A 97, no. 7 (March 28, 2000): 3702–7. https://doi.org/10.1073/pnas.97.7.3702.
    Full Text Link to Item
  - Hetman, J. M., S. H. Soderling, N. A. Glavas, and J. A. Beavo. “Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase.” Proc Natl Acad Sci U S A 97, no. 1 (January 4, 2000): 472–76. https://doi.org/10.1073/pnas.97.1.472.
    Full Text Link to Item
  - Soderling, S. H., S. J. Bayuga, and J. A. Beavo. “Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A.” Proc Natl Acad Sci U S A 96, no. 12 (June 8, 1999): 7071–76. https://doi.org/10.1073/pnas.96.12.7071.
    Full Text Link to Item
  - Juilfs, D. M., S. Soderling, F. Burns, and J. A. Beavo. “Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs).” Rev Physiol Biochem Pharmacol 135 (1999): 67–104. https://doi.org/10.1007/BFb0033670.
    Full Text Link to Item
  - Soderling, S. H., S. J. Bayuga, and J. A. Beavo. “Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase.” Proc Natl Acad Sci U S A 95, no. 15 (July 21, 1998): 8991–96. https://doi.org/10.1073/pnas.95.15.8991.
    Full Text Link to Item
  - Soderling, S. H., S. J. Bayuga, and J. A. Beavo. “Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases.” J Biol Chem 273, no. 25 (June 19, 1998): 15553–58. https://doi.org/10.1074/jbc.273.25.15553.
    Full Text Link to Item
  - SODERLING, S. H. “Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase.” Proc Natl Acad Sci Usa 95 (1998): 8991–96.
  - Soderling, S. H., S. J. Bayuga, and J. A. Beavo. “Identification and characterization of a novel family of cyclic GMP phosphodiesterases.” Naunyn Schmiedebergs Archives of Pharmacology 358, no. 1 (January 1, 1998): R663–R663.
    Link to Item
  - Enslen, H., P. Sun, D. Brickey, S. H. Soderling, E. Klamo, and T. R. Soderling. “Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation.” J Biol Chem 269, no. 22 (June 3, 1994): 15520–27.
    Link to Item
- Book Sections
  - Uezu, Akiyoshi, and Scott Soderling. “Identifying Synaptic Proteins by In Vivo BioID from Mouse Brain.,” 2008:107–19, 2019. https://doi.org/10.1007/978-1-4939-9537-0_9.
    Full Text Link to Item
  - Soderling, S. H., and L. Van Aelst. “Principles driving the spatial organization of Rho GTPase signaling at synapses.” In Ras Superfamily Small G Proteins: Biology and Mechanisms 1: General Features, Signaling, 395–419, 2014. https://doi.org/10.1007/978-3-7091-1806-1_17.
    Full Text
- Conference Papers
  - Yan, Zhen, Eunjoon Kim, Dibyadeep Datta, David A. Lewis, and Scott H. Soderling. “Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?” In J Neurosci, 36:11411–17, 2016. https://doi.org/10.1523/JNEUROSCI.2360-16.2016.
    Full Text Link to Item
  - Chen, Yuxiao, Marija Milenkovic, Scott H. Soderling, and Amy J. Ramsey. “Restored WAVE1 Levels in a Model of NMDA Receptor Hypofunction Attenuates Working Memory Deficits.” In Biological Psychiatry, Vol. 77. ELSEVIER SCIENCE INC, 2015.
    Link to Item
Teaching & Mentoring
Recent Courses
- BIOLOGY 792: Research 2022
- CELLBIO 493: Research Independent Study 2022
- NEUROSCI 494: Research Independent Study 2 2022
- CELLBIO 493: Research Independent Study 2021
- NEUROBIO 393: Research Independent Study 2021
- NEUROBIO 793: Research in Neurobiology 2021
- NEUROSCI 493: Research Independent Study 1 2021
- CELLBIO 493: Research Independent Study 2020
- NEUROBIO 793: Research in Neurobiology 2020

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Previous Appointments & Affiliations

In the News

Subject Headings

Selected Grants

External Relationships

Selected Publications

Academic Articles

Book Sections

Conference Papers

Recent Courses