Prenatal choline supplementation protects against postnatal neurotoxicity.
Published
Journal Article
Choline, a dietary compound present in many foods, has recently been classified as an essential nutrient for humans. There is evidence from animal models that the availability of choline during the prenatal period influences neural and cognitive development. Here we report that choline supplementation during a 6 d gestational period protects against neurodegeneration in the posterior cingulate and retrosplenial cortices of female adolescent rats produced by peripheral administration of the NMDA receptor antagonist dizocilpine (MK-801). These data show that availability of a single nutrient, choline, during a brief period of prenatal development diminishes vulnerability to neurotoxicity in adolescent offspring.
Full Text
Duke Authors
Cited Authors
- Guo-Ross, SX; Clark, S; Montoya, DAC; Jones, KH; Obernier, J; Shetty, AK; White, AM; Blusztajn, JK; Wilson, WA; Swartzwelder, HS
Published Date
- January 1, 2002
Published In
Volume / Issue
- 22 / 1
Start / End Page
- RC195 -
PubMed ID
- 11756524
Pubmed Central ID
- 11756524
Electronic International Standard Serial Number (EISSN)
- 1529-2401
Language
- eng
Conference Location
- United States