Prenatal choline supplementation protects against postnatal neurotoxicity.
Publication
, Journal Article
Guo-Ross, SX; Clark, S; Montoya, DAC; Jones, KH; Obernier, J; Shetty, AK; White, AM; Blusztajn, JK; Wilson, WA; Swartzwelder, HS
Published in: J Neurosci
January 1, 2002
Choline, a dietary compound present in many foods, has recently been classified as an essential nutrient for humans. There is evidence from animal models that the availability of choline during the prenatal period influences neural and cognitive development. Here we report that choline supplementation during a 6 d gestational period protects against neurodegeneration in the posterior cingulate and retrosplenial cortices of female adolescent rats produced by peripheral administration of the NMDA receptor antagonist dizocilpine (MK-801). These data show that availability of a single nutrient, choline, during a brief period of prenatal development diminishes vulnerability to neurotoxicity in adolescent offspring.
Duke Scholars
Published In
J Neurosci
DOI
EISSN
1529-2401
Publication Date
January 1, 2002
Volume
22
Issue
1
Start / End Page
RC195
Location
United States
Related Subject Headings
- Sex Factors
- Receptors, N-Methyl-D-Aspartate
- Rats, Sprague-Dawley
- Rats
- Prenatal Exposure Delayed Effects
- Pregnancy
- Neuroprotective Agents
- Neurons
- Neurology & Neurosurgery
- Male
Citation
APA
Chicago
ICMJE
MLA
NLM
Guo-Ross, S. X., Clark, S., Montoya, D. A. C., Jones, K. H., Obernier, J., Shetty, A. K., … Swartzwelder, H. S. (2002). Prenatal choline supplementation protects against postnatal neurotoxicity. J Neurosci, 22(1), RC195. https://doi.org/10.1523/JNEUROSCI.22-01-j0005.2002
Guo-Ross, Shirley X., Suzanne Clark, Daniel A. C. Montoya, Katherine H. Jones, Jennifer Obernier, Ashok K. Shetty, Aaron M. White, Jan Krzysztof Blusztajn, Wilkie A. Wilson, and H Scott Swartzwelder. “Prenatal choline supplementation protects against postnatal neurotoxicity.” J Neurosci 22, no. 1 (January 1, 2002): RC195. https://doi.org/10.1523/JNEUROSCI.22-01-j0005.2002.
Guo-Ross SX, Clark S, Montoya DAC, Jones KH, Obernier J, Shetty AK, et al. Prenatal choline supplementation protects against postnatal neurotoxicity. J Neurosci. 2002 Jan 1;22(1):RC195.
Guo-Ross, Shirley X., et al. “Prenatal choline supplementation protects against postnatal neurotoxicity.” J Neurosci, vol. 22, no. 1, Jan. 2002, p. RC195. Pubmed, doi:10.1523/JNEUROSCI.22-01-j0005.2002.
Guo-Ross SX, Clark S, Montoya DAC, Jones KH, Obernier J, Shetty AK, White AM, Blusztajn JK, Wilson WA, Swartzwelder HS. Prenatal choline supplementation protects against postnatal neurotoxicity. J Neurosci. 2002 Jan 1;22(1):RC195.
Published In
J Neurosci
DOI
EISSN
1529-2401
Publication Date
January 1, 2002
Volume
22
Issue
1
Start / End Page
RC195
Location
United States
Related Subject Headings
- Sex Factors
- Receptors, N-Methyl-D-Aspartate
- Rats, Sprague-Dawley
- Rats
- Prenatal Exposure Delayed Effects
- Pregnancy
- Neuroprotective Agents
- Neurons
- Neurology & Neurosurgery
- Male