Scott Haydn Soderling | Scholars@Duke

Scott Haydn Soderling
Professor in Cell Biology

Current Appointments & Affiliations

Professor in Cell Biology, Cell Biology, Basic Science Departments 2017
Interim Chair, Department of Cell Biology, Cell Biology, Basic Science Departments 2018
Professor of Neurobiology, Neurobiology, Basic Science Departments 2017
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2005
Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2011

Contact Information

Duke Box 3709, Durham, NC 27710
Nanaline Duke Bldg, Durham, NC 27710
s.soderling@cellbio.duke.edu (919) 684-9001
Department of Cell Biology
Lab page

Background
Education, Training, & Certifications
- Postdoctoral Fellow, Hhmi, Oregon Health and Science University 1999 - 2005
- Ph.D., University of Washington 1999
Duke Appointment History
- Vice Chair of the Department of Cell Biology, Cell Biology, Basic Science Departments 2018
- Associate Professor in Cell Biology, Cell Biology, Basic Science Departments 2013 - 2017
- Associate Professor of Neurobiology, Neurobiology, Basic Science Departments 2013 - 2017
- Assistant Professor in Cell Biology, Cell Biology, Basic Science Departments 2005 - 2013
- Assistant Professor of Neurobiology, Neurobiology, Basic Science Departments 2007 - 2013
Recognition
In the News
- JUN 26, 2015
  
  Allen Song Named Interim Director of Brain Institute
- MAY 5, 2015 Los Angeles Times
  
