Prenatal choline supplementation protects against postnatal neurotoxicity.

Journal Article (Journal Article)

Choline, a dietary compound present in many foods, has recently been classified as an essential nutrient for humans. There is evidence from animal models that the availability of choline during the prenatal period influences neural and cognitive development. Here we report that choline supplementation during a 6 d gestational period protects against neurodegeneration in the posterior cingulate and retrosplenial cortices of female adolescent rats produced by peripheral administration of the NMDA receptor antagonist dizocilpine (MK-801). These data show that availability of a single nutrient, choline, during a brief period of prenatal development diminishes vulnerability to neurotoxicity in adolescent offspring.

Full Text

Duke Authors

Cited Authors

  • Guo-Ross, SX; Clark, S; Montoya, DAC; Jones, KH; Obernier, J; Shetty, AK; White, AM; Blusztajn, JK; Wilson, WA; Swartzwelder, HS

Published Date

  • January 1, 2002

Published In

Volume / Issue

  • 22 / 1

Start / End Page

  • RC195 -

PubMed ID

  • 11756524

Pubmed Central ID

  • PMC6757618

Electronic International Standard Serial Number (EISSN)

  • 1529-2401


  • eng

Conference Location

  • United States