Dry powder vaccines for mucosal administration: critical factors in manufacture and delivery.

Journal Article (Journal Article;Review)

Dry powder vaccine formulations have proved effective for induction of systemic and mucosal immune responses. Here we review the use of dry vaccines for immunization in the respiratory tract. We discuss techniques for powder formulation, manufacture, characterization and delivery in addition to methods used for evaluation of stability and safety. We review the immunogenicity and protective efficacy of dry powder vaccines as compared to liquid vaccines delivered by mucosal or parenteral routes. Included is information on mucosal adjuvants and mucoadhesives that can be used to enhance nasal or pulmonary dry vaccines. Mucosal immunization with dry powder vaccines offers the potential to provide a needle-free and cold chain-independent vaccination strategy for the induction of protective immunity against either systemic or mucosal pathogens.

Full Text

Duke Authors

Cited Authors

  • Wang, SH; Thompson, AL; Hickey, AJ; Staats, HF

Published Date

  • 2012

Published In

Volume / Issue

  • 354 /

Start / End Page

  • 121 - 156

PubMed ID

  • 21822816

International Standard Serial Number (ISSN)

  • 0070-217X

Digital Object Identifier (DOI)

  • 10.1007/82_2011_167


  • eng

Conference Location

  • Germany