  Schizophrenia's secrets begin to unravel
- MAY 1, 2015
  
  Scientists Reconcile Three Unrelated Theories of Schizophrenia
- JAN 6, 2015
  
  Study Pinpoints Autism-Linked Protein for Sculpting Brain Connections
Expertise
Subject Headings
Research
Selected Grants
- Epitranscriptomic Regulation of Synaptic Responses to Drugs of Abuse awarded by National Institutes of Health 2018 - 2023
- Analysis of Inhibitory Synaptic Proteins Associated with Brain Disorders awarded by National Institutes of Health 2017 - 2022
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Molecular Analysis of Developmental Brain Disorders Associated with Synaptic Pathology awarded by National Institutes of Health 2017 - 2022
- How Does Huntingtin Control Synaptic Development? awarded by National Institutes of Health 2018 - 2021
- New Proteomic and Genome Engineering Approaches to Decipher Astrocyte Function at Synapses awarded by National Institutes of Health 2018 - 2021
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Molecular, Synaptic, and Circuit Basis for Schizophrenia-related Phenotypes awarded by National Institutes of Health 2014 - 2020
- Thermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass Spectrometer awarded by National Institutes of Health 2018 - 2019
- Chemico-genetic analysis of serotonergic circuits and synapses awarded by Ruth K. Broad Biomedical Research Foundation 2018 - 2019
- Control of cell fate by progenitor mitosis length and microcephaly-linked genes during cortical development awarded by National Institutes of Health 2017 - 2019
- Unveiling Brain Circuits of Abnormal Social Behavior awarded by Brain and Behavior Research Foundation 2017 - 2019
- Basic predoctoral training in neuroscience awarded by National Institutes of Health 1992 - 2018
- Fragile X Phenotypes Modulated by Altered Signaling to the Synaptic Cytoskeleton awarded by National Institutes of Health 2014 - 2018
- Analysis of Arp2/3 activity as a major driver of dendritic spinogenesis awarded by National Institutes of Health 2015 - 2018
- Quantitative Analysis of the Postsynaptic Inhibitory Complex In Vivo awarded by National Institutes of Health 2015 - 2017
- Synaptic plasticity awarded by Max Planck Institute 2013 - 2016
- Training in Fundamental &Translational Neuroscience awarded by National Institutes of Health 2005 - 2016
- Fragile X Phenotypes Modulated by Altered Signaling to the Synaptic Cytoskeleton awarded by National Institutes of Health 2007 - 2014
- Agilent Direct Drive 9.4T MRS/MRI Console awarded by National Institutes of Health 2012 - 2013
- The effects of Nlrp12 and IL-1b in inflammatory disorders awarded by National Institutes of Health 2010 - 2012
- Mapping the Architecture of Cancer Signaling Pathways awarded by National Institutes of Health 2009 - 2012
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Spence, EF, Dube, S, Uezu, A, Locke, M, Soderblom, EJ, and Soderling, SH. "In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation." Nature Communications 10, no. 1 (January 23, 2019): 386-null. Full Text
  - Risher, WC, Kim, N, Koh, S, Choi, J-E, Mitev, P, Spence, EF, Pilaz, L-J, Wang, D, Feng, G, Silver, DL, Soderling, SH, Yin, HH, and Eroglu, C. "Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1." The Journal of Cell Biology 217, no. 10 (October 2018): 3747-3765. Full Text
  - Newpher, TM, Harris, S, Pringle, J, Hamilton, C, and Soderling, S. "Regulation of spine structural plasticity by Arc/Arg3.1." Seminars in Cell & Developmental Biology 77 (May 2018): 25-32. (Review) Full Text
  - Chen, Y, Milenkovic, M, Horsfall, W, Salahpour, A, Soderling, SH, and Ramsey, AJ. "Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown mice." Plos One 13, no. 10 (January 2018): e0199341-null. Full Text
  - Spence, EF, Kanak, DJ, Carlson, BR, and Soderling, SH. "The Arp2/3 Complex Is Essential for Distinct Stages of Spine Synapse Maturation, Including Synapse Unsilencing." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 36, no. 37 (September 2016): 9696-9709. Full Text
  - Uezu, A, Kanak, DJ, Bradshaw, TWA, Soderblom, EJ, Catavero, CM, Burette, AC, Weinberg, RJ, and Soderling, SH. "Identification of an elaborate complex mediating postsynaptic inhibition." Science (New York, N.Y.) 353, no. 6304 (September 2016): 1123-1129. Full Text
  - Rossi, MA, Li, HE, Lu, D, Kim, IH, Bartholomew, RA, Gaidis, E, Barter, JW, Kim, N, Cai, MT, Soderling, SH, and Yin, HH. "A GABAergic nigrotectal pathway for coordination of drinking behavior." Nature Neuroscience 19, no. 5 (May 2016): 742-748. Full Text
  - Singh, SK, Stogsdill, JA, Pulimood, NS, Dingsdale, H, Kim, YH, Pilaz, L-J, Kim, IH, Manhaes, AC, Rodrigues, WS, Pamukcu, A, Enustun, E, Ertuz, Z, Scheiffele, P, Soderling, SH, Silver, DL, Ji, R-R, Medina, AE, and Eroglu, C. "Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin." Cell 164, no. 1-2 (January 2016): 183-196. Full Text
  - Spence, EF, and Soderling, SH. "Actin out: Regulation of the synaptic cytoskeleton." Journal of Biological Chemistry 290, no. 48 (November 27, 2015): 28613-28622. (Review) Full Text
  - Spence, EF, and Soderling, SH. "Actin Out: Regulation of the Synaptic Cytoskeleton." The Journal of Biological Chemistry 290, no. 48 (November 2015): 28613-28622. (Review) Full Text
