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Prenatal dietary choline availability alters postnatal neurotoxic vulnerability in the adult rat.

Publication ,  Journal Article
Guo-Ross, SX; Jones, KH; Shetty, AK; Wilson, WA; Swartzwelder, HS
Published in: Neurosci Lett
May 1, 2003

The availability of choline during the prenatal period influences neural and cognitive development. Here we report that choline supplementation during a six-day gestational period protects against neurodegeneration in the posterior cingulate and retrosplenial cortices of adult female rats produced by systemic administration of the N-methyl-D-aspartate receptor antagonist dizocilpine (MK-801). These data show that availability of choline during a brief prenatal period diminishes vulnerability to neurotoxicity in adult offspring.

Duke Scholars

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

May 1, 2003

Volume

341

Issue

2

Start / End Page

161 / 163

Location

Ireland

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Nootropic Agents
  • Neurons
  • Gyrus Cinguli
  • Female
  • Excitatory Amino Acid Antagonists
  • Dizocilpine Maleate
 

Citation

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MLA
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Guo-Ross, S. X., Jones, K. H., Shetty, A. K., Wilson, W. A., & Swartzwelder, H. S. (2003). Prenatal dietary choline availability alters postnatal neurotoxic vulnerability in the adult rat. Neurosci Lett, 341(2), 161–163. https://doi.org/10.1016/s0304-3940(03)00119-8
Guo-Ross, Shirley X., Katherine H. Jones, Ashok K. Shetty, Wilkie A. Wilson, and H Scott Swartzwelder. “Prenatal dietary choline availability alters postnatal neurotoxic vulnerability in the adult rat.Neurosci Lett 341, no. 2 (May 1, 2003): 161–63. https://doi.org/10.1016/s0304-3940(03)00119-8.
Guo-Ross SX, Jones KH, Shetty AK, Wilson WA, Swartzwelder HS. Prenatal dietary choline availability alters postnatal neurotoxic vulnerability in the adult rat. Neurosci Lett. 2003 May 1;341(2):161–3.
Guo-Ross, Shirley X., et al. “Prenatal dietary choline availability alters postnatal neurotoxic vulnerability in the adult rat.Neurosci Lett, vol. 341, no. 2, May 2003, pp. 161–63. Pubmed, doi:10.1016/s0304-3940(03)00119-8.
Guo-Ross SX, Jones KH, Shetty AK, Wilson WA, Swartzwelder HS. Prenatal dietary choline availability alters postnatal neurotoxic vulnerability in the adult rat. Neurosci Lett. 2003 May 1;341(2):161–163.
Journal cover image

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

May 1, 2003

Volume

341

Issue

2

Start / End Page

161 / 163

Location

Ireland

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Nootropic Agents
  • Neurons
  • Gyrus Cinguli
  • Female
  • Excitatory Amino Acid Antagonists
  • Dizocilpine Maleate