Prenatal exposure to ethanol decreases the sensitivity of the adult rat hippocampus to N-methyl-D-aspartate.

Journal Article (Journal Article)

Morphological, neurochemical, and electrophysiological studies suggest that the hippocampal formation is one of the brain regions most sensitive to the teratological consequences of prenatal exposure to ethanol. We now report that prenatal ethanol exposure results in a reduction in the sensitivity of the hippocampi of adult offspring to N-methyl-D-aspartate (NMDA). Moreover, it appears that reduced sensitivity to NMDA results from abnormal magnesium regulation of the NMDA receptor-channel complex. These deficits in hippocampal function may underlie some of the behavioral and learning deficits which are characteristic of the offspring of mothers that consume even moderate amounts of ethanol during pregnancy.

Full Text

Duke Authors

Cited Authors

  • Morrisett, RA; Martin, D; Wilson, WA; Savage, DD; Swartzwelder, HS

Published Date

  • September 1989

Published In

Volume / Issue

  • 6 / 5

Start / End Page

  • 415 - 420

PubMed ID

  • 2684213

International Standard Serial Number (ISSN)

  • 0741-8329

Digital Object Identifier (DOI)

  • 10.1016/0741-8329(89)90013-x


  • eng

Conference Location

  • United States