  - Zuchero, JB, Fu, M-M, Sloan, SA, Ibrahim, A, Olson, A, Zaremba, A, Dugas, JC, Wienbar, S, Caprariello, AV, Kantor, C, Leonoudakis, D, Lariosa-Willingham, K, Kronenberg, G, Gertz, K, Soderling, SH, Miller, RH, and Barres, BA. "CNS myelin wrapping is driven by actin disassembly." Developmental Cell 34, no. 2 (July 9, 2015): 152-167. Full Text
  - Kim, IH, Rossi, MA, Aryal, DK, Racz, B, Kim, N, Uezu, A, Wang, F, Wetsel, WC, Weinberg, RJ, Yin, H, and Soderling, SH. "Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine." Nature Neuroscience 18, no. 6 (June 2015): 883-891. Full Text
  - Zuchero, JB, Fu, MM, Sloan, SA, Ibrahim, A, Olson, A, Zaremba, A, Dugas, JC, Wienbar, S, Caprariello, AV, Kantor, C, Leonoudakis, D, Lariosa-Willingham, K, Kronenberg, G, Gertz, K, Soderling, SH, Miller, RH, and Barres, BA. "CNS Myelin Wrapping Is Driven by Actin Disassembly [Developmental Cell 34, 152-167; 27 July 2015]." Developmental Cell 34, no. 5 (January 1, 2015): 608-null. Full Text
  - Risher, WC, Patel, S, Kim, IH, Uezu, A, Bhagat, S, Wilton, DK, Pilaz, L-J, Singh Alvarado, J, Calhan, OY, Silver, DL, Stevens, B, Calakos, N, Soderling, SH, and Eroglu, C. "Astrocytes refine cortical connectivity at dendritic spines." Elife 3 (December 17, 2014). Full Text Open Access Copy
  - Kim, IH, Wang, H, Soderling, SH, and Yasuda, R. "Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall." ELIFE 3 (August 1, 2014). Full Text Link to Item
  - Kim, IH, Wang, H, Soderling, SH, and Yasuda, R. "Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall." Elife 3 (July 8, 2014). Full Text
  - Kim, IH, Wang, H, Soderling, SH, and Yasuda, R. "Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall." ELIFE 3 (July 8, 2014). Full Text Link to Item
  - Zhou, K, Muroyama, A, Underwood, J, Leylek, R, Ray, S, Soderling, SH, and Lechler, T. "Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation." Proc Natl Acad Sci U S A 110, no. 40 (October 1, 2013): E3820-E3829. Full Text Link to Item
  - Burianek, LE, and Soderling, SH. "Under lock and key: spatiotemporal regulation of WASP family proteins coordinates separate dynamic cellular processes." Seminars in Cell & Developmental Biology 24, no. 4 (April 2013): 258-266. (Review) Full Text
  - Kim, IH, Racz, B, Wang, H, Burianek, L, Weinberg, R, Yasuda, R, Wetsel, WC, and Soderling, SH. "Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 33, no. 14 (April 2013): 6081-6092. Full Text
  - Burianek, LE, and Soderling, SH. "Under lock and key: Spatiotemporal regulation of WASP family proteins coordinates separate dynamic cellular processes." Seminars in Cell and Developmental Biology 24, no. 4 (2013): 258-266. Full Text
  - Hazai, D, Szudoczki, R, Ding, J, Soderling, SH, Weinberg, RJ, Sótonyi, P, and Rácz, B. "Ultrastructural abnormalities in CA1 hippocampus caused by deletion of the actin regulator WAVE-1." Plos One 8, no. 9 (January 2013): e75248-null. Full Text
  - Kim, IH, Carlson, BR, Heindel, CC, Kim, H, and Soderling, SH. "Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus." The Journal of Biological Chemistry 287, no. 46 (November 2012): 39263-39274. Full Text
  - Uezu, A, Okada, H, Murakoshi, H, del Vescovo, CD, Yasuda, R, Diviani, D, and Soderling, SH. "Modified SH2 domain to phototrap and identify phosphotyrosine proteins from subcellular sites within cells." Proceedings of the National Academy of Sciences of the United States of America 109, no. 43 (October 2012): E2929-E2938. Full Text
  - Okada, H, Uezu, A, Soderblom, EJ, Moseley, MA, Gertler, FB, and Soderling, SH. "Peptide array X-linking (PAX): a new peptide-protein identification approach." PLoS One 7, no. 5 (2012): e37035-. Full Text Link to Item
  - Okada, H, Uezu, A, Mason, FM, Soderblom, EJ, Moseley, MA, and Soderling, SH. "SH3 domain-based phototrapping in living cells reveals Rho family GAP signaling complexes. (Published online)" Sci Signal 4, no. 201 (November 29, 2011): rs13-. Full Text Link to Item
  - Okada, H, Uezu, A, Mason, FM, Soderblom, EJ, Moseley, MA, and Soderling, SH. "SH3 domain-based phototrapping in living cells reveals rho family GAP signaling complexes." Science Signaling 4, no. 201 (November 29, 2011). Full Text
  - Mason, FM, Heimsath, EG, Higgs, HN, and Soderling, SH. "Bi-modal regulation of a formin by srGAP2." J Biol Chem 286, no. 8 (February 25, 2011): 6577-6586. Full Text Link to Item
  - Carlson, BR, Lloyd, KE, Kruszewski, A, Kim, I-H, Rodriguiz, RM, Heindel, C, Faytell, M, Dudek, SM, Wetsel, WC, and Soderling, SH. "WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 31, no. 7 (February 2011): 2447-2460. Full Text
  - Svitkina, T, Lin, W-H, Webb, DJ, Yasuda, R, Wayman, GA, Van Aelst, L, and Soderling, SH. "Regulation of the postsynaptic cytoskeleton: roles in development, plasticity, and disorders." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 30, no. 45 (November 2010): 14937-14942. (Review) Full Text
  - Mason, FM, and Soderling, SH. "WASP and WAVE Family Protein Complexes." (2010): 1265-1270. Full Text
  - Kim, IH, Park, SK, Hong, ST, Jo, YS, Kim, EJ, Park, EH, Han, SB, Shin, H-S, Sun, W, Kim, HT, Soderling, SH, and Kim, H. "Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for synaptic Rac signaling." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 29, no. 44 (November 2009): 14039-14049. Full Text
  - Carlson, B, and Soderling, SH. "Mechanisms of cellular protrusions branch out." Dev Cell 17, no. 3 (September 2009): 307-309. Full Text Link to Item
