Prenatal dietary choline availability alters postnatal neurotoxic vulnerability in the adult rat.

Journal Article (Journal Article)

The availability of choline during the prenatal period influences neural and cognitive development. Here we report that choline supplementation during a six-day gestational period protects against neurodegeneration in the posterior cingulate and retrosplenial cortices of adult female rats produced by systemic administration of the N-methyl-D-aspartate receptor antagonist dizocilpine (MK-801). These data show that availability of choline during a brief prenatal period diminishes vulnerability to neurotoxicity in adult offspring.

Full Text

Duke Authors

Cited Authors

  • Guo-Ross, SX; Jones, KH; Shetty, AK; Wilson, WA; Swartzwelder, HS

Published Date

  • May 1, 2003

Published In

Volume / Issue

  • 341 / 2

Start / End Page

  • 161 - 163

PubMed ID

  • 12686390

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/s0304-3940(03)00119-8


  • eng

Conference Location

  • Ireland