  - Soderling, SH. "Grab your partner with both hands: cytoskeletal remodeling by Arp2/3 signaling." Science Signaling 2, no. 55 (January 27, 2009): pe5-null. (Review) Full Text
  - Soderling, SH, Guire, ES, Kaech, S, White, J, Zhang, F, Schutz, K, Langeberg, LK, Banker, G, Raber, J, and Scott, JD. "A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory." J Neurosci 27, no. 2 (January 10, 2007): 355-365. Full Text Link to Item
  - Soderling, SH, and Scott, JD. "WAVE signalling: from biochemistry to biology." Biochem Soc Trans 34, no. Pt 1 (February 2006): 73-76. (Review) Full Text Link to Item
  - Vasta, V, Sonnenburg, WK, Yan, C, Soderling, SH, Shimizu-Albergine, M, and Beavo, JA. "Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm." Biol Reprod 73, no. 4 (October 2005): 598-609. Full Text Link to Item
  - Alto, NM, Soderling, SH, Hoshi, N, Langeberg, LK, Fayos, R, Jennings, PA, and Scott, JD. "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring." Proceedings of the National Academy of Sciences of the United States of America 100, no. 8 (April 2, 2003): 4445-4450. Full Text
  - Soderling, SH, Binns, KL, Wayman, GA, Davee, SM, Ong, SH, Pawson, T, and Scott, JD. "The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling." Nature Cell Biology 4, no. 12 (December 2002): 970-975. Full Text
  - Rascón, A, Soderling, SH, Schaefer, JB, and Beavo, JA. "Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei." Proceedings of the National Academy of Sciences of the United States of America 99, no. 7 (April 2002): 4714-4719. Full Text
  - Hetman, JM, Robas, N, Baxendale, R, Fidock, M, Phillips, SC, Soderling, SH, and Beavo, JA. "Cloning and characterization of two splice variants of human phosphodiesterase 11A." Proceedings of the National Academy of Sciences of the United States of America 97, no. 23 (November 2000): 12891-12895. Full Text
  - Westphal, RS, Soderling, SH, Alto, NM, Langeberg, LK, and Scott, JD. "Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold." The Embo Journal 19, no. 17 (September 2000): 4589-4600. Full Text
  - Soderling, SH, and Beavo, JA. "Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions." Current Opinion in Cell Biology 12, no. 2 (April 2000): 174-179. (Review) Full Text
  - Fawcett, L, Baxendale, R, Stacey, P, McGrouther, C, Harrow, I, Soderling, S, Hetman, J, Beavo, JA, and Phillips, SC. "Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A." Proceedings of the National Academy of Sciences of the United States of America 97, no. 7 (March 2000): 3702-3707. Full Text
  - Hetman, JM, Soderling, SH, Glavas, NA, and Beavo, JA. "Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase." Proceedings of the National Academy of Sciences of the United States of America 97, no. 1 (January 2000): 472-476. Full Text
  - SODERLING, SH. "Regulation of cAMP and cGMP signaling : new phosphodiesterases and new functions." Curr Opin Cell Biol 12 (2000): 174-179. Full Text
  - Soderling, SH, Bayuga, SJ, and Beavo, JA. "Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A." Proceedings of the National Academy of Sciences of the United States of America 96, no. 12 (June 1999): 7071-7076. Full Text
  - Juilfs, DM, Soderling, S, Burns, F, and Beavo, JA. "Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs)." Reviews of physiology, biochemistry and pharmacology 135 (1999): 67-104.
  - Soderling, SH, Bayuga, SJ, and Beavo, JA. "Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase." Proceedings of the National Academy of Sciences of the United States of America 95, no. 15 (July 1998): 8991-8996. Full Text
  - Soderling, SH, Bayuga, SJ, and Beavo, JA. "Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases." The Journal of Biological Chemistry 273, no. 25 (June 1998): 15553-15558. Full Text
  - SODERLING, S. "Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase." Proc Natl Acad Sci USA 95 (1998): 8991-8996.
  - Soderling, SH, Bayuga, SJ, and Beavo, JA. "Identification and characterization of a novel family of cyclic GMP phosphodiesterases." NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY 358, no. 1 (1998): R663-R663. Link to Item
  - Enslen, H, Sun, P, Brickey, D, Soderling, SH, Klamo, E, and Soderling, TR. "Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation." J Biol Chem 269, no. 22 (June 3, 1994): 15520-15527. Link to Item
  - Soderling, SH, Langeberg, LK, Soderling, JA, Davee, SM, Simerly, R, Raber, J, and Scott, JD. "Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice." Proceedings of the National Academy of Sciences of the United States of America 100, no. 4 (February 10, 2003): 1723-1728. Full Text
- Book Sections
  - Soderling, SH, and Van Aelst, L. "Principles driving the spatial organization of Rho GTPase signaling at synapses." In Ras Superfamily Small G Proteins: Biology and Mechanisms 1: General Features, Signaling, 395-419. May 1, 2014. Full Text
- Conference Papers
  - Yan, Z, Kim, E, Datta, D, Lewis, DA, and Soderling, SH. "Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?." November 2016. Full Text
  - Chen, Y, Milenkovic, M, Soderling, SH, and Ramsey, AJ. "Restored WAVE1 Levels in a Model of NMDA Receptor Hypofunction Attenuates Working Memory Deficits." May 1, 2015. Link to Item
Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Duke Appointment History

In the News

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers

Recent